DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment siz and MON2

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_016874530.1	Gene:	MON2 / 23041	HGNCID:	29177	Length:	1718	Species:	Homo sapiens

Alignment Length:	752	Identity:	143/752 - (19%)
Similarity:	255/752 - (33%)	Gaps:	210/752 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 VNLLHAAEPHYYNAQAL---------PQ-GAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHS 536
            |..|.|.:|.:..|.|:         || ..::..||....|        .|.:....||..|
Human   340 VKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQH--------STKVFRDIVNALG-- 394

  Fly   537 PHTPYYSAAQ-IYMRPKGGSTTPTPSCSGSTGSGS-GGS----------GSGSSKKVPPEVPKRT 589
                  |..| :::.|..|:    |:.|...|:.: |||          |.|....:.|....|.
Human   395 ------SFIQSLFLVPPTGN----PATSNQAGNNNLGGSVSAPANSGMVGIGGGVTLLPAFEYRG 449

  Fly   590 S-----SITAQ---QQTQLLLLQRQTPP--PP------------SLLRTNGLCKTAEN--GSL-T 629
            :     :||.|   :.|.|.:|.:..||  |.            .|:|  |:....|.  |.| |
Human   450 TWIPILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVR--GITSMIEGELGELET 512

  Fly   630 SVQSS---GSDSSVTSAERNLNSDLGSDRSN----SPHTWKRG---------TALNSSQQFSTHS 678
            ..|::   ||..:.::.:::|.|.  ||:.:    |...|:..         .||:.....||..
Human   513 ECQTTTEEGSSPTQSTEQQDLQST--SDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDE 575

  Fly   679 ADSAGAVSG--GGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQH 741
            |.:...:..  ....:.|..|:..:  :.|...|...|.:||.....:.:.|:||..........
Human   576 AATENILKAELTMAALCGRLGLVTS--RDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSVQ 638

  Fly   742 EQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLI 806
            .|..:..:.::....|...:.:.:..:                             |||..  ::
Human   639 GQSVMMISPSSESHQQVVAVGQPLAVQ-----------------------------PQGTV--ML 672

  Fly   807 TRKGLS--RQMI------GEYLGNLQNQFNMAVLSCFAMELDLS---------GRQVD--VALRK 852
            |.|.:.  |.::      |..||. ..|..:|.|......|.|.         ||.|:  ..:..
Human   673 TSKNIQCMRTLLNLAHCHGAVLGT-SWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLT 736

  Fly   853 FQAYFRMPGEAQKIERLMEIFSQRYCE-----------CN-----ADIVGRLRSSDTIFVLAFAI 901
            ......:|..:..:.||.|  |.:|.:           |:     .|:........::|.:|..:
Human   737 TAVMTDLPVISNILSRLFE--SSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLL 799

  Fly   902 IMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMK 966
            .....::|          |:|...:.|.|    |.::|     :.....|...:.|::.:|.::|
Human   800 ETGLVNMH----------RIEILWRPLTG----HLLEK-----VCQHPNSRMREWGAEALTSLIK 845

  Fly   967 VQATIVGKKPNLALPHR-RLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLL------------- 1017
            ...|. ...|.|:...| :|:....|.|:.::|   .|.:..:::.....:|
Human   846 AGLTF-NHDPPLSQNQRLQLLLLNPLKEMSNIN---HPDIRLKQLECVLQILQSQGDSLGPGWPL 906

  Fly  1018 ---VITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYP-FCIQLSQKVDGKILITFNARNEHD 1078
               |:..|.:.:..|:   .|.:|.....|||.. :|..| .|:|:...|.|    :|...|:..
Human   907 VLGVMGAIRNDQGESL---IRTAFQCLQLVVTDF-LPTMPCTCLQIVVDVAG----SFGLHNQEL 963

  Fly  1079 RCKFAE-DLKESISEMDEMESLRIEAELERQKSARNR 1114
            ...... .|..:||:........||.||.::::|:.:
Human   964 NISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQK 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	35/222 (16%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	30/145 (21%)
MON2	XP_016874530.1	DCB	9..183	CDD:292830
		Sec7_N	212..379	CDD:289549	10/38 (26%)
		DUF1981	<873..932	CDD:286414	8/64 (13%)
		Mon2_C	935..1709	CDD:292823	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900