DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment siz and arfgef1

DIOPT Version :9

Sequence 1:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_009295669.1	Gene:	arfgef1 / 100329953	ZFINID:	ZDB-GENE-030131-108	Length:	1870	Species:	Danio rerio

Alignment Length:	854	Identity:	193/854 - (22%)
Similarity:	309/854 - (36%)	Gaps:	207/854 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 QIQQYPTCHQQQQQQHLQ-QQQHLHQTGAGHYMQVTATGGGQYHHHHMLHGHGHHAHHHGGAVVI 261
            |:|:.....:::.:||.. .||.....|..|    |.|.|      ..|...|:....|.|..|.
Zfish   231 QLQEAKQMERERHRQHSPVSQQEPESPGQRH----TETPG------KTLPAEGNGGPGHQGGKVE 285

  Fly   262 AGSG--VGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGGDVLKRTRAQSAYELSQDLLEKQI 324
            .||.  ......:|:.....:::|.:..|.....:::..:..:..:....|:..|.:|:::|
Zfish   286 QGSPPYESPEPENGSDFCPAENEQTEADQATAAAQSAAEHATEASEEDERQNYEEKAQEIVE--- 347

  Fly   325 ELLERKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAEK-RLSRRMVVTASSLGLAEEGAS 388
            .:|......|...|..||..:|...             .:||. .:|...:.....||...|...
Zfish   348 SVLLEVVNTVATGNMYVTEMKASHE-------------GEAESAEVSPNSLEEEGGLGSDNENVH 399

  Fly   389 SSSAYGSATESQLT----EQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTP--PTRSLSMRERR 447
            ::...|:...:..|    :.:....:...|:...|....|....|..|.:..  ..|||.....:
Zfish   400 ANGIPGTPISASFTPSLPDDRLSVSSNDTQESVATSGQAPGAKFSHILQKDAFLVFRSLCKLSMK 464

  Fly   448 QL-DCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGS 511
            .| |..|.|:|.      .:.|..:|...|.|     :|..|.|.:...:........|.....|
Zfish   465 PLSDGPPDPKSH------ELRSKVLSLQLLLS-----ILQNAGPIFKTNEMFINAIKQYLCVALS 518

  Fly   512 PHDLSYASSA-DTSLNASWVNTSGHSPHTP-----YYSAAQIYMRPKGGST---------TPTPS 561
            .:.:|..... :.||:......|....|..     ::....:|:.....|:         |.|..
Zfish   519 KNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSYDHKWMVIQTLTRI 583

  Fly   562 CS-----------------------------GSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQ 597
            |:                             .....|.||...|:
Zfish   584 CADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGGHELGT-------------------- 628

  Fly   598 TQLLLLQRQTPPPPSLLRTNGL-C-----KTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRS 656
                     ||.....||..|| |     |.....|.....:..|.:|:..|.:...|:..|:.|
Zfish   629 ---------TPLQELTLRKKGLECLVSILKCMVEWSKDQYVNPNSQTSLGRAGQEKPSEQESNES 684

  Fly   657 NSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADD 721
            ..|.|..|..::|        |.||.         .:.|.|.|:.||
Zfish   685 KHPETINRYGSIN--------SLDST---------ASSGIGSYSTQM------------------ 714

  Fly   722 HAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGIT 786
               |...:..|:|..:||:...:|                           |::||||||::||.
Zfish   715 ---SGTDNPEQFEVLKQQKEIIEQ---------------------------GIDLFNKKPKRGIQ 749

  Fly   787 YLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALR 851
            ||..:|.|..||:.:|:||...:.|....:||:||: .::.|..|:..:..::|..|:....|||
Zfish   750 YLQEQGMLGTTPEDIAQFLHQEERLDSIQVGEFLGD-NDRINKEVMYAYVDQMDFQGKDFVPALR 813

  Fly   852 KFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGR--LRSSDTIFVLAFAIIMLNTDLHTPNLK 914
            .|...||:|||||||:||||.|:.||.|||.   |:  ..|:||.:|||::||||.||||:|.:|
Zfish   814 MFLEGFRLPGEAQKIDRLMEKFAARYLECNQ---GQTLFASADTAYVLAYSIIMLTTDLHSPQVK 875

  Fly   915 PERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLA 979
              .:|..|.:||..|||:|..|:.::.|..|||.:...:       ::.....:.|:...|.::|
Zfish   876 --NKMTKEQYIKMNRGINDSKDLPEEYLSAIYDEIAGKK-------ISMKETKELTLKSNKQSVA 931

  Fly   980 LPHRRLVCY 988
            ...:|.:.|
Zfish   932 SEKQRRLLY 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	80/189 (42%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	2/8 (25%)
arfgef1	XP_009295669.1	PLN03076	15..1830	CDD:215560	193/854 (23%)
		DCB	29..210	CDD:292830
		Sec7_N	447..601	CDD:289549	28/164 (17%)
		Sec7	729..913	CDD:279680	82/223 (37%)
		DUF1981	1246..1327	CDD:286414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740