DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Psd2

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006254639.1	Gene:	Psd2 / 307500	RGDID:	1311075	Length:	772	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	126/536 - (23%)
Similarity:	205/536 - (38%)	Gaps:	137/536 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 SSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTP--SCSGSTGSGSGGSGSGSSKKV 581
            ::|..|||:..:     ||.:......:..|.|.|......|  |.|.:.|...|..|:.....|
  Rat    34 TAASESLNSHVI-----SPVSEKTGTLEGTMEPVGNPDVALPGLSLSLTNGLALGQDGNILEDSV 93

  Fly   582 PPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGS----DSSVTS 642
            ... |.|.|....::.|           |.|      ||..||:..| .:...|.    |....:
  Rat    94 ESR-PWRASGPAEEEDT-----------PRS------LCLDAEDTQL-GLDCPGEPDVRDGFSAT 139

  Fly   643 AERNLNSDLGSDRSNSPHTWKRGTALNS--------------------------SQQFSTHSADS 681
            .|:.|.|:|           .|||..:|                          .||.:..|.:.
  Rat   140 FEKILESEL-----------LRGTQYSSLDSLDVLSLTDESDSCVSFEAPLTPLIQQRARDSPEP 193

  Fly   682 AGAVSG-----GGVGVAGGA-GVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQ--HEQ 738
            ||...|     |.:|.|||. |...:.::.:::::.:..         :.||.|......  ||.
  Rat   194 AGLGIGDIGPEGDLGAAGGGDGELGSPLRRSISSSRSEN---------VLSHLSLTSMPNGFHED 249

  Fly   739 Q--------QHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPE----KGITYLIRR 791
            :        :.::...:...:|:..:....:|::..:.....||...:..|.    :|::...||
  Rat   250 EPGGSGGDDEDDEDTDKVLNSASDTSLKDGLSDSDSELSSSEGLEPGSTDPMANGCQGVSEAARR 314

  Fly   792 GFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAY 856
                     :||.|...:|..|..:...||. .|:|:..|...:....|.||..:|.|||.|...
  Rat   315 ---------LARRLYHLEGFQRCDVARQLGK-NNEFSRLVAGEYLSFFDFSGLTLDRALRTFLKA 369

  Fly   857 FRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRV 921
            |.:.||.|:.||::..||:|||:||.|   ...|.|.|..|..|:::|||||| .::...::|..
  Rat   370 FPLMGETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLH-GHVNIGKKMSC 430

  Fly   922 EDFIKNLRGIDDCHDIDKDMLMGIYDRVKS---------------------DEFKPGSDHVTQVM 965
            :.||.||..::|..|..||:|..:|:.:|:                     |:|..|:..||:::
  Rat   431 QQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRIL 495

  Fly   966 KVQATIVGKKPNLALP 981
            .      |..|.|.:|
  Rat   496 D------GGNPFLDVP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	62/212 (29%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	1/1 (100%)
Psd2	XP_006254639.1	Sec7	295..463	CDD:238100	59/181 (33%)
Psd2	XP_006254639.1	PH_EFA6	509..632	CDD:270107
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830