DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and gbf1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031761940.1	Gene:	gbf1 / 100380093	XenbaseID:	XB-GENE-1012128	Length:	1890	Species:	Xenopus tropicalis

Alignment Length:	1089	Identity:	223/1089 - (20%)
Similarity:	384/1089 - (35%)	Gaps:	290/1089 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 DVLKRTRAQSAYELSQDLLEKQIELLERKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAE 366
            ::|:::...:..::.|.|..:..:..|      .|::...|..:.....::.|...:....:|..
Frog   175 ELLRKSAEHTLVDMVQLLFSRLPQFKE------EAKSYIGTNMKKISPCLLCKMELNSGEQSKNL 233

  Fly   367 KRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPR-VT--IMAGPAGAA 428
            .:|.|.::..:..|.:...|.|.||.:             ::|.:..:||| ||  :.|....:.
Frog   234 NQLERVLLFKSLKLKMRAGGMSDSSKW-------------KKQKKSPRQPRHVTKAMAAAEPSSQ 285

  Fly   429 SPGLSRTPPTRSLSMRERRQLDCS------PIPRSQSGASPASISSSTVS----TSALASHPHVN 483
            .|.::.|..|.:|: .|...:|.|      ||....|.|:.|.:|.:|.|    :|...|...::
Frog   286 QPVVNGTTITTNLT-GEVPFIDASSPDANFPISGVSSEATSAVVSPTTDSGVDMSSQATSKEDLS 349

  Fly   484 LLHAAEPHYYNAQALPQGA----------------------AYYTSYHGSPHDL-SYASSADTSL 525
            .|..|.|   :..|:.|..                      .|..|....|..| ...|.||.|.
Frog   350 ELDPASP---SLSAIQQSGDICLSEQQNQDDDKIEDLMERHTYSASVESIPEVLDDNVSLADQSD 411

  Fly   526 NASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVP---- 586
            :||..:..              |:.|:|...|.:....|:.             .||..:|
Frog   412 SASVHDMD--------------YVNPRGVRFTQSSQKEGTV-------------LVPYGLPCIRE 449

  Fly   587 -------------KRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCK----------------- 621
                         :..|.:......||:.:..::.|..:.:...||.|
Frog   450 LFRFLISLTNPHDRHNSEVMIHMGLQLITVALESAPIENYVSLLGLVKDELCRHLFQLLSIERLN 514

  Fly   622 -----------------------------------TAENGSL----------TSVQSSGSDSSVT 641
                                               |.||..:          ..||.....|.||
Frog   515 LYAASLRACFLLFEGMREHLKFQLEMYIKKLMDIITVENPKMPYEMKEMALEAIVQLWRIPSFVT 579

  Fly   642 SAERNLNSDLGSDRSNSPHTWKRGTALN----SSQQFSTH------------SADS--------- 681
              |..:|.|.....||......:..:.|    |.|.::||            |.:|
Frog   580 --ELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLEALLTVIDSTESHCQAKNLSN 642

  Fly   682 -------AGAVSGG---GVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSH-TSAAQYEQ 735
                   .|..||.   |...:|....::.:::....:|...|..||...|.::.. |...|..:
Frog   643 VSQDKKETGKPSGDLSEGTKDSGNLNEHSIEVKPFTVSAENNGSKPPTSGHLMADKMTLGVQETE 707

  Fly   736 HEQQQHEQQQLQAAAAAAGVAQNYKMSETI--RKRQYRVGLNLFNKKPEKGITYLIRRGFLENTP 798
            :.....|::.|:.....:.:..|.:....|  :|:....|...||:||:||:.:|..:..|. ||
Frog   708 YSTDGGEKKTLKKPQRFSCLLPNVQELNDIKTKKKLLITGTEQFNQKPKKGVQFLQEKDLLA-TP 771

  Fly   799 QG---VARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMP 860
            ..   ||::|.....|.::||||::.:.:   |:.:|..|.......|.:||.|||.:...||:|
Frog   772 MDNAEVAQWLRENPRLDKKMIGEFVSDRK---NLDLLESFVGTFHFQGLRVDEALRLYLEAFRLP 833

  Fly   861 GEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPER-RMRVEDF 924
            |||..|:||:|.|::.:.:.|..   ....||..|.||:|:||||||.|..|::.:. .|.:|:|
Frog   834 GEAPVIQRLLEAFTEHWRKSNGT---PFAHSDACFALAYAVIMLNTDQHNHNVRKQNVPMTLEEF 895

  Fly   925 IKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKP---NLALPHRRLV 986
            .|||:|::...|.|:|||..||..:|::|.         ||..:.|.:.|:.   |:.| ||...
Frog   896 RKNLKGVNGGKDFDQDMLEDIYHAIKNEEI---------VMPEEQTGLVKENYFWNVLL-HRGAT 950

  Fly   987 CYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLD-- 1049
            .......:.       ||.:..::|        |..:.....:::|.|..|..     .|::.
Frog   951 PEGMFLHVD-------PGSYDHDLF--------TMTWGPTIAALSYVFDKSMD-----ETIIQKA 995

  Fly  1050 MPNYPFCIQLS-----QKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQK 1109
            :..:..|..:|     ..|...::|:.        |||.....|::..:..:....::|:
Frog   996 ISGFRKCAMISAHYGLSDVFDNLIISL--------CKFTTLSSEAVENLPTVFGSNLKAQ----- 1047

  Fly  1110 SARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQF- 1173
                            :|...|....::.| ....|...|..|:..||.|:.|....:...|.|
Frog  1048 ----------------IAAKTVFHLSHRHG-DILREGWKNIMDSMLQLFRAELLPKAMVEVEDFV 1095

  Fly  1174 ---GNEKPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAIAAAANAAA 1219
               |....||.....:......:||.|..|.|.:.:::....:..|..|
Frog  1096 DPNGKISLQREEIPANRGESTVLSFVSWLTLSGTEQSSLRGPSTENQEA 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	70/191 (37%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	19/133 (14%)
gbf1	XP_031761940.1	COG5307	442..>1191	CDD:227623	162/772 (21%)
		Sec7	740..925	CDD:396096	70/191 (37%)
		PHA03247	<1753..1886	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910