DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment siz and SPAC11E3.11c

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_594936.1	Gene:	SPAC11E3.11c / 2541783	PomBaseID:	SPAC11E3.11c	Length:	942	Species:	Schizosaccharomyces pombe

Alignment Length:	817	Identity:	157/817 - (19%)
Similarity:	264/817 - (32%)	Gaps:	273/817 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 SQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSA 521
            |....||:|:|..: .||..:|.|.:..|..              :.::.:...|.|.|
pombe    18 SNDKRSPSSLSQRS-KTSTRSSKPFLQRLFP--------------STWFKNESSSRHPL------ 61

  Fly   522 DTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGG---STTPTPS---------CSGSTGSGSGGSG 574
             ||:..:...|.|..|.    ...:::.:.|..   ||...||         .|.||...:|.|.
pombe    62 -TSIKENDTQTIGRRPS----MRVKLFGKDKSKASMSTNDLPSHPRSQSVMGFSSSTSQLTGTSN 121

  Fly   575 SG---------------------SSKKVPPEVPKRTS-------------SITAQQ-------QT 598
            |.                     ||...|.::|.|.|             |.:|:.       .|
pombe   122 SSRTRLNKDMRRDFGMTSMSSITSSTPTPSQLPVRPSTSLSFFDDIPLGPSFSAETILSSLSIST 186

  Fly   599 QLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAE-----RNLNSDL------G 652
            ....:.:.||.|| |:.|..:             |:..|...|..|     ..|||.:      .
pombe   187 SNNAMSKTTPAPP-LVTTKSI-------------SADQDDFYTCKEEVSTYEGLNSQIELSPVKS 237

  Fly   653 SDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMP 717
            .|..|.       :|.|.|..:.|.|.:|...:....|...|.:                   ..
pombe   238 RDSQNK-------SAKNLSTAYRTVSGESRNLMVDPKVSPYGNS-------------------RT 276

  Fly   718 PADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKR---------QYRVG 773
            |..|        ::.|.:..:..:.|..|....:.         |||.||.         |.||.
pombe   277 PLRD--------SSNYLRDRRSINRQSSLSIPKST---------SETTRKTLALSNGGIDQSRVS 324

  Fly   774 LNLFNKKPEKGITYLIRRGFLENTPQGVAR-----FLITRKGLSRQMIGEYLGNLQNQFNMAVLS 833
            .:.|  |.:.....:......|.:...|:.     :|:|.|                .:|.|||.
pombe   325 SDSF--KVDDSSAKMAAIDIWEGSQHIVSNDKALSWLVTDK----------------PYNKAVLK 371

  Fly   834 CFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLA 898
            .:....|.....:..:||.......:.||.|:::..:..||.::|..|..  |...:...:..:|
pombe   372 HYISLYDFENTDILQSLRMICGNLYVHGETQELDHFLGEFSNQWCRTNPK--GLFCNPQIVHSIA 434

  Fly   899 FAIIMLNTDLHTPNLKPERRMRVEDFIKNL-----RGIDDCHDIDKD----MLMGIYDRVKSDEF 954
            |::::||||||...|....||....|::|.     :.::|..|.:::    ..:..|....|:|
pombe   435 FSLLLLNTDLHIAELSASERMSRNQFVENTYRSIKQALNDSFDGNEEKKNAFFLSSYKSFASNE- 498

  Fly   955 KPGSDHVTQVMKVQATI-VGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLV 1018
               |.:...:..:...: .||...|...|:|           .::.|                 |
pombe   499 ---SCNSPAIHSLHGNLSPGKSAELKKLHKR-----------SLSSK-----------------V 532

  Fly  1019 ITKIFSKKKTSVTYTFRNSFPLCGTVV--TLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCK 1081
            :.:.||....|......:|..:...:.  ..||| |:.|  ..:.|::.........|:.|
pombe   533 LEEAFSSYWMSALKEMYHSIKVSMILQPDRYLDM-NFDF--NDTNKINNPSSTANQTRHFH---- 590

  Fly  1082 FAEDLKESISEMDE--MESLRIEAELERQKSAR--NRAPGNAENRDSGVADVEVCPCPYQQGSQA 1142
                   |:||:.:  |.:..:|..:.|..:|.  ||...||.:.|.. .|:        ||:.
pombe   591 -------SVSEIKKLPMGTDELEKSMVRPSTAMYINRQNENAVSIDKS-RDL--------QGTV- 638

  Fly  1143 SGEQAPNSADNSQQLK-RSALSNSLLDMHEQFGNEKP 1178
                      |::::: |||||         :.|::|
pombe   639 ----------NTKEIRSRSALS---------YQNDRP 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	44/210 (21%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	21/130 (16%)
SPAC11E3.11c	NP_594936.1	COG5307	1..942	CDD:227623	157/817 (19%)
		Sec7	296..499	CDD:214569	49/235 (21%)
		PH_9	679..804	CDD:292052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000