DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment siz and IQSEC2

DIOPT Version :9

Sequence 1:NP_730594.1 Gene:siz / 40327 FlyBaseID:FBgn0026179 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_006724642.1 Gene:IQSEC2 / 23096 HGNCID:29059 Length:1520 Species:Homo sapiens


Alignment Length:1555 Identity:460/1555 - (29%)
Similarity:644/1555 - (41%) Gaps:451/1555 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 GNQGGPGGSAGGVAPPGPVSLPLPLSINMPHHHVHAMPYNVDELLRENNALHA----------KI 92
            |..||||..:...|                          |:.||..||.:.:          :|
Human     6 GPPGGPGSESPNRA--------------------------VEYLLELNNIIESQQQLLETQRRRI 44

  Fly    93 KELSLERDRLLCEVSNLRLE--LDMSELKRLPVDLDDNFPQKS-LERSGSTQY---ELAGAQQPG 151
            :||..:.|:|..|..:||.|  |...||.|.|....|:..::| .:....||:   ||..:|   
Human    45 EELEGQLDQLTQENRDLREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQ--- 106

  Fly   152 SANASTCTDSGSVGGYVYLQNHYAPGAHSSSAAINYP----AQQHPQMVYQIQQ----YP----- 203
                                      .|.::..:.||    |.|:.:.||:.::    ||     
Human   107 --------------------------FHQAARDVGYPNREGAYQNREAVYRDKERDASYPLQDTT 145

  Fly   204 ----------TCHQQQQQQHLQQQQHLHQTGAGH--------YMQVTATGGGQYHHHHMLH---- 246
                      .||...:...|.:::...:.|..|        |......|.........|.    
Human   146 GYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGAS 210

  Fly   247 -------GHGH-----------------------------HAHHH---------------GGAVV 260
                   |.||                             |..|.               .|.  
Human   211 RSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGR-- 273

  Fly   261 IAGSGV-GTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGG----------------------- 301
            :|.|.| |...||..::.:.....|...:.:....:|...||                       
Human   274 LAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALR 338

  Fly   302 ----DVLKRTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASIT 360
                :.:||::|.| :||||.||.:|::|:||||||| ..:|.||.|||.|||.|.|.|.|..:.
Human   339 KQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLR 403

  Fly   361 AMAKAEKRLSRRMVVT--ASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAG 423
            :.| :|.|:|||::::  .......|...:.:.||.....:.|.|                  ..
Human   404 SSA-SESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDE------------------GA 449

  Fly   424 PAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASI--SSSTVSTSALASHPHVNLLH 486
            .|||.|..|.|..|                    ..|:....|  ..|:|:||...|:....|  
Human   450 MAGARSHRLERGLP--------------------YGGSCGGGIDGGGSSVTTSGEFSNDITEL-- 492

  Fly   487 AAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRP 551
              |..:                  |....|.|.|.|.:||.   :.||.....|  .:||:..|.
Human   493 --EDSF------------------SKQVKSLAESIDEALNC---HPSGPMSEEP--GSAQLEKRE 532

  Fly   552 KGGSTTPTPSCSGSTGSGSGGSGSGSS-------KKVPPEVPKRTSSITAQQQTQLLL-----LQ 604
                         |.......|.:..|       ..||.:.|:|..|.....|.:...     |.
Human   533 -------------SKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLP 584

  Fly   605 RQTPPPPSLLRTNGLCKTAENGS--------------------LTSVQSSGSDSSVTSAERNLNS 649
            ...||.||..|.:|   :.|.|:                    |.:::.. |||||..::|   |
Human   585 PVPPPVPSGTREDG---SREEGTRRGPGCLECRDFRLRAAHLPLLTIEPP-SDSSVDLSDR---S 642

  Fly   650 DLGSDRSN--------SPH-TWKR----GTALNSSQQFSTHS------------ADSAGAVSGGG 689
            |.||....        ||| |.|.    |.|....:.:....            |.::|.   |.
Human   643 DRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGT---GP 704

  Fly   690 VGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAG 754
            .|||||..:...:    .|...:.||    |:.::.|.:::.:..........:..|:...|...
Human   705 SGVAGGRRLGKCE----AAGENSDGG----DNESLESSSNSNETINCSSGSSSRDSLREPPATGL 761

  Fly   755 VAQNYKM------------SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLIT 807
            ..|.|:.            ::.:::|.||:|||||||||||||.|||.||||.:||.|||.|::.
Human   762 CKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILE 826

  Fly   808 RKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEI 872
            |||||||||||:|||.|.|||..||.|...|:|.|...:|.||||||::.|:.|||||:|||:|.
Human   827 RKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 891

  Fly   873 FSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDI 937
            ||||||.||..:|.:.|:.||||:||||||:||||:::|::|.||:|:::||||||||:|:..||
Human   892 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDI 956

  Fly   938 DKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKER 1002
            .:|:|:|||.|::..|.:...|||:||..|:..||||||.|:||||||||.|:|||:||.|:.:|
Human   957 PRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQR 1021

  Fly  1003 PGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDG-- 1065
            .|:|||||||||||||:||||.|||..|||:||.||||....:.|.....|.|.|:|...|.|  
Human  1022 LGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGE 1086

  Fly  1066 -KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKS-ARNRA--PGNAENRDSGV 1126
             |:||.|||.:..||.:|..||:|||:|:.|||..|:|:|||:||. .|..|  ||.|::..:|.
Human  1087 RKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGT 1151

  Fly  1127 ADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGM 1191
            .            :::|.|....:.|.   |||.|||:||.|:.:.   .|..||.|||||||.:
Human  1152 M------------ARSSLEDTYGAGDG---LKRGALSSSLRDLSDA---GKRGRRNSVGSLDSTI 1198

  Fly  1192 SISFQSTT------------------TSSASRENAAAIAAAANAAAAAKMRFNMPP------TAA 1232
            ..|..|:.                  .|.....|:::...:...:...|..|.|||      :|:
Human  1199 EGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASAS 1263

  Fly  1233 IATPSNVY----------------AAPGMQA---YTHANFVQQSQAA---YMLQQQQMLQQQAQM 1275
            .::.|:.:                ..|..|:   ..||.:.|....|   |:..||..|....| 
Human  1264 SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQ- 1327

  Fly  1276 QAQAQAQAQAQAQAQAQAQAQAQAQPL--------TGRIP-------GRERKASRTDENG 1320
                  |.....|..:.....|.|.|:        .|.:|       ||..:|.|....|
Human  1328 ------QPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGG 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sizNP_730594.1 Sec7 766..954 CDD:279680 116/187 (62%)
PH_IQSEC 981..1108 CDD:270128 75/129 (58%)
IQSEC2XP_006724642.1 ATG16 <23..>64 CDD:312208 12/40 (30%)
Sec7 785..973 CDD:307500 116/187 (62%)
IQ_SEC7_PH 996..1125 CDD:318620 73/128 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148864
Domainoid 1 1.000 265 1.000 Domainoid score I1905
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 517 1.000 Inparanoid score I1289
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D360558at33208
OrthoFinder 1 1.000 - - FOG0002052
OrthoInspector 1 1.000 - - otm41445
orthoMCL 1 0.900 - - OOG6_104559
Panther 1 1.100 - - LDO PTHR10663
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4991
SonicParanoid 1 1.000 - - X920
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1111.020

Return to query results.
Submit another query.