DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment siz and CYTH4

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_037517.1	Gene:	CYTH4 / 27128	HGNCID:	9505	Length:	394	Species:	Homo sapiens

Alignment Length:	414	Identity:	118/414 - (28%)
Similarity:	192/414 - (46%)	Gaps:	83/414 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 HAISSHTSAAQYEQHEQQQHEQQQL---------QAAAAAAGV-----AQNYKMSETIRKRQYRV 772
            |...:..|:.:.|:.::.:..::||         :.|...|.:     |:..:|::  ::::..:
Human     5 HPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ--KEKELCI 67

  Fly   773 GLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAM 837
            |...||..|.|||.|.|....|....|.:||||...:||::..||.|||. ::..|:.||..|..
Human    68 GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGE-RDPINLQVLQAFVD 131

  Fly   838 ELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAII 902
            ..:.:...:..|||:|...||:|||||||:|:||.|:.|||.||.   |..:|:||.:||:|:||
Human   132 CHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNP---GVFQSTDTCYVLSFSII 193

  Fly   903 MLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFK----PGSDHVTQ 963
            ||||.||.||::.  |...|.|:...|||::..|:.:|.|..::|.:||:.|.    .|:|
Human   194 MLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGND---- 252

  Fly   964 VMKVQATIVGKKPNLALPHRRLVCYCRLYEIPD-----VNKKERPGVHQREVFLFNDLLVITKIF 1023
                            |.|        .:..||     :....|....:|..|:..|..:....|
Human   253 ----------------LTH--------TFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEF 293

  Fly  1024 SKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQL------SQKV-------DGKIL------I 1069
            :..|..     |...||....|..:|.|..|||::|      .||:       ||:::      .
Human   294 TTDKEP-----RGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESY 353

  Fly  1070 TFNARNEHDRCKFAEDLKESISEM 1093
            ..:|.:..:|.::.|.::.||:.:
Human   354 RISATSAEERDQWIESIRASITRV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	77/187 (41%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	28/137 (20%)
CYTH4	NP_037517.1	Sec7	61..243	CDD:279680	77/187 (41%)
		PH_GRP1-like	258..376	CDD:269954	27/122 (22%)
		PH	262..374	CDD:278594	23/116 (20%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275		1/6 (17%)
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740