DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12983 and DNAI7

DIOPT Version :9

Sequence 1:	NP_001137992.1	Gene:	CG12983 / 40319	FlyBaseID:	FBgn0037040	Length:	1104	Species:	Drosophila melanogaster
Sequence 2:	XP_005253463.1	Gene:	DNAI7 / 55259	HGNCID:	29599	Length:	780	Species:	Homo sapiens

Alignment Length:	813	Identity:	145/813 - (17%)
Similarity:	278/813 - (34%)	Gaps:	226/813 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 KAKHASYEKFNITLHEDGRVLRKSLNILDESSTEECSMQPSKLDIGTDIMRDTEVGEASKIPLH- 487
            |||.:..:|..:|..|..::|::.    :|...:|  .:.::|....:.|...|:....|...|
Human    62 KAKKSGSKKKKVTKAERLKLLQEE----EERRLKE--EEEARLKYEKEEMERLEIQRIEKEKWHR 120

  Fly   488 LEPDEL--------PYYFLTFKVPNH---------LCLWGEPIVCQFFESEIEETPSKAKAEELD 535
            ||..:|        ..|.|....|..         |..|...|.|       :.:|..:.|:|::
Human   121 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQC-------DGSPDPSVAQEMN 178

  Fly   536 KKLDKKKKPVRKSSRKENESVLRVPTTSGSVSMSEEK--------PPQSNRPTYHQPARENSVNI 592
            ..:...|:       |.||:...|...|..|....||        ||..        .::.::..
Human   179 TFISLWKE-------KTNETFEEVIEKSKVVLNLIEKLKFILLETPPCD--------LQDKNIIQ 228

  Fly   593 YRPSALTIVR----QSGMETEQI-------------QYKKTFKN--------SNLVKEPISKRNL 632
            |:.|.|.:..    :.|:.||.:             ..:|..|:        :||.|.| ..|::
Human   229 YQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNP-RHRSV 292

  Fly   633 SLLQDQC---LPRIIS----SLRFPRDFQDDKMEAQAMKKIPV-TQLYKRQLTESVGS--TQIEK 687
            ...:.|.   :|||::    ::|......|   ...|:..:.. ::.|...:||.|..  ..:||
Human   293 RFSETQIGFEIPRILATSDIAVRLLHTHYD---HVSALHPVSTPSKEYTSAVTELVKDDVKNVEK 354

  Fly   688 -FSFNYEDQSNPERLYPKFPVTEDLRVETDRTD------SSKEEGTMLGLLRTLEGIKDKYLDAP 745
             .|...|::|..:.........|:::||.::.|      |::||...:...|.::.:.:....|.
Human   355 AISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ 419

  Fly   746 KRIVEQTT-------------------------------------------HAVRMSRKAYSDPI 767
            ..:||.::                                           ..::...:.|:.|.
Human   420 LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPP 484

  Fly   768 PTTRS-RRQSYFGRRSVRQLDSSIMSIARPVDIEYELSETSDTGEQMIKSRKDSRLPSTILSQSA 831
            .||.. ..::.|                .|:::..|:.|.....|..:..|.|:
Human   485 ETTEEFETENAF----------------PPIEVTLEVHENVIFFEDPVVVRWDA----------- 522

  Fly   832 EPRNAAHWTTEFILESSFNKESKVVIVKTDRLGHFGFAYRRYAHFPFRHWELEKNEQNHDEIILT 896
               ...||.|:.|...|:..:.::|....|..|........:.:.|::.|||...:.|  :::||
Human   523 ---EGKHWRTDGISNVSYKPKERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVN--KVLLT 582

  Fly   897 LDTYHVRVVFFISKDGIRCHAIDIPKEYVHRPFKYIDIDK-----PISDFVELRKRLQDMNLNVF 956
            :.|....:...|.::.....:|.:..:      |:|.|.:     ||...:.|:    :..||:|
Human   583 VTTVFTEIQIQIKENLCMLSSIKLKDK------KHISILEGTWMTPIPFIIALK----EAGLNIF 637

  Fly   957 AELDACFYIDQGYFSQKHLAAELHIYDAIAVHGKLMKFSRSQWNRLAKDRDLVL---------CL 1012
            ....:.||:   ..:.|....|:..|..:|:......|..|:||.|.....:|.         |.
Human   638 PTRHSHFYV---IINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACT 699

  Fly  1013 QNTR---DIHDGSEV-TVRVTPEVSTFVDVSELCSDDTKVIKLNYKSTWRNMGTYSDLHQLINSM 1073
            :|..   .:..|... .:::..|...|   ||...::|:.              :|.|:.::...
Human   700 ENPNWALLMFSGDRAQRLKIKEESEAF---SEALKEETEF--------------HSTLYHMVKDF 747

  Fly  1074 YPQATDMRNRDANQMYY--IRQLLQEIRPLSFS 1104
            ..:....:.|.:|..:.  :..:|...|.||:|
Human   748 ASEEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12983	NP_001137992.1	Casc1	253..515	CDD:289161	23/108 (21%)
CG12983	NP_001137992.1	Casc1	839..1054	CDD:289161	46/232 (20%)
DNAI7	XP_005253463.1	Casc1_N	98..288	CDD:292549	41/212 (19%)
		Casc1	303..518	CDD:289161	35/233 (15%)
		Casc1	542..>685	CDD:289161	33/157 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D526857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR20929
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3892
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	5.000