DRSC/TRiP Functional Genomics Resources

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Protein Alignment siz and ARFGEF1

DIOPT Version :10

Sequence 1:NP_730594.1 Gene:siz / 40327 FlyBaseID:FBgn0026179 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001400123.1 Gene:ARFGEF1 / 10565 HGNCID:15772 Length:1864 Species:Homo sapiens


Alignment Length:707 Identity:174/707 - (24%)
Similarity:268/707 - (37%) Gaps:180/707 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   384 EEGASSSSAYGSATES-QLT-------------------EQQQQQQAQQQQQPRVTIMAGPAGAA 428
            |.|:..|||....||: |.|                   |::.|...|...:..|.|:.|..|  
Human   283 ENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMG-- 345

  Fly   429 SPGLSRTPPTRSLSMRERRQLDCSP---IPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEP 490
                            |...::.|.   |...:.|:...:|.::.:                   
Human   346 ----------------EGTTINASADGNIGTIEDGSDSENIQANGI------------------- 375

  Fly   491 HYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGS 555
                 ...|...||..|.   |.|....||.||..:.   |:||.||...:....|     |...
Human   376 -----PGTPISVAYTPSL---PDDRLSVSSNDTQESG---NSSGPSPGAKFSHILQ-----KDAF 424

  Fly   556 TTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLC 620
            ......|..|....|.|         ||: ||.....:.....||||...|...|  :.|||.:.
Human   425 LVFRSLCKLSMKPLSDG---------PPD-PKSHELRSKILSLQLLLSILQNAGP--IFRTNEMF 477

  Fly   621 KTAENGSLTSVQSSGSDSSV---------------TSAERNLNSD------------LGSDRSNS 658
            ..|....|....|....|||               ::.:.:|...            |.:..|:.
Human   478 INAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSF 542

  Fly   659 PHTW---------------------KRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQ 702
            .|.|                     .....||::..|.....|.:....|.|....|.:.|....
Human   543 DHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELS 607

  Fly   703 -----MQAAVAAATAAGGMPPADDHAI--SSHTSAAQYEQHEQQQHE------------QQQLQA 748
                 ::..|:.....  :..:.|..:  :|.|:..|.:..||:..|            ...|::
Human   608 LRKKGLECLVSILKCM--VEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLES 670

  Fly   749 AAAAAGVAQNYKMSETIRKRQYRV----------GLNLFNKKPEKGITYLIRRGFLENTPQGVAR 803
            .:::...:.:.:||.|....|:.|          |::||||||::||.||..:|.|..||:.:|:
Human   671 TSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735

  Fly   804 FLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIER 868
            ||...:.|....:||:||: .::||..|:..:..:.|.||:....|||.|...||:|||||||:|
Human   736 FLHQEERLDSTQVGEFLGD-NDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDR 799

  Fly   869 LMEIFSQRYCECNADIVGR--LRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGI 931
            |||.|:.||.|||.   |:  ..|:||.:|||::||||.||||:|.:|  .:|..|.:||..|||
Human   800 LMEKFAARYLECNQ---GQTLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGI 859

  Fly   932 DDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCY 988
            :|..|:.::.|..||:.:...:..     :.:..::.......|.|:|...:|.:.|
Human   860 NDSKDLPEEYLSAIYNEIAGKKIS-----MKETKELTIPTKSSKQNVASEKQRRLLY 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sizNP_730594.1 Sec7 766..954 CDD:460178 83/199 (42%)
PH_IQSEC 981..1108 CDD:270128 2/8 (25%)
ARFGEF1NP_001400123.1 DCB, DCB:DCB domain and DCB:HUS domain interaction 2..224
PLN03076 15..1766 CDD:215560 174/707 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..248
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 267..302 8/18 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..413 15/40 (38%)
HUS, DCB:HUS domain interaction 557..577 2/19 (11%)
Nuclear localization signal (NLS) 711..715 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1562
Blue background indicates that the domain is not in the aligned region.

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