DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Arfgef1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001263985.1	Gene:	Arfgef1 / 312915	RGDID:	1560793	Length:	1846	Species:	Rattus norvegicus

Alignment Length:	703	Identity:	178/703 - (25%)
Similarity:	268/703 - (38%)	Gaps:	175/703 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 EEGASSSSAYGSATES-QLT----------------EQQQQQQAQQQQQPRVTIMAGPAGAASPG 431
            |.|:..|||....||: |.|                |::.|...|...:..|.|:.|..|..:.
  Rat   283 ENGSDISSAENEQTEADQATAAETLSKDDVLCDGECEEKPQDIVQSIVEEMVDIIVGDMGEGTA- 346

  Fly   432 LSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQ 496
                               .|......:||......|..|..:.:                   .
  Rat   347 -------------------VSASADGNAGAVEDGSDSENVQANGI-------------------P 373

  Fly   497 ALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPS 561
            ..|..|||..|.   |.|....||.||..:.   |:||.||...:....|     |.........
  Rat   374 GTPISAAYTPSL---PDDRLSVSSNDTQESG---NSSGPSPGAKFSHILQ-----KDAFLVFRSL 427

  Fly   562 CSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENG 626
            |..|....|.|         ||: ||.....:.....||||...|...|  :.|||.:...|...
  Rat   428 CKLSMKPLSDG---------PPD-PKSHELRSKILSLQLLLSILQNAGP--VFRTNEMFINAIKQ 480

  Fly   627 SLTSVQSSGSDSSV---------------TSAERNLNSD------------LGSDRSNSPHTW-- 662
            .|....|....|||               ::.:.:|...            |.:..|:..|.|
  Rat   481 YLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDHKWMV 545

  Fly   663 -------------------KRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQ-----M 703
                               .....||::..|.....|.:....|.|....|.:.|....     :
  Rat   546 IQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGL 610

  Fly   704 QAAVAAATAAGGMPPADDHAI--SSHTSAAQYEQHEQQ----QHEQ--------QQLQAAAAAAG 754
            :..|:.....  :..:.|..:  :|.|:..|.:..||:    :|.:        ..|::.:::..
  Rat   611 ECLVSILKCM--VEWSKDQYVNPNSQTTLGQEKPSEQEISEIKHPETINRYGSLNSLESTSSSGI 673

  Fly   755 VAQNYKMSETIRKRQYRV----------GLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRK 809
            .:.:.:||.|....|:.|          |::||||||::||.||..:|.|..||:.:|:||...:
  Rat   674 GSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEE 738

  Fly   810 GLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFS 874
            .|.....||:||: .::||..|:..:..:.|.||:....|||.|...||:|||||||:||||.|:
  Rat   739 RLDSTQAGEFLGD-NDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQKIDRLMEKFA 802

  Fly   875 QRYCECNADIVGR--LRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDI 937
            .||.|||.   |:  ..|:||.:|||::||||.||||:|.:|  .:|..|.:||..|||:|..|:
  Rat   803 ARYLECNQ---GQTLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDL 862

  Fly   938 DKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGK--KPNLALPHRRLVCY 988
            .::.|..||:.:...:       ::.....:.||..|  |.|:|...:|.:.|
  Rat   863 PEEYLSAIYNEIAGKK-------ISMKETKELTIPTKSTKQNVASEKQRRLLY 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	83/199 (42%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	2/8 (25%)
Arfgef1	NP_001263985.1	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224
		PLN03076	15..1763	CDD:215560	178/703 (25%)
		DCB	29..210	CDD:292830
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..248
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..410		21/87 (24%)
		Sec7_N	416..570	CDD:289549	30/170 (18%)
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	554..574		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..684		9/52 (17%)
		Sec7	695..879	CDD:279680	81/196 (41%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	708..712		3/3 (100%)
		DUF1981	1217..1297	CDD:286414
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740