Protein Alignment siz and Arfgef2

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_851597.2
• Gene: Arfgef2 / 296380
• RGDID: 631430
• Length: 1791
• Species: Rattus norvegicus
• Alignment Length: 788
• Identity: 180/788 - (22%)
• Similarity: 291/788 - (36%)
• Gaps: 227/788 - (28%)

  Fly   342 TIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQ 406
            |::..:..|:..|...:.|. |||.......::.|                   ..|:|:.::.:
  Rat   162 TVRTCYNIYLASKNLINQTT-AKATLTQMLNVIFT-------------------RMENQVLQEAR 206

  Fly   407 QQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLS---MRERRQLDCSPIPRSQSG-------- 460
            :.:...|.:|:..::...||  ||..||...:::.|   ..|:.:|......||..|
  Rat   207 ELEKPIQSKPQSPVIQATAG--SPKFSRLKQSQAQSKPTTPEKTELPNGDHARSSLGKVNSENGE 269

  Fly   461 ------------ASPASISSS-----------TVSTSALASHPHVNLLHAAE----PHYYNAQAL 498
                        |.|:..|.:           .|.|||:.        .|||    |....|..:
  Rat   270 AHRERGSSISGRAEPSGGSDNGAQEVVKDILEDVVTSAVK--------EAAEKQGLPEPDQAPGV 326

  Fly   499 PQ--------GAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGH------------SPHTPYYS 543
            |:        .....:..:|...|....|||| :|..   :..||            .....:.|
  Rat   327 PECQECTVPPAVDENSQTNGIADDRQSLSSAD-NLEP---DAQGHPVAARFSHILQKDAFLVFRS 387

  Fly   544 AAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTP 608
            ..::.|:|.|                          :.||: ||.....:.....||||...|..
  Rat   388 LCKLSMKPLG--------------------------EGPPD-PKSHELRSKVVSLQLLLSVLQNA 425

  Fly   609 PPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSA----------------------------ER 645
            .|  :.|::.:..||....|....|....|||...                            |.
  Rat   426 GP--VFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEI 488

  Fly   646 NLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQM------Q 704
            .||. |.:..|:..|.|.      ..|..:...||:...|.   :.|.....:.||.:      .
  Rat   489 FLNI-LETSTSSFEHRWM------VIQTLTRICADAQCVVD---IYVNYDCDLNAANIFERLVND 543

  Fly   705 AAVAAATAAG---GMPPADDHAI--------------------------SSHTSAAQYEQHEQQQ 740
            .:..|...:|   ||.|..:.::                          :...:..|....:|:.
  Rat   544 LSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEM 608

  Fly   741 HEQQQLQAA--------------AAAAGVAQNYKMSETIRKRQYRV--GLNLFNKKPEKGITYLI 789
            .:.:.|..|              .....:..:.:..|.|::::..:  |:.||||||::||.:|.
  Rat   609 GDGKGLDMARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQ 673

  Fly   790 RRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQ 854
            .:|.|....:.:|:||...:.|....:||:||: ..:||..|:..:..:||...::...|||.|.
  Rat   674 EQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGD-STRFNKEVMYAYVDQLDFCEKEFVSALRTFL 737

  Fly   855 AYFRMPGEAQKIERLMEIFSQRYCECNADIVGR--LRSSDTIFVLAFAIIMLNTDLHTPNLKPER 917
            ..||:|||||||:||||.|:.||.|||.   |:  ..|:||.:|||::||||.||||:|.:|  .
  Rat   738 EGFRLPGEAQKIDRLMEKFAARYIECNQ---GQTLFASADTAYVLAYSIIMLTTDLHSPQVK--N 797

  Fly   918 RMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRV--KSDEFKPGSDHVTQVMKVQATIVGKKPNLAL 980
            :|..|.:||..|||:|..|:.::.|..||:.:  |....|...:|   .|..::|    |.|:|.
  Rat   798 KMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEH---TMATKST----KQNVAS 855

  Fly   981 PHRRLVCY 988
            ..:|.:.|
  Rat   856 EKQRRLLY 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	78/193 (40%)
		PH_IQSEC	981..1108	CDD:270128	2/8 (25%)
Arfgef2	NP_851597.2	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224		12/81 (15%)
		PLN03076	11..1718	CDD:215560	180/788 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..292		17/85 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..350		7/38 (18%)
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	515..535		5/22 (23%)