DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Iqsec3

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001028526.1	Gene:	Iqsec3 / 243621	MGIID:	2677208	Length:	1195	Species:	Mus musculus

Alignment Length:	1271	Identity:	388/1271 - (30%)
Similarity:	542/1271 - (42%)	Gaps:	313/1271 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 VHAMPYNVDELLRENNALHAKIKELSLERDRLLCEVSNLRLELDMSELKRLPVDLDDNFPQKSLE 135
            :|.....:|||.|       ::.|||.| :|.|.|...| |:      .:.|..|....|...|.
Mouse    29 IHTQRQRIDELER-------RLDELSAE-NRSLWEHQQL-LQ------AQPPPGLVPPPPSAPLP 78

  Fly   136 RSGSTQYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYAPGAHSSSAAINYPAQQHPQMVYQIQ 200
            ....|....|.||:|                   ||:|    .....|:...|.|.|.|::.|.|
Mouse    79 APAVTAPAAAAAQEP-------------------LQDH----GQLIPASPEPPLQHHGQLLAQPQ 120

  Fly   201 QYPTCHQQQQQQHLQQQQHLHQTGAG---------------------HYMQVTATGGG----QYH 240
            ..|:...|     ..|..|.|....|                     .:....|.|.|    :..
Mouse   121 PAPSSRVQ-----TPQSPHQHPVAPGAIADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPE 180

  Fly   241 HHHMLH-------------GHGHHAHHHGGAVVIAGSG----VGTGLGSGATSVIMQHQQQQQQQ 288
            :..:||             .....|....|:...||.|    |...:.:|..|......|..:.|
Mouse   181 NETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQ 245

  Fly   289 QNMHKKNSI---RNG---------------GDVLKRTRAQSAYELSQDLLEKQIELLERKYGG-V 334
            |...:..::   |.|               ..:...|.|.|.||||.||..||||:||.|||| :
Mouse   246 QEEERPGAVGSPRAGPLRAASPGRQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHL 310

  Fly   335 RARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVV------TASSLGLAE----EGASS 389
            .:|.||.|||.|||.|.:.|.|..| ..:..|.||.||:.:      ||.|| :||    ||..
Mouse   311 VSRRAACTIQTAFRQYQLSKNFEKI-RNSLLESRLPRRISLRKVRAPTAESL-VAEKALLEGCG- 372

  Fly   390 SSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPI 454
                                          ::..|.| .||.|   |||.:.|:.|   |:.|..
Mouse   373 ------------------------------LLGLPLG-RSPSL---PPTFAGSLTE---LEDSFT 400

  Fly   455 PRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYAS 519
            .:.||.|.....:.||.|...:.|                   |.:..||  ..|.:.|.
Mouse   401 EQVQSLAKSIDDALSTWSLKTMCS-------------------LQESGAY--QLHQALHP----- 439

  Fly   520 SADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPE 584
                                   ||.|..:..:..:..|      .:|.|||....|..:.....
Mouse   440 -----------------------SAGQPGLETEAAAREP------ESGPGSGDEAGGLPQGHSGT 475

  Fly   585 VPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNS 649
            :......:|.|...|.:.:...|    :|...|  |..|:....|      ::.:...||:...:
Mouse   476 LMMAFRDVTVQIANQNISVSSST----ALSVAN--CLGAQTAQAT------AEPAAAQAEQEDTA 528

  Fly   650 DLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVA------ 708
            |  .:.|..|          :|:|....|.||..|.|  ....|....|..|.::.|||
Mouse   529 D--QEVSEVP----------ASEQMDPPSEDSEAAES--RAQSAQEPAVAQAVVEEAVATEAEEE 579

  Fly   709 ---------AATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAA---------AGV 755
                     .|.|.||.......:.|:.|.:|:..........::.|||...:         |..
Mouse   580 EEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKEALQAVILSLPRYHCENPASC 644

  Fly   756 AQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYL 820
            ......::|:|||.||:||||||..|:|||.:||.|||:.:||.|||.||:.|||||||||||:|
Mouse   645 RSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFL 709

  Fly   821 GNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIV 885
            ||.:.|||..||.|...|:|.|..::|.|||||||:.|:.|||||:|||:|.||||||.||.::|
Mouse   710 GNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 774

  Fly   886 GRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVK 950
            .:..:.||||:||||||:||||:::||:||:|:|.:||||:||||:||..||.:::::|||:|::
Mouse   775 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQ 839

  Fly   951 SDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFND 1015
            ..|.|...||||.|.||:.:|||.|..|::|||||||..||:|:.||||.::...||||||||||
Mouse   840 QKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFND 904

  Fly  1016 LLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDG---KILITFNARNEH 1077
            ||||.|:..|||:|.||||..:..|.|....|.:...|...|.|:..:.|   |.::.|.|....
Mouse   905 LLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSD 969

  Fly  1078 DRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQA 1142
            :..||.|||||||:|:.|:|.:|||.|||:|:..:..:..:|                   |:|.
Mouse   970 EMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSVRSA-------------------GAQG 1015

  Fly  1143 SGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQSTTTSSASREN 1207
            .    |.|...|...||.|::          |.:..:..|.| |:.:.:..|           ::
Mouse  1016 D----PQSKQGSPTAKREAMA----------GEKAAESSGEV-SIHNRLQTS-----------QH 1054

  Fly  1208 AAAIAAAANAAAAAKMRFNMPPTAAIATPSNVYAAP 1243
            :..:.....|.|.:      |||:....|.:...:|
Mouse  1055 SPKLGVERGAPAPS------PPTSPPPLPPDPQPSP 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	113/187 (60%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	65/129 (50%)
Iqsec3	NP_001028526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..139		24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..272		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..474		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..615		25/112 (22%)
		Sec7	655..843	CDD:279680	113/187 (60%)
		PH_IQSEC	870..1000	CDD:270128	65/129 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1100		21/132 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838940
Domainoid	1	1.000	262	1.000	Domainoid score	I1930
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1176
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360558at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X920
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.950