DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdss2 and PDSS2

DIOPT Version :9

Sequence 1:	NP_001287138.1	Gene:	Pdss2 / 40323	FlyBaseID:	FBgn0037044	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	XP_011534258.1	Gene:	PDSS2 / 57107	HGNCID:	23041	Length:	465	Species:	Homo sapiens

Alignment Length:	488	Identity:	162/488 - (33%)
Similarity:	240/488 - (49%)	Gaps:	126/488 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 APALQTFTS-QRWTSTTTTSGKHASPQVTTPPPRHDWNRAVSEAERIVGYPTSFLSLRWLLSDEI 95
            :|:|.|.:| ..|...::.|..|             ||:.|||||:||||||||:|||.|||||:
Human    26 SPSLDTISSVGSWRGRSSKSPAH-------------WNQVVSEAEKIVGYPTSFMSLRCLLSDEL 77

  Fly    96 ANVALHLRKLVGSAHPLMKTAKHLLYNGKNTMQAWGLIVLLVSKAAGHAPSVPDV---EQDKSAG 157
            :|:|:.:|||||:.|||:.||:.|:::..|::|..||:|||:|||||  ||..:.   ..|..:|
Human    78 SNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAG--PSSVNTSCQNYDMVSG 140

  Fly   158 VLHSQRALAEVTEMIRISHLVHNSVVN---LQSSTQAGQDVDTYDDMSFGNKIGLLTGDYLLGHS 219
            :...||:|||:||:|.|:.|||..:||   ||||.      ....||.|||||.:|:||:||.::
Human   141 IYSCQRSLAEITELIHIALLVHRGIVNLNELQSSD------GPLKDMQFGNKIAILSGDFLLANA 199

  Fly   220 SAELANLRNQEVVELISSAVRDFSESEFIGERDEQNNPLPYKPGTFQRPSLSVGVDFNEHDVMTP 284
            ...||.|:|.:||||::||:.|                            |..|| ::|:.....
Human   200 CNGLALLQNTKVVELLASALMD----------------------------LVQGV-YHENSTSKE 235

  Fly   285 MPIAQVLGNPEEEWECRNILNAGSLLGKSCQASLKLAGQSEELQRHAYRFGKHLALAWQACLDAE 349
            ..|...:|  ...|:.:..|:.|:||.|||||:::||....|:|..|:::|||:|::.:...|.:
Human   236 SYITDDIG--ISTWKEQTFLSHGALLAKSCQAAMELAKHDAEVQNMAFQYGKHMAMSHKINSDVQ 298

  Fly   350 PFQCPQLPLDVTFSLVSAPVLFHLEH---------------------------------DPGMYS 381
            ||...:....:||:|.||||:.|.|.                                 |....:
Human   299 PFIKEKTSDSMTFNLNSAPVVLHQEFLGRDLWIKQIGEAQEKGRLDYAKERGLAVTQTGDAFFMT 363

  Fly   382 Q-----------LEAGKQ-----------------------SVDNIDYDKIHKAILAGPALAKTK 412
            |           |:.|:.                       |..|...:.:.:.|.||..:....
Human   364 QRMPLGFLITEALDNGRDFHWKMAKRKIWCTNKSTPGPSNGSATNSMQNLLRERIKAGKGVTSAI 428

  Fly   413 ELQRKHTAAALAVLQHFPATDARQALENIILAM 445
            :|.|.|...||..|:.||.::||.|||||:.|:
Human   429 DLCRYHGNKALEALESFPPSEARSALENIVFAV 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdss2	NP_001287138.1	Isoprenoid_Biosyn_C1	86..441	CDD:294142	137/427 (32%)
PDSS2	XP_011534258.1	Isoprenoid_Biosyn_C1	68..465	CDD:294142	140/433 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159357
Domainoid	1	1.000	113	1.000	Domainoid score	I6161
eggNOG	1	0.900	-	-		E1_COG0142
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56885
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3293
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49922
OrthoDB	1	1.010	-	-		D304684at33208
OrthoFinder	1	1.000	-	-		FOG0008031
OrthoInspector	1	1.000	-	-		oto89808
orthoMCL	1	0.900	-	-		OOG6_108493
Panther	1	1.100	-	-	LDO	PTHR12001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R321
SonicParanoid	1	1.000	-	-		X5986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800