DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Psd4

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001342160.1	Gene:	Psd4 / 215632	MGIID:	2674093	Length:	1005	Species:	Mus musculus

Alignment Length:	987	Identity:	199/987 - (20%)
Similarity:	326/987 - (33%)	Gaps:	331/987 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 SRRMVVTASSLGLAEEGASSSSA---YGSATESQLTEQQQQQQAQQQQQPRVTI---MAGPAG-- 426
            |.|.:...||||..::..|||:.   :....::|:.....:::.::.:..|..:   :..|:.
Mouse    85 SLRSLEDNSSLGSPQQNQSSSTQVVFWAGILQAQMCVLDLEEELEKTEGLRAELRCCIPPPSKDL 149

  Fly   427 AASPGLSRTPPTR--------SLSMRERRQLDCSPIPRS-------------------QSGASPA 464
            ....|||.:.|..        |....|.:......||.|                   :|..|..
Mouse   150 LGDEGLSPSRPEEDEDSGDDSSGPEEENQTWPREKIPGSSLEWGAEEDSIFFDNPLFLESPCSDT 214

  Fly   465 SISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASW 529
            |......|.....|||.:.                       ::|.||..|.......|.|   |
Mouse   215 STEGECFSWGYPNSHPDMK-----------------------TWHQSPQTLDSPLQKGTGL---W 253

  Fly   530 ---------VNTSGHSP-HTPYYSAAQIYMRP-------KGGSTTPTPSCSGSTGSGSGGSGSGS 577
                     .:|:.|.. .||.:......|.|       :|..|.| |...|.| |.....|.||
Mouse   254 RQENELDLGSDTADHGGCSTPPFPVPSYKMHPCLALGSTEGDPTVP-PDQEGET-SCEDDLGHGS 316

  Fly   578 SK-------------------------KVPPEVPKRTSSITAQQQTQLLLLQRQTP--PPPSLLR 615
            .|                         .|.|...:.:.|::...|..|..|||:.|  ...:|:.
Mouse   317 PKAPFVDHELIQESDNFEFDLRPATTHPVQPWGSQTSQSLSDLTQPILEDLQREDPSRSQETLIS 381

  Fly   616 TNG------------LCKTAENGSLTSV----------QSSGSDSSVTSAERN-----LNSD--- 650
            .|.            .|..|..||.||:          :.||...|..|::.:     |:|.
Mouse   382 QNRGERDAGCFQEPVFCTLAPWGSQTSLLEPNCPESEGRGSGPQPSPVSSQDSSPRVLLHSPKWP 446

  Fly   651 ------LGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAA 709
                  |..|||.          |:|.::..|....|.                    .|.|
Mouse   447 QDASHLLQKDRSE----------LSSLKEEETEEVPSL--------------------RQEA--- 478

  Fly   710 ATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGL 774
                    ..:|.:.|...||.|:..|            .|:|.|:.:: .|.:.
Mouse   479 --------ECEDTSRSEDASANQHHVH------------LASAEGLPES-PMPQA---------- 512

  Fly   775 NLFNKKPEKGITYLIRRGFLENTPQ------GVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLS 833
                :.||:|......|..|.|..:      .:|..|....|..:..:..:| ...|.|:.||..
Mouse   513 ----QSPEEGWRPSSSREKLANDIRNDKGAWNLALRLYQLNGFRKSEVAAHL-RKNNDFSRAVAE 572

  Fly   834 CFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLA 898
            .:.......|:.:|.|||.|.....:.||.|:.||::..||:|:..||.   |...|.|::..|.
Mouse   573 AYLSFFQFEGQSLDRALRGFLQALVLSGETQERERILYQFSKRFHYCNP---GAFPSVDSVHTLT 634

  Fly   899 FAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEF--------- 954
            .||::||||||..|:  .:.|..::|:.||.|:.|..:..|::|..:|..::|::.
Mouse   635 CAIMLLNTDLHGQNI--GKSMSCQEFVTNLNGLQDGRNFPKELLKALYWSIRSEKLEWAIDEEDA 697

  Fly   955 -KPGSDHVT-QVMKVQATIVGKKPNLALP-HRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDL 1016
             :|..|..: ...|:.:..:....:..:| :::.:...:::.|.| .||...|  :|...:|:.|
Mouse   698 DRPEKDQPSPSAGKISSPFLQMAQDPTMPTYKQGILARKMHHIAD-GKKTPWG--KRGWKMFHTL 759

  Fly  1017 LVITKIFSKKKTSVTYTFR------NSFPLCGTVVTLLDMP------------NY---PFCIQLS 1060
            |         :..|.|..:      :...|.|.:|   |.|            :|   |...||
Mouse   760 L---------RGMVLYFLKGEGQWLDGESLVGHMV---DEPVGVHHSLASPATHYTKKPHVFQL- 811

  Fly  1061 QKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSG 1125
            :..|.::.: |.|..       |:::...|:.::             ..:|.:.||
Mouse   812 RTADWRLYL-FQAPT-------AKEMASWIARIN-------------LAAATHSAP--------- 846

  Fly  1126 VADVEVCPCPYQQGS--------------QASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNE 1176
                   |.|...||              |:|.|:...|.:|.    ..|.|:.|||:....
Mouse   847 -------PFPAAVGSQRRFVRPILPMSPVQSSLEEQHRSHENC----LDAASDDLLDLQRNL--- 897

  Fly  1177 KPQRRGSVGSLD 1188
             |:|||....|:
Mouse   898 -PERRGRSRELE 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	53/193 (27%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	26/148 (18%)
Psd4	NP_001342160.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..189		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..386		22/100 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..525		31/185 (17%)
		Sec7	510..688	CDD:238100	53/197 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..714		3/19 (16%)
		PH_EFA6	722..849	CDD:270107	30/179 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..1005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830