DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and mon2

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001033884.2	Gene:	mon2 / 326157	FlyBaseID:	FBgn0031985	Length:	1684	Species:	Drosophila melanogaster

Alignment Length:	854	Identity:	137/854 - (16%)
Similarity:	269/854 - (31%)	Gaps:	272/854 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 GSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLL--------------RTNGLCKTAEN- 625
            |..::.|...|...:::..:::.:.|.||.......:||              .|..:.|..:|
  Fly   489 GVIQRTPELHPSHNTAVITEEEHKPLCLQLVNSSWSALLSAFIPLVETSIDEATTENILKAMQNY 553

  Fly   626 ----GSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQ---QFSTHSADSAG 683
                |.|..:|.  .|:.:          :...|::.|..:......|::|   ....|:...:.
  Fly   554 AALCGMLEQLQP--RDAFI----------MAMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQ 606

  Fly   684 AVSGGGV-GVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQ 747
            .:|...: ..:|.||.:..|: .||.....:..:|    |::          .........:.||
  Fly   607 DLSSQFINSCSGDAGDFRPQI-VAVGTPLPSASLP----HSV----------MQAPVMLTNKNLQ 656

  Fly   748 AAAAAAGVAQN---------YKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVAR 803
            ...|...:|.|         :.:.:|::...:.:||     ||..|       |.|:..|:....
  Fly   657 CMRAILFLAHNNGGILGTSWHIVLQTLQHLVWILGL-----KPSTG-------GSLQAMPKPAVE 709

  Fly   804 FLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQV-DVALRK-FQAYFRMPGEAQKI 866
               ...|:...::.:          :.|||....:|..|.:.: ||||.. ..|..::..||.::
  Fly   710 ---ANVGIQTAVMAD----------LPVLSQMLSQLFESSQYLDDVALHHLIDALCKLSHEAMEL 761

  Fly   867 ERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGI 931
                 .::.|  |.:...|.:|..:..:.:....::......|...:...|.:|:.::     |:
  Fly   762 -----AYANR--EPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLEVCQHRHIRMREW-----GV 814

  Fly   932 DDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQV---MKVQATIVGKKPNLA------LPHRRLVC 987
            :....:.|..|          :||    |.|.:   |::|..::.....|:      :..|:|.|
  Fly   815 EAITYLVKSAL----------QFK----HKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDC 865

  Fly   988 YCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVT--LLDM 1050
            ..::.....            |:..|....:|..|.:..:.......|.:|.....|:|  |..|
  Fly   866 VLQILNTAG------------EILSFGWPAIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVM 918

  Fly  1051 P--NYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARN 1113
            |  ..|.||..:.|...:                .::|..|::.:..|.::   ::...|
  Fly   919 PWRCLPLCISTAAKFGSQ----------------TQELNISLTAIGLMWNI---SDFFNQ----- 959

  Fly  1114 RAPGNAENRD----SGVADVEVCP----------------CPYQQGSQASGEQAPNSADNSQQLK 1158
                   |:|    :.:.||.:.|                |.|.:..:...:..|....::.|..
  Fly   960 -------NQDKLMSTQLQDVSILPDFPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTL 1017

  Fly  1159 RSALS--NSLLD---------------------MHEQFGNEKPQRRGSV---------------- 1184
            .|.:|  .|||:                     :.....|||....|::
  Fly  1018 FSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDASGNILIHHSRNTAQKQWAET 1082

  Fly  1185 ----------------------GSLDSGMSISFQSTTTSSASRENAAAIAAAA--------NAAA 1219
                                  |..:...|:..:....::.|:....::||..        |.|.
  Fly  1083 QVLTLSGVCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNGEVSLAALKSLQEIMYHNTAE 1147

  Fly  1220 AAKMRFNMPPTA--------AIATPSNVYAAPGMQA-----YTHANFVQQSQAAYMLQQQQMLQQ 1271
            ..:.....|.||        .||.  |::.:.||::     .|.|...||:......|:...:..
  Fly  1148 RTERALKDPQTAQEQDEEIWTIAW--NIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPS 1210

  Fly  1272 QAQMQAQAQ 1280
            ||.:.|..|
  Fly  1211 QAFLTALIQ 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	31/189 (16%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	21/130 (16%)
mon2	NP_001033884.2	DCB	13..184	CDD:292830
		Sec7_N	213..380	CDD:289549
		DUF1981	827..909	CDD:286414	16/97 (16%)
		Mon2_C	912..1665	CDD:292823	54/341 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030