Protein Alignment siz and bris-1

DIOPT Version :10

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_500420.3
• Gene: bris-1 / 177142
• WormBaseID: WBGene00019726
• Length: 640
• Species: Caenorhabditis elegans
• Alignment Length: 899
• Identity: 255/899 - (28%)
• Similarity: 368/899 - (40%)
• Gaps: 294/899 - (32%)

  Fly   306 RTRAQSAYELSQDLLEKQIELLERKYGGVR-ARNAAVTIQRAFRHYMMVKKFASITAMAKA-EKR 368
            |...|..|:||.:|..:::::|||:|||:: |..||..||||:|.|.::|::..|...... ...
 Worm    15 RVFVQKGYQLSDELALRKVQVLERRYGGMQLAHRAATVIQRAWREYCIMKQWMVIRHKHDTIPDH 79

  Fly   369 LSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLS 433
            |..|..|:.|.    ....|.:|.|.::..:||...:                    .|.|..|.
 Worm    80 LDARCGVSNSQ----RNELSLTSRYATSLSAQLRIDR--------------------AARSTTLD 120

  Fly   434 RTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQAL 498
            |:||              ||.|                                  |...|.|
 Worm   121 RSPP--------------SPAP----------------------------------PVLVNLQ-- 135

  Fly   499 PQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCS 563
                                       |::.:::               .|.|:
 Worm   136 ---------------------------NSNMIDS---------------LMSPR----------- 147

  Fly   564 GSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSL 628
                .|:...|:.:|:..|     ..:.:|:   |::.|      |.|||:..|
 Worm   148 ----LGNRRFGAAASRCAP-----AAAELTS---TEVWL------PRPSLVNHN----------- 183

  Fly   629 TSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVA 693
                                                          ..||
 Worm   184 ----------------------------------------------PAHS--------------- 187

  Fly   694 GGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQN 758
                                ..:|..|.|.:                ||:.:.......:.|...
 Worm   188 --------------------NSLPRLDKHRV----------------HERSESSNGRKKSEVKPP 216

  Fly   759 YKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNL 823
            .:|::..||||||:.||.||||||:|:..|...||::|:|..:|..|..|:|||:.|||||:|.|
 Worm   217 RQMTDQERKRQYRIALNFFNKKPERGVQLLTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTL 281

  Fly   824 QNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRL 888
            .:.::..||..|...:|:.|.:|||||||...:|.:|.||:||:|:::.|:..|.:.|.......
 Worm   282 HSPYHSLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHY 346

  Fly   889 RSS-DTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGID------DCHDIDKDMLMGIY 946
            |.. |||.:|:|||||||||||:||:|  :||...||:|||||.|      :..|||:..|.|||
 Worm   347 RGGWDTIHLLSFAIIMLNTDLHSPNVK--QRMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIY 409

  Fly   947 DRVKSDEFKPGSDHVTQVMKVQATIVGK-KPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREV 1010
            ||:|.||.|.|.|||.||.:|...|||| ||.|....|||||||||.::.|..|::.....:|:|
 Worm   410 DRIKKDELKAGDDHVAQVQRVDRAIVGKDKPRLTETPRRLVCYCRLQQVSDPTKRQSSSARERDV 474

  Fly  1011 FLFNDLLVITKIFSKKKTSV---TYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFN 1072
            |||||::|:.|...:..||:   |||.:....|.|..||......|.|.:.::  ...|..|.||
 Worm   475 FLFNDMIVVAKGVRRGSTSMAGCTYTLKQWTLLLGAHVTEFQRGQYEFGLTIT--CPNKDKIHFN 537

  Fly  1073 ARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQ 1137
            |||..|||.|..|:.|||.|..|||.:|:|.|:|:..:...| |.|  .||||:.|::      :
 Worm   538 ARNFEDRCHFVADVTESIREATEMEQVRLEMEMEQHTTTTIR-PDN--QRDSGLPDMD------E 593

  Fly  1138 QGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGM 1191
            ....::|.   ||:..|.....:.::||..            ||.|..|||||:
 Worm   594 SMKLSNGS---NSSAGSSNSSTNGVNNSSF------------RRLSFNSLDSGV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:460178	95/194 (49%)
		PH_IQSEC	981..1108	CDD:270128	54/129 (42%)
bris-1	NP_500420.3	Sec7	224..417	CDD:238100	95/194 (49%)
		PH_IQSEC	445..573	CDD:270128	54/129 (42%)