Protein Alignment siz and Cyth2

DIOPT Version :9

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_446363.1
• Gene: Cyth2 / 116692
• RGDID: 620398
• Length: 400
• Species: Rattus norvegicus
• Alignment Length: 410
• Identity: 114/410 - (27%)
• Similarity: 195/410 - (47%)
• Gaps: 79/410 - (19%)

  Fly   737 EQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGV 801
            |.|:..::..:|.:...|:..|.......|.|:..:|...||..|:|||.:|:....|:|||:.:
  Rat    32 EIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEI 96

  Fly   802 ARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKI 866
            ||||...:||::..||:|||. :.:.|::||..|....:.:...:..|||:|...||:|||||||
  Rat    97 ARFLYKGEGLNKTAIGDYLGE-REELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKI 160

  Fly   867 ERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGI 931
            :|:||.|:||||.||.   |..:|:||.:||:||:|||||.||.||::.  :..:|.|:...|||
  Rat   161 DRMMEAFAQRYCLCNP---GVFQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGI 220

  Fly   932 DDCHDIDKDMLMGIYDRVKSDEFK----PGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLY 992
            ::..|:.:|:|..:||.::::.||    .|:|                    |.|        .:
  Rat   221 NEGGDLPEDLLRNLYDSIRNEPFKIPEDDGND--------------------LTH--------TF 257

  Fly   993 EIPDVNKKE---------RPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLL 1048
            ..||   :|         |....:|..|:..|..:....::..|..     |...||....:..:
  Rat   258 FNPD---REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP-----RGIIPLENLSIREV 314

  Fly  1049 DMPNYPFCIQL-------------SQKVDGKI------LITFNARNEHDRCKFAEDLKESIS--- 1091
            |.|..|.|.:|             ..:.||::      :...:|..:.::.::.:.::.::|
  Rat   315 DDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDP 379

  Fly  1092 --EMDEMESLRIEAELERQK 1109
              ||......||..:.::::
  Rat   380 FYEMLAARKKRISVKKKQEQ 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	79/187 (42%)
		PH_IQSEC	981..1108	CDD:270128	25/159 (16%)
Cyth2	NP_446363.1	Sec7	61..243	CDD:396096	79/187 (42%)
		PH_GRP1-like	258..378	CDD:269954	20/127 (16%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..276		1/7 (14%)
		C-terminal autoinhibitory region. /evidence=ECO:0000250	387..395		2/7 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740