DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment siz and Cyth1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001106170.1	Gene:	Cyth1 / 19157	MGIID:	1334257	Length:	400	Species:	Mus musculus

Alignment Length:	248	Identity:	95/248 - (38%)
Similarity:	148/248 - (59%)	Gaps:	18/248 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   724 ISSHTSAAQYEQHEQQQHEQQQLQA--------AAAAAGVAQNYKMSE----TIRKRQYRVGLNL 776
            :.|..:|.:.::.|..:..:|:|.|        .|..|...::...:|    ..|.:|..:|...
Mouse    10 VPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKK 74

  Fly   777 FNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDL 841
            ||..|:|||.:||..|.|:||.:.:|:||...:||::..||:|||. :::|::.||..|....:.
Mouse    75 FNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE-RDEFSIQVLHAFVELHEF 138

  Fly   842 SGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNT 906
            :...:..|||:|...||:|||||||:|:||.|:||||:||   .|..:|:||.:||:||||||||
Mouse   139 TDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCN---TGVFQSTDTCYVLSFAIIMLNT 200

  Fly   907 DLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSD 959
            .||.||:|.  :..||.||...|||:|..|:.:::|..:|:.:|::.||...|
Mouse   201 SLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPED 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	83/187 (44%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128
Cyth1	NP_001106170.1	DUF342	<8..90	CDD:302792	20/79 (25%)
		Sec7	64..246	CDD:279680	83/187 (44%)
		PH_GRP1-like	261..381	CDD:269954
		PH	265..379	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810