Protein Alignment siz and Iqsec2

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_006528905.1
• Gene: Iqsec2 / 245666
• MGIID: 3528396
• Length: 1520
• Species: Mus musculus
• Alignment Length: 1555
• Identity: 461/1555 - (29%)
• Similarity: 643/1555 - (41%)
• Gaps: 451/1555 - (29%)

  Fly    38 GNQGGPGGSAGGVAPPGPVSLPLPLSINMPHHHVHAMPYNVDELLRENNALHA----------KI 92
            |..||||..:...|                          |:.||..||.:.:          :|
Mouse     6 GPPGGPGSESPNRA--------------------------VEYLLELNNIIESQQQLLETQRRRI 44

  Fly    93 KELSLERDRLLCEVSNLRLE--LDMSELKRLPVDLDDNFPQKS-LERSGSTQY---ELAGAQQPG 151
            :||..:.|:|..|..:||.|  |...||.|.|:...|:..::| .:....||:   ||..:|
Mouse    45 EELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQ--- 106

  Fly   152 SANASTCTDSGSVGGYVYLQNHYAPGAHSSSAAINYP----AQQHPQMVYQIQQYPTCHQQQQ-- 210
                                      .|.:|..:.||    |.|:.:.:|:.::....:|.|.
Mouse   107 --------------------------FHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTT 145

  Fly   211 ----QQHLQQQQHLH-------------QTGAGH--------YMQVTATGGGQYHHHHMLH---- 246
                ::....|.|||             :.|..|        |......|.........|.
Mouse   146 GYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGAS 210

  Fly   247 -------GHGH-----------------------------HAHHH---------------GGAVV 260
                   |.||                             |..|.               .|.
Mouse   211 RSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGR-- 273

  Fly   261 IAGSGV-GTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGG----------------------- 301
            :|.|.| |...||..::.:.....|...:.:.....|...||
Mouse   274 LAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWAQRARLQPASVALR 338

  Fly   302 ----DVLKRTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASIT 360
                :.:||::|.| :||||.||.:|::|:||||||| ..:|.||.|||.|||.|.|.|.|..:.
Mouse   339 KQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLR 403

  Fly   361 AMAKAEKRLSRRMVVT--ASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAG 423
            :.| :|.|:|||::::  .......|...:.:.||.....:.|.|                  ..
Mouse   404 SSA-SESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDE------------------GA 449

  Fly   424 PAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASI--SSSTVSTSALASHPHVNLLH 486
            .|||.|..|.|..|                    ..|:....|  ..|:|:||...|:....|
Mouse   450 MAGARSHRLERGLP--------------------YGGSCGGGIDGGGSSVTTSGEFSNDITEL-- 492

  Fly   487 AAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRP 551
              |..:                  |....|.|.|.|.:||.   :.||.....|  .:||:..|.
Mouse   493 --EDSF------------------SKQVKSLAESIDEALNC---HPSGPMSEEP--GSAQLEKRE 532

  Fly   552 KGGSTTPTPSCSGSTGSGSGGSGSGSS-------KKVPPEVPKRTSSITAQQQTQLLL-----LQ 604
                         |.......|.:..|       ..|||..|:|..|.....|.:...     |.
Mouse   533 -------------SKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLP 584

  Fly   605 RQTPPPPSLLRTNGLCKTAENGS--------------------LTSVQSSGSDSSVTSAERNLNS 649
            ...||.|...|.:|   :.|.|:                    |.:::.. |||||..::|   |
Mouse   585 PVPPPMPPGTREDG---SREEGTRRGPGCLECRDFRLRAAHLPLLTIEPP-SDSSVDLSDR---S 642

  Fly   650 DLGSDRSN--------SPH-TWKR----GTALNSSQQFSTHS------------ADSAGAVSGGG 689
            |.||....        ||| |.|.    |.|....:.:....            |.::|.   |.
Mouse   643 DRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGT---GP 704

  Fly   690 VGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAG 754
            .|||||..:...:    .|...:.||    |:.::.|.:::.:..........:..|:...|...
Mouse   705 SGVAGGRRLGKCE----AAGENSDGG----DNESLESSSNSNETINCSSGSSSRDSLREPPATGL 761

  Fly   755 VAQNYKM------------SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLIT 807
            ..|.|:.            ::.:::|.||:|||||||||||||.|||.||||.:||.|||.|::.
Mouse   762 CKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILE 826

  Fly   808 RKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEI 872
            |||||||||||:|||.|.|||..||.|...|:|.|...:|.||||||::.|:.|||||:|||:|.
Mouse   827 RKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 891

  Fly   873 FSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDI 937
            ||||||.||..:|.:.|:.||||:||||||:||||:::|::|.||:|:::||||||||:|:..||
Mouse   892 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDI 956

  Fly   938 DKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKER 1002
            .:|:|:|||.|::..|.:...|||:||..|:..||||||.|:||||||||.|:|||:||.|:.:|
Mouse   957 PRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQR 1021

  Fly  1003 PGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDG-- 1065
            .|:|||||||||||||:||||.|||..|||:||.||||....:.|.....|.|.|:|...|.|
Mouse  1022 LGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGE 1086

  Fly  1066 -KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKS-ARNRA--PGNAENRDSGV 1126
             |:||.|||.:..||.:|..||:|||:|:.|||..|:|:|||:||. .|..|  ||.|::..:|.
Mouse  1087 RKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGT 1151

  Fly  1127 ADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGM 1191
            .            :::|.|....:.|.   |||.|||:||.|:.:.   .|..||.|||||||.:
Mouse  1152 L------------ARSSLEDTYGAGDG---LKRGALSSSLRDLSDA---GKRGRRNSVGSLDSTI 1198

  Fly  1192 SISFQSTT------------------TSSASRENAAAIAAAANAAAAAKMRFNMPP------TAA 1232
            ..|..|:.                  .|.....|:::...:...:...|..|.|||      :|:
Mouse  1199 EGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASAS 1263

  Fly  1233 IATPSNVY----------------AAPGMQA---YTHANFVQQSQAA---YMLQQQQMLQQQAQM 1275
            .::.|:.:                ..|..|:   ..||.:.|....|   |:..||..|....|
Mouse  1264 SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQ- 1327

  Fly  1276 QAQAQAQAQAQAQAQAQAQAQAQAQPL--------TGRIP-------GRERKASRTDENG 1320
                  |.....|..:.....|.|.|:        .|.:|       ||..:|.|....|
Mouse  1328 ------QPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGG 1381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	116/187 (62%)
		PH_IQSEC	981..1108	CDD:270128	75/129 (58%)
Iqsec2	XP_006528905.1	GAS	26..>146	CDD:464001	32/148 (22%)
		Sec7	785..973	CDD:460178	116/187 (62%)
		IQ_SEC7_PH	995..1124	CDD:465120	74/128 (58%)
		KLF1_2_4_N	<1350..1457	CDD:425360	7/32 (22%)