Protein Alignment siz and Cyth3

DIOPT Version :9

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_035312.3
• Gene: Cyth3 / 19159
• MGIID: 1335107
• Length: 399
• Species: Mus musculus
• Alignment Length: 369
• Identity: 109/369 - (29%)
• Similarity: 174/369 - (47%)
• Gaps: 93/369 - (25%)

  Fly   764 TIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFN 828
            |.|.:|..:|...||..|:|||.:||....|:::|:.||:||...:||::.:||:|||. ::.||
Mouse    64 TQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGE-RDDFN 127

  Fly   829 MAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDT 893
            :.||..|....:.:...:..|||:|...||:|||||||:|:||.|:.|||.||.   |..:|:||
Mouse   128 IKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNP---GVFQSTDT 189

  Fly   894 IFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFK--- 955
            .:||:||||||||.||..|::.  :...|.||...|||::..|:.:::|..:|:.:|::.||
Mouse   190 CYVLSFAIIMLNTSLHNHNVRD--KPTAERFITMNRGINEGGDLPEELLRNLYESIKNEPFKIPE 252

  Fly   956 -PGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVI 1019
             .|:|                    |.|        .:..||           ||.:|.
Mouse   253 DDGND--------------------LTH--------TFFNPD-----------REGWLL------ 272

  Fly  1020 TKIFSKKKT----------SVTYTF--------RNSFPLCGTVVTLLDMPNYPFCIQL------- 1059
             |:..:.||          :..|.|        |...||....:..::.|..|.|.:|
Mouse   273 -KLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKG 336

  Fly  1060 ------SQKVDGK------ILITFNARNEHDRCKFAEDLKESIS 1091
                  ..:.||:      ::...:|.:..::.::.:.:|.|||
Mouse   337 QVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASIS 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	78/187 (42%)
		PH_IQSEC	981..1108	CDD:270128	25/148 (17%)
Cyth3	NP_035312.3	Sec7	66..248	CDD:396096	78/187 (42%)
		PH_GRP1-like	263..382	CDD:269954	24/136 (18%)
		Phosphatidylinositol 3,4,5-trisphosphate binding	273..280		1/6 (17%)
		C-terminal autoinhibitory region	391..399

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740