Protein Alignment siz and sec74

DIOPT Version :9

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_594894.2
• Gene: sec74 / 2542073
• PomBaseID: SPAC26F1.01
• Length: 928
• Species: Schizosaccharomyces pombe
• Alignment Length: 968
• Identity: 189/968 - (19%)
• Similarity: 330/968 - (34%)
• Gaps: 316/968 - (32%)

  Fly   453 PIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSY 517
            |:|..:.|.|        ...|||...   |....::|........|:    .:|.| ||...:|
pombe    28 PLPSRRKGKS--------ALRSALEKK---NRKSKSKPKVTITSDTPK----VSSQH-SPVSSAY 76

  Fly   518 ASSADTSLNASWVNTSGHSPH---TPYYSAAQIYMRPK--GGSTTPTPSCSGS--TGSGSGGSGS 575
            ...:.|.|::.    ||||..   :...|:|.....||  ..|.:.:..||..  ..|.|.|.|.
pombe    77 TGDSTTDLDSK----SGHSSSQKLSNKVSSALKLTIPKRWRSSKSSSSQCSSPFLPTSSSNGHGD 137

  Fly   576 GSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLT-SVQSSGSDSS 639
            .:|..:|.:..:.:|..:........:......|..|.|........||..:.| |:..|||.:.
pombe   138 DASLNLPDKKSRPSSQSSIFLSNWSTIFSSNASPTDSQLSPTHTSTIAELAASTLSIFPSGSYAG 202

  Fly   640 VT---SAERNLNSDLGSDRSNSPHTWKRGTALNS-SQQFSTHSADSAGAVSGGGVGVAGGAGVYA 700
            .|   .:..:::|.....||.|         :|| |..||..:                     .
pombe   203 STFGSPSRSSIDSSTYLPRSKS---------VNSLSSNFSART---------------------P 237

  Fly   701 AQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETI 765
            |..|::|:...   |..|..||..:|.| .:.:...:..||:                  ..|||
pombe   238 ASNQSSVSEDF---GAAPNCDHKHNSVT-LSDFALPDIDQHD------------------TVETI 280

  Fly   766 RKRQYRVGLNLFNKKPEKGITYLIRRGFLENTP----QGVARFLITRKGLSRQMIGEYLGNLQNQ 826
            .::                :.:.|.:.|   ||    ||.:..|       :..:.:||
pombe   281 LEK----------------VEFTIPKQF---TPAILSQGTSSLL-------KLCLRKYL------ 313

  Fly   827 FNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSS 891
             ::....|.::         |:|||||.|.:.:|.|.|:|:|::..||.:|..||.|:..   ||
pombe   314 -SVVNFKCISL---------DMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYD---SS 365

  Fly   892 DTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRV------- 949
            |..::|.|::::|:||..  |:...::|...:||.|    .:...|..::|...||.:
pombe   366 DECYILTFSLMILHTDFF--NIHNRQKMTRAEFISN----TNLPTILPEILECFYDNITYTPFVH 424

  Fly   950 ------------------------------KSDEFKPGSDHVTQVMKVQATIVGKKPNL------ 978
                                          |.:.|...|||  |.::.|.|  |.:.||
pombe   425 VEHIGCVVTSPSNEKPSLSQRLGDSQFRLTKRNTFATESDH--QALQEQLT--GFRINLDSILDL 485

  Fly   979 -------------------------ALPHRRLV-------CYCRLYEIPDVNKKERPGVHQREVF 1011
                                     ..|..::|       .:...:|....::...|.:...:||
pombe   486 KKIDSVRTSIESPTRTADDLYKEFARAPFLQIVSHRSQPQAFSYHFEPSAESESTNPAIINVKVF 550

  Fly  1012 -----LFNDLLVITKIFSKKKTSVTYT------FRNSFPLCGTVVTLLDM-------PNY----- 1053
                 :.|:.:...::.|.::..|..|      |:|.:.:.|.:..|.|.       |.|
pombe   551 KLGILIQNEKVRKDRLLSNREVGVILTSSQLMFFKNVYWISGLLDQLEDFKRSHSFSPCYFSPHL 615

  Fly  1054 -----PFCIQLSQKV---DG----KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELE 1106
                 .:.|.||..|   ||    ..|.:|:.:.::.|....     |::.:||:....::....
pombe   616 TSLSADYIIPLSDLVAYGDGSRIENELYSFSVKQKNQRTHVF-----SVTNVDELNDWLVKINFV 675

  Fly  1107 RQKSARNRAPGN----AENRDSGV-ADVEVCPCPYQQG---SQASGEQAPNSADNSQQLKRSALS 1163
            ...:....||..    .|:.|..: |.|.|.|..|:..   |:||.|......:.| :::...:.
pombe   676 STFATAGLAPRERLPCVESSDKSIKASVSVLPDIYEDSDAMSKASKETRSEVLECS-KVRVYIVQ 739

  Fly  1164 NSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAIAAAANAAAAAKMRFNMP 1228
            |.:..:.|..      |:|     :|.|::          .|.|||.|.......:..::|
pombe   740 NRIYKLEEAL------RQG-----ESKMTV----------QRRNAANILHLEPIQSRTRIR---- 779

  Fly  1229 PTAAIATPSNVYAAPGMQAYTHANFVQQSQAAYMLQQQ------QMLQQQAQMQAQAQ 1280
                :|..||.              ::::..|.|::.|      :.|::..:|.:..|
pombe   780 ----LARCSNT--------------LKKNMLAQMIEIQKFKISIKFLKEDLEMDSHLQ 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	46/228 (20%)
		PH_IQSEC	981..1108	CDD:270128	29/168 (17%)
sec74	NP_594894.2	Sec7	<308..422	CDD:279680	38/138 (28%)
		PH	549..676	CDD:278594	25/131 (19%)
		PH	549..676	CDD:214574	25/131 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000