DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and Arfgef1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001095900.1	Gene:	Arfgef1 / 211673	MGIID:	2442988	Length:	1846	Species:	Mus musculus

Alignment Length:	841	Identity:	203/841 - (24%)
Similarity:	324/841 - (38%)	Gaps:	207/841 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 RAQSAYELSQDLLEKQIELLERKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRR 372
            ||..:....:.|:::.||.:...:.|.:. :..|.:|       ::|  |.:||:......:...
Mouse   115 RAPDSTTPGKKLIDRIIETICGCFQGPQT-DEGVQLQ-------IIK--ALLTAVTSQHIEIHEG 169

  Fly   373 MVV----TASSLGLAEEGASSSSAYGSATESQL-------TEQQQQQQAQQQQQPR----VTIMA 422
            .|:    |..::.||.:...:.:. ..||.:|:       .|.|..|:|:|.::.|    ..::.
Mouse   170 TVLQAVRTCYNIYLASKNLINQTT-AKATLTQMLNVIFARMENQALQEAKQMERERHRQQQHLLQ 233

  Fly   423 GPAG---AASPGLSRTPPTRSLSMRERRQLDCSP----IPRS-QSGASP---ASISSS----TVS 472
            .|..   ..||.|...||.....:.:..:.|..|    :.:| |....|   :.|||:    |.:
Mouse   234 SPVSHHEPESPHLRYLPPQTVDHINQEHEGDLEPQTHDVDKSLQDDTEPENGSDISSAENEQTEA 298

  Fly   473 TSALASHPHVNLLHAAEPHYYNAQALPQGAAYYT-SYHGSPHDL------------------SYA 518
            ..|.|                 |:.|.:....|. .|...|.|:                  ..|
Mouse   299 DQATA-----------------AETLSKNDILYDGDYEEKPLDIVQSIVEEMVNIIVGDMGEGMA 346

  Fly   519 SSADTSLNASWVNTSGHS--------PHTPYYSAAQIYMRPK---GGSTTPTPSCSGSTGSGSGG 572
            .||.|..|...|.....|        |.|| .|.|.....|.   ..|:..|.....|:|...|.
Mouse   347 ISASTEGNTGTVEDGSDSENIQANGIPGTP-ISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGA 410

  Fly   573 SGSGSSKK-------------------VPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNG 618
            ..|...:|                   .||: ||.....:.....||||...|...|  :.|||.
Mouse   411 KFSHILQKDAFLVFRSLCKLSMKPLSDGPPD-PKSHELRSKILSLQLLLSILQNAGP--VFRTNE 472

  Fly   619 LCKTAENGSLTSVQSSGSDSSV---------------TSAERNLNSD------------LGSDRS 656
            :...|....|....|....|||               ::.:.:|...            |.:..|
Mouse   473 MFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS 537

  Fly   657 NSPHTW---------------------KRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYA 700
            :..|.|                     .....||::..|.....|.:....|.|....|.:.|..
Mouse   538 SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQE 602

  Fly   701 AQ-----MQAAVAAATAAGGMPPADDHAI--SSHTSAAQYEQHEQQ----QHEQ--------QQL 746
            ..     ::..|:.....  :..:.|..:  :|.|:..|.:..||:    :|.:        ..|
Mouse   603 LSLRKKGLECLVSILKCM--VEWSKDQYVNPNSQTTLGQEKPSEQEISEVKHPETINRYGSLNSL 665

  Fly   747 QAAAAAAGVAQNYKMSETIRKRQYRV----------GLNLFNKKPEKGITYLIRRGFLENTPQGV 801
            ::.:::...:.:.:||.|....|:.|          |::||||||::||.||..:|.|..||:.:
Mouse   666 ESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDI 730

  Fly   802 ARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKI 866
            |:||...:.|....:||:||: .::||..|:..:..:.|.||:....|||.|...||:|||||||
Mouse   731 AQFLHQEERLDSTQVGEFLGD-NDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQKI 794

  Fly   867 ERLMEIFSQRYCECNADIVGR--LRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLR 929
            :||||.|:.||.|||.   |:  ..|:||.:|||::||||.||||:|.:|  .:|..|.:||..|
Mouse   795 DRLMEKFAARYLECNQ---GQTLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNR 854

  Fly   930 GIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGK--KPNLALPHRRLVCY 988
            ||:|..|:.::.|..||:.:...:       ::.....:.||..|  |.|:|...:|.:.|
Mouse   855 GINDSKDLPEEYLSAIYNEIAGKK-------ISMKETKELTIPTKSTKQNVASEKQRRLLY 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	83/199 (42%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	2/8 (25%)
Arfgef1	NP_001095900.1	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224		24/119 (20%)
		PLN03076	15..1763	CDD:215560	203/841 (24%)
		DCB	29..210	CDD:292830	19/105 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..249		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..304		11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..410		16/63 (25%)
		Sec7_N	416..570	CDD:289549	25/156 (16%)
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	554..574		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..684		9/52 (17%)
		Sec7	695..879	CDD:279680	81/196 (41%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	708..712		3/3 (100%)
		DUF1981	1217..1298	CDD:286414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740