DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Gbf1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006231558.1	Gene:	Gbf1 / 309451	RGDID:	1307160	Length:	1895	Species:	Rattus norvegicus

Alignment Length:	1111	Identity:	226/1111 - (20%)
Similarity:	385/1111 - (34%)	Gaps:	305/1111 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 VGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGGDVLKRTRAQSAYELSQDLLEKQIELLE-- 328
            |||.|.:.:...|||...:...:..:         .::|:::...:..::.|.|..:..:..|
  Rat   148 VGTHLTNESVCEIMQSCFRICFEMRL---------SELLRKSAEHTLVDMVQLLFTRLPQFKEEP 203

  Fly   329 RKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAY 393
            :.|.|...:..:..:.....        .|.....||..:|.|.::.....|.:...|.|.||.:
  Rat   204 KSYVGTNLKKISPCLLNTLE--------LSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKW 260

  Fly   394 GSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQ 458
                         ::|.:..:.||.|....| |:..|    ||...:||......:.....|.|.
  Rat   261 -------------KKQKRSPRPPRHTTKVMP-GSELP----TPNGAALSSNLTGGMPFIEAPTSI 307

  Fly   459 SGA---------SPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHD 514
            |.|         ||.:.|...:|:.|.:.....:|..|                      |||.:
  Rat   308 SSASSEAASTVVSPCTDSGLELSSQATSKEDLTDLEQA----------------------GSPRE 350

  Fly   515 LSYASSADTSLNAS-WVNTSGHSPHTPYYSAAQIYMRPK--GGSTTPTP-SCSGSTG-----SGS 570
            ::......|.:..| .::......|.....:|.:...|:  ...|:||. |.|.|..     :..
  Rat   351 ITTTEPGSTEIGVSDQLDPQQEGAHVEKAQSASVESIPEVLEECTSPTDHSDSASVHDMDYVNPR 415

  Fly   571 GGSGSGSSKK-----VPPEVP-----------------KRTSSITAQQQTQLLLLQRQTPPPPSL 613
            |...:.||:|     ||..:|                 :..|.:.......||.:..::.|....
  Rat   416 GVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQC 480

  Fly   614 LRTNGLCK----------------------------------------------------TAENG 626
            ....||.|                                                    |.||.
  Rat   481 QTLLGLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITVENP 545

  Fly   627 SL----------TSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALN----SSQQFSTH 677
            .:          ..||.....|.||  |..:|.|.....||......:..:.|    |.|.::||
  Rat   546 KMPYEMKEMALEAIVQLWRIPSFVT--ELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYTTH 608

  Fly   678 ---------SADSAGA------------------VSGGGVGVAGGAGVYAAQMQAAVAAATAAGG 715
                     ..||..|                  ...|...|.|....|.::..|:...||..
  Rat   609 LLSLDALLTVIDSTEAHCQAKVLNTLNQQEKKETARPGFEAVDGSPDTYKSERAASDGKATGV-- 671

  Fly   716 MPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQN---------------YKMSETI 765
              |:|  |...|.|:..:...|..:.....|: .|..:||.:.               .::.|..
  Rat   672 --PSD--APGLHFSSGGWLSTEHGKPGCSDLE-EAGDSGVDKKTTRKPPRFSCLLPDPRELIEIK 731

  Fly   766 RKRQYRV-GLNLFNKKPEKGITYLIRRGFL----ENTPQGVARFLITRKGLSRQMIGEYLGNLQN 825
            .|::..: |...||:||:|||.:|..:|.|    :||.  ||::|.....|.::||||::.:.:
  Rat   732 NKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTE--VAQWLRENPRLDKKMIGEFVSDRK- 793

  Fly   826 QFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRS 890
              ||.:|..|.......|.::|.|||.:...||:||||..|.||:|:|::.:..||.   ....:
  Rat   794 --NMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEHWRSCNG---SPFAN 853

  Fly   891 SDTIFVLAFAIIMLNTDLHTPNLKPERR-MRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEF 954
            ||..|.||:|:||||||.|..|::.:.. |.:|:|.|||:|::...|.::|:|..:|..:|::|.
  Rat   854 SDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEI 918

  Fly   955 KPGSDHVTQVMKVQATIVGKKPNL--ALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFN--- 1014
                     ||..:.|.:.::..:  .|.||..........:|       ||.:..::|...
  Rat   919 ---------VMPEEQTGLVRENYVWSVLLHRGATPEGIFLRVP-------PGSYDLDLFTMTWGP 967

  Fly  1015 DLLVITKIFSKK-----------------KTSVTYTFRNSF-----PLCG-TVVTLLDMPNYPFC 1056
            .:..::.:|.|.                 ..|..|...:.|     .||. |.::...:.|.|..
  Rat   968 TIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSV 1032

  Fly  1057 IQLSQKVDGKILITFNARNEHD---------------RCKFAEDLKESISEMDEMESLRIEAELE 1106
            ...:.|........|:..:.|.               :...|:.|.:::.|:::......:..|:
  Rat  1033 FGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQ 1097

  Fly  1107 RQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHE 1171
            |:::..||......:..|.:.         ..|.:.|..:.|::  .:|:.||.|     ||..:
  Rat  1098 REETPSNRGESTVLSFVSWLT---------LSGPEQSSVRGPST--ENQEAKRVA-----LDCIK 1146

  Fly  1172 QFGNEK 1177
            |...||
  Rat  1147 QCDPEK 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	70/193 (36%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	23/167 (14%)
Gbf1	XP_006231558.1	Sec7_N	434..579	CDD:289549	19/146 (13%)
Gbf1	XP_006231558.1	Sec7	733..918	CDD:279680	70/192 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740