Protein Alignment siz and iqsec1

DIOPT Version :9

• Sequence 1: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001107304.1
• Gene: iqsec1 / 100135093
• XenbaseID: XB-GENE-997008
• Length: 1001
• Species: Xenopus tropicalis
• Alignment Length: 1089
• Identity: 375/1089 - (34%)
• Similarity: 511/1089 - (46%)
• Gaps: 273/1089 - (25%)

  Fly   326 LLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASS 389
            :||||||| :.:|:||.|||.|||.|.|.|.|..:.: :.:|.|:|||:|::...:..:.||...
 Frog     1 MLERKYGGRLVSRHAARTIQTAFRQYQMNKNFERLRS-SMSENRMSRRIVLSNMRMQFSFEGPEK 64

  Fly   390 -SSAYGSATESQLT----EQQQQQQAQQQQQPRVTIMAGPAGA---------------------- 427
             .|:|....:..|:    :..:..|::...:...|.|..||.:
 Frog    65 VHSSYFEGKQVSLSNDGPKMGRMVQSECGDRGEQTAMKSPAASSDFADAITELEDAFSRQVKSLA 129

  Fly   428 -------------ASPGLSRTPPTRSLSMR-------------ERRQLD---------------- 450
                         |..|.| ..|.|...|.             :.|:||
 Frog   130 ESIDDALNCRSLHADEGQS-ADPIRGREMERSSSGQLKAAHNLDHRKLDEMTASYSDVTLYIDEE 193

  Fly   451 --CSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPH 513
              ..|:|.||||....| :.|.:...::.|..:.::.|..:....:           ||...:|
 Frog   194 ELSPPLPLSQSGDRTPS-TESELRLRSMNSQEYWSMTHKEDKLDTD-----------TSCRSTP- 245

  Fly   514 DLSYASSADTSLNASWVNTSGHSP----HTPYYSAAQIYMRPKGGST-------TPTPSCSGSTG 567
                  |.|...:.|.::   |.|    ..|..|:..:..|.:.||.       ...|:..||
 Frog   246 ------SLDCQDHRSRID---HLPLLTIEPPSDSSVDLSDRSERGSVKRQNVYERGIPNQQGS-- 299

  Fly   568 SGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQ 632
                          |..:|...:.|..:::.|    .|..|.|..       .:...||::....
 Frog   300 --------------PKHIPHIPTKILPREEEQ----PRHRPRPID-------AQLIINGTINRQS 339

  Fly   633 SSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAG 697
            .|.||          .||..:|..||  |......:|.|.:
 Frog   340 KSESD----------YSDGDNDSINS--TSNSNDTINCSSE------------------------ 368

  Fly   698 VYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMS 762
                                       ||..|..:....:|..|::.:....:.|..       :
 Frog   369 ---------------------------SSRDSLREQTLSKQTYHKETRNSWDSPAFS-------N 399

  Fly   763 ETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQF 827
            :.||||.||:|||||||||||||.|||.|||:.:||.|||.||:.|||||||||||:|||.|.||
 Frog   400 DVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQF 464

  Fly   828 NMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSD 892
            |..||.|...|:|.|..::|.|||||||:.|:.|||||:|||:|.||||||.||..:|.:.|:.|
 Frog   465 NRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 529

  Fly   893 TIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPG 957
            |||:||||||:||||:::||:||||:|::|||:|||||:||..||.::.|:|||:|:...|.|..
 Frog   530 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLVGIYERIHKRELKTN 594

  Fly   958 SDHVTQVMKVQATIVGKKP----------NLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFL 1012
            .|||:||.||:..||||||          .|:||||||||||||:|:||.||.::.|:||||:||
 Frog   595 EDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFL 659

  Fly  1013 FNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDG---KILITFNAR 1074
            ||||||:||||.|||.||||:||.||.|.|..|.|.:..|||..|:||..:.|   |:||.|||.
 Frog   660 FNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLYENHNYPNAIRLSSAIPGADVKVLINFNAP 724

  Fly  1075 NEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQG 1139
            |..||.||.:||:|||:|:.|||..|||:|||:||               ||    |.|...|..
 Frog   725 NTQDRKKFTDDLRESIAEVQEMEKYRIESELEKQK---------------GV----VRPSMSQSS 770

  Fly  1140 S--QASGEQAPNSA--DNS----QQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQ 1196
            |  :.||..|.|.|  |:|    :.|||||||:||.|:.|.   .|..||.|.|||||.|..|..
 Frog   771 SLKKDSGNGALNRACLDDSYATGEGLKRSALSSSLRDLSEA---GKRGRRSSAGSLDSNMEGSII 832

  Fly  1197 S---------TTTSSASRENAAAIAAAANAAAAAKMRFNMPPTAAIATPSNVYAAPGMQAYTHAN 1252
            |         :|....||::....:::...:.....| ..||:   ::.|..:.|.|
 Frog   833 SSPHIRRRTPSTRECPSRQSMPNSSSSLLGSLFGTKR-GKPPS---SSSSQGHLASG-------- 885

  Fly  1253 FVQQSQAAYMLQQQQMLQQQAQMQAQAQAQAQAQAQAQAQAQAQAQAQP 1301
               .||...::..|:  ....::....:.|.|||..||.......|..|
 Frog   886 ---ASQHPTLISHQR--HSTGELVGPPEGQTQAQVHAQHSQYYHMQQNP 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
siz	NP_730594.1	Sec7	766..954	CDD:279680	121/187 (65%)
		PH_IQSEC	981..1108	CDD:270128	81/129 (63%)
iqsec1	NP_001107304.1	Sec7	403..591	CDD:279680	121/187 (65%)
		PH_IQSEC	628..758	CDD:270128	81/129 (63%)
		Hep_59	745..>799	CDD:284467	26/72 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1930
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1134
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360558at33208
OrthoFinder	1	1.000	-	-		FOG0002052
OrthoInspector	1	1.000	-	-		otm48656
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X920
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060