Protein Alignment siz and Psd3

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_036009810.1
• Gene: Psd3 / 234353
• MGIID: 1918215
• Length: 1303
• Species: Mus musculus
• Alignment Length: 1397
• Identity: 267/1397 - (19%)
• Similarity: 450/1397 - (32%)
• Gaps: 481/1397 - (34%)

  Fly    50 VAPPGPV-----SLPLPLSINMPHHHV---HAMPYNVDELLRENNALHAKIKE--LSLERDRLLC 104
            :|.|.|.     |.|   ||...|..|   |...:::|...|  ||:...:.:  ||...||
Mouse   146 LASPAPTLNDRNSSP---SIGWKHRPVISAHGDLWDMDPEAR--NAIEFSVPQSTLSYAADR--- 202

  Fly   105 EVSNLRLELDMSELKRLPVDLDDNFPQKSLERSGSTQYELAGAQQPGSANASTCTDSGSVGGYVY 169
                                     .:::|:|.|:...|:.         ...|.:  .:|..|.
Mouse   203 -------------------------GKRALQRRGTVNQEVL---------PKNCEE--DIGTTVL 231

  Fly   170 LQN----HYAPGAHSSSAAINYPAQQHPQMVYQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHYMQ 230
            ...    .|.|....|.:.:..||           ..|          |:.:..:....|..:.|
Mouse   232 ATRAQLFRYCPTIQISQSCLAPPA-----------AVP----------LKAEPFVWVNSASAHSQ 275

  Fly   231 VTATGGGQYHHHHMLHGHGHH----AHHHGGAVVI----------------AGSGVGTGLGSGAT 275
            ..|..     .:..|.|....    :..|||:.::                .|.|:...|...|.
Mouse   276 SVAKA-----KYEFLFGKSEEKTPDSSDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAK 335

  Fly   276 SVIMQHQQQQQQQQNMHK-------KNSIRNGGDVLKRTRAQSAYELSQDLLEKQIELLERKYGG 333
            |    ...:...||.:|.       .||:..|.:...:...|   |.|...::..|..|:    .
Mouse   336 S----PPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQ---EQSLQPIDSLISALK----A 389

  Fly   334 VRARNAAVTIQRA--------FRHYMMVKKFAS-----------------------ITAMAKAEK 367
            ..||.|:.|.|..        |..|.:.|:.::                       ::|....|:
Mouse   390 TEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPLSAEVPTEE 454

  Fly   368 RLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGL 432
            .||..:....|:| |.||        ..|..||:|..::|...      ||...|.|..::|.|
Mouse   455 NLSLHIQEDLSAL-LPEE--------AQAHRSQITNYRRQGPL------RVPESACPVSSSSAG- 503

  Fly   433 SRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQA 497
            |..|..|..::||:|    |.:.|                     .||.         .|....:
Mouse   504 SHNPVDRVGALREQR----SDLGR---------------------EHPR---------GYDRGGS 534

  Fly   498 L-PQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAA----QIYMRPKGGSTT 557
            : .||...:..:.|              :...|......|.|.|..:|:    :...||...|
Mouse   535 MGRQGRIKHVEFQG--------------VEILWTGEEAESRHPPERTASPVSKEFAKRPSHSS-- 583

  Fly   558 PTPSCS-GSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNG--- 618
              |:|. .||.:...|.....:.|.|.|.| .||:.|.            :|.|   |..:|
Mouse   584 --PACGVCSTSTHLTGDVWDETCKAPSERP-GTSAGTL------------SPMP---LGESGEDD 630

  Fly   619 -LCKTAENGSLTSVQSSGSDSSVTSAERNLNSD---LG---SDRSNSPHTWKRGTAL-NSSQQFS 675
             ..:.::.....:....|....:...|.:|..|   ||   ::.|...::.:..|.| |:|..:|
Mouse   631 VFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVYSSQFETILDNTSLYYS 695

  Fly   676 THSADSAGA-------------------VSGGG-----VGVAGGAGVYAAQMQAAVAAATAAGGM 716
            ..|.::..:                   :..||     ..|.|...|.:......:....:||..
Mouse   696 AESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGIT 760

  Fly   717 PPADDHAISSHTSAAQYEQHEQQQHE------QQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLN 775
            ....|.|.|.:|...|         |      :.:..|.....||....:|..|          :
Mouse   761 NGLHDSANSVYTRGPQ---------EIAFWGSRDRCFAEGKTTGVDAGSEMGST----------D 806

  Fly   776 LFNKKPEKGITYLIRRGFLEN--TPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAME 838
            :.    ||..|..:..|...|  ..:.:|:.|.......|..:.::||. .|:|:..|...:...
Mouse   807 IL----EKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGK-NNEFSKLVAEEYLKF 866

  Fly   839 LDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIM 903
            .|.:|..:|.:||.|...|.:.||.|:.||::..||.||..||.|.:   .|.|.:..|..|:::
Mouse   867 FDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNPDTI---TSKDGVHCLTCAMML 928

  Fly   904 LNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQ 968
            ||||||..|:  .::|..::||.||:|:::..|..||:|..:|:.:|:::.:
Mouse   929 LNTDLHGHNI--GKKMTCQEFITNLQGVNEGGDFSKDLLKALYNSIKNEKLE------------- 978

  Fly   969 ATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERP---------GVHQREVFLFNDLLVITKIFS 1024
                                   :.:.|..||:.|         |.|.:         .|::|.|
Mouse   979 -----------------------WAVDDEEKKKSPSEGTDEKANGTHPK---------TISRIGS 1011

  Fly  1025 KKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQ-----LSQKV----DGK-------------- 1066
                              |....||:|:.|....     |::|:    |||
Mouse  1012 ------------------TTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYA 1058

  Fly  1067 IL---ITFNARNEH--DRCKFAEDLKESISEMDEMESLRIEAELE----RQKSA-------RNRA 1115
            :|   :.:..::|:  ::....||||.::|....:.|...:.|.:    :.|:|       :.::
Mouse  1059 VLKGTVLYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQS 1123

  Fly  1116 PGNAE---NRDSGVADV-EVCPCPYQQGSQ---------------ASGEQAPNSADNSQQLKRSA 1161
            |...:   |:.:.||.| ...|.|...|||               :..||..:.....:|:....
Mouse  1124 PEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTEL 1188

  Fly  1162 LSN-----------------SLLDMHEQF----------GNEKPQRRGS--------VGSLDSGM 1191
            ..:                 .|.|.:.:|          |||.|..|..        :|.:.:.:
Mouse  1189 AEHRSYPPDKKVKAKDVDEYKLKDHYLEFESLGQNQHSGGNELPSERKHLLFCTRLLLGDISALL 1253

  Fly  1192 SISFQ-STTTSSASRENAAAIAAAANAAAAAK 1222
            ||:.: :....:|.|...:.|....||:...:
Mouse  1254 SIAHRHALQEGTAERRLGSFILNDMNASVVRR 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	55/189 (29%)
		PH_IQSEC	981..1108	CDD:270128	28/167 (17%)
Psd3	XP_036009810.1	Sec7	823..977	CDD:238100	51/159 (32%)
		PH_EFA6	1022..1147	CDD:270107	23/124 (19%)