DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and PSD4

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_036587.2	Gene:	PSD4 / 23550	HGNCID:	19096	Length:	1056	Species:	Homo sapiens

Alignment Length:	986	Identity:	206/986 - (20%)
Similarity:	326/986 - (33%)	Gaps:	330/986 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 QQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTV 471
            |:|.:....|..|....|...:  |:..|......:.||.||...||       .||.:
Human    88 QEQTRATDPPESTRQDAPPWGS--GVELTHLGSPSAQREHRQNTASP-------GSPVN------ 137

  Fly   472 STSALASHPHVN------------LLHA------AEPHYYNAQALPQGAAYY-----------TS 507
              |.|...|..|            :|.|      .|......:.|..|....           |.
Human   138 --SHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTG 200

  Fly   508 YHGSP---HDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSG 569
            .|.||   .|....||.......:|:. .|....:|.:.|.:..|.........:| ||.::.||
Human   201 LHSSPPENEDSGEDSSEPEGEGQAWLR-EGTPDSSPQWGAEEESMFFSNPLFLASP-CSENSASG 263

  Fly   570 S----GGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQ-------------TPP-PPSLLRT 616
            .    |.|.|.:..:..||.| .|......:.|.|..|:.:             ||| |..:.:.
Human   264 ECFSWGASDSHAGVRTGPESP-ATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKP 327

  Fly   617 NGLC---KTAENGSLTSVQSSGS----------------DSSVTSAERNLNSDLGSD-------R 655
            :.:|   ..|..|:..:....|.                |.::|.....:.||||..       .
Human   328 HSICWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWA 392

  Fly   656 SNSPHTWKRG------TALN-----------------------------SSQQFSTHSADSAG-- 683
            |.||..|:||      ..||                             ||.:.|:..::|.|
Human   393 SLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPG 457

  Fly   684 -----AVSGGG--------VGVAGGAGVYAAQM--------QAAVAAATAAGGMP---------- 717
                 |.|..|        .|:.....:.|:|.        |.:......||..|
Human   458 PRPSPASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEG 522

  Fly   718 ---PAD--DHAISSHTSAAQYEQ----------------HEQQQHEQQQLQAAAAAAGVAQNYKM 761
               ||:  |.....|.::|::|.                ..|...|.|:..|....|...:|.|:
Human   523 TARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKV 587

  Fly   762 SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQ 826
            :..:..|.||:                  .||.::.   ||.:|......||.:..|||...|
Human   588 AWNLASRLYRL------------------EGFRKSE---VAAYLQKNNDFSRAVAEEYLSFFQ-- 629

  Fly   827 FNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSS 891
                          ..|:.:|.|||.|.....:.||.|:.||::..||:|:..||.   |...|.
Human   630 --------------FGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNP---GIFPSV 677

  Fly   892 DTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSD--EF 954
            |::..|..||::||||||..|:  .:.|..::||.||.|:.|..:..|::|..:|..::|:  |:
Human   678 DSVHTLTCAIMLLNTDLHGQNI--GKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEW 740

  Fly   955 KPGSDHVTQVMKVQATI-VGK--KPNLAL-------PHRRLVCYCRLYEIPDVNKKERPGVHQRE 1009
            ....:...:..|.|.:: .||  ||.|.|       .:::.:...::::  |.:.|:.|. .:|.
Human   741 AVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQ--DADGKKTPW-GKRG 802

  Fly  1010 VFLFNDLLVITKIFSKKKTSVTYTFRNSFPLC----GTVVTLLDMP------------NY---PF 1055
            ..:|:.||         :..|.|..:.....|    ..|..::|.|            :|   |.
Human   803 WKMFHTLL---------RGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPH 858

  Fly  1056 CIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAE 1120
            ..|| :..|.::.: |.|..       |:::...|:.::             ..:|.:.||
Human   859 VFQL-RTADWRLYL-FQAPT-------AKEMSSWIARIN-------------LAAATHSAP---- 897

  Fly  1121 NRDSGVADVEVCPCPYQQGS--------------QASGEQAPNSADNSQQLKRSALSNSLLDMHE 1171
                        |.|...||              |:|.|:...|.:|.    ..|.::.|||:..
Human   898 ------------PFPAAVGSQRRFVRPILPVGPAQSSLEEQHRSHENC----LDAAADDLLDLQR 946

  Fly  1172 QFGNEKPQRRG 1182
            ..    |:|||
Human   947 NL----PERRG 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	54/189 (29%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	22/145 (15%)
PSD4	NP_036587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..149		19/77 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..239		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..362		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..533		26/144 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..581		5/34 (15%)
		Sec7	570..738	CDD:238100	59/209 (28%)
		PH_EFA6	772..900	CDD:270107	26/177 (15%)
		PH	794..892	CDD:278594	21/129 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740