Protein Alignment CG12983 and Casc1

DIOPT Version :9

• Sequence 1: NP_001137992.1
• Gene: CG12983 / 40319
• FlyBaseID: FBgn0037040
• Length: 1104
• Species: Drosophila melanogaster
• Sequence 2: NP_796196.3
• Gene: Casc1 / 320662
• MGIID: 2444480
• Length: 730
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 177/1147 - (15%)
• Similarity: 338/1147 - (29%)
• Gaps: 503/1147 - (43%)

  Fly     3 KRKNQDAVSIKPAVELLSEEEWMARRNIYMQRLADLKTSVAFIDDAVEEYKELQKQKLRN-DKWN 66
            :::.|:.:.|    :.:..|:|.......::|.:.....:|.::....| .|.||:::|. .:|.
Mouse    42 EKEEQERLEI----QRIEREKWSLLEKKDLERRSQELEELALLEGCFPE-AEKQKREIRALAQWK 101

  Fly    67 SYLACDGLPNPSRPAEIRKFIFQLNFMEQESCANEISWVLSVDECSVLSQAPDRCDRTRKIMEKS 131
            .|..|||.|:|....|:..||   :..|:|.                 :||      ..::||||
Mouse   102 HYTECDGSPDPWVAQEMNTFI---SLWEEEK-----------------NQA------FEQVMEKS 140

  Fly   132 RPNVGQLYDETVQRILATIERVQRVLRNDDELVHLPTFQVRELDKIPNELYGEIESFFDKLTYRV 196
            :            .:|:.||:|:.:      |:..||:::.....:.::  |.|....:.|:.::
Mouse   141 K------------LVLSLIEKVKLI------LLETPTYELDHRTVLQHQ--GSILRLQELLSLKI 185

  Fly   197 VSSPDALMM-----------NKDSILSCYCYKCSNFDLEIW-GLQDVP----IRFNYLKLPVMCS 245
            ..:.:.|:.           |.:.|:     |..|..|.:| .|:..|    :||:..:
Mouse   186 NVATELLLRQASNLADLDTGNMEKII-----KDENVTLYVWANLKKNPRHRSVRFSETQ------ 239

  Fly   246 DLNCVGVTIQLPLSVLCDNLTLRCVRTFFDPLSHLAKSFELVIDSSVIPNCGLVDIADSVMSEWM 310
                  :..::|..:...|:.||.:.|.:|   |:...|.:.:........|    |:.|..|..
Mouse   240 ------IGFEIPRILATSNVALRLLHTRYD---HITPLFPIAVTEQNQNPVG----AEQVNVEES 291

  Fly   311 TQMDIQEDLVVKMETEMRAYNEAIAFIAQAEAKEKRKSQKKKIAIPKPPKMPQELPAGMFPDPRK 375
            |:..:.|:   |:.||.:|.||                       .:.||..||
Mouse   292 TEKAMTEE---KLFTEEKAANE-----------------------DEQPKAEQE----------- 319

  Fly   376 IFLEHEKRDCTDFFNRYFHPGNINLLPSEVNLRRFIILGGIVSLVFVGKAKHASYEKFNITLHED 440
                                ..:||:..|                       ..||....|
Mouse   320 --------------------RELNLVQEE-----------------------NKYEAIENT---- 337

  Fly   441 GRVLRKSLNILDESSTEECSMQPSKLDIGTDIMRDTEVGEASKIPLHLEPDELPYYFLTFKVPNH 505
              ||:::      |.:|....|.::|::...::  :|...|:::.|.....|||.....:||.
Mouse   338 --VLQRT------SDSEGEDSQTTQLELEMKLL--SEAVLAAQLCLVENVVELPEASQAYKVD-- 390

  Fly   506 LCLWGEPIVCQFFESEIEETPSKAKAEELDKKLDKKKKPVRKSSRKENESVLRVPTTSGSVSMSE 570
                    :|.|                                           :|.|.|...:
Mouse   391 --------LCHF-------------------------------------------STLGGVYHLD 404

  Fly   571 --EKPPQSNRPTYHQPARENSVNIYRPSALTIVRQSGMETEQIQYKKTFKNSNLVKEPISKRNLS 633
              |.|||. :|.             :...|..:.|.|::
Mouse   405 VLELPPQC-KPV-------------KGWVLVEILQEGLQ-------------------------- 429

  Fly   634 LLQDQCLPRIISSLRFPRDFQDDKMEAQAMKKIPVTQLYKRQLTESVGSTQIEKFSFNYEDQSNP 698
                          ||                     :|....||                :.:|
Mouse   430 --------------RF---------------------IYPPDTTE----------------EPDP 443

  Fly   699 ERLYPKFPVTEDLRVETDRTDSSKEEGTMLGLLRTLEGIKDKYLDAPKRIVEQTTHAVRMSRKAY 763
            :..:|...||                                 |:..|.::
Mouse   444 DVTFPPIEVT---------------------------------LEIHKSVI-------------- 461

  Fly   764 SDPIPTTRSRRQSYFGRRSVRQLDSSIMSIARPVDIEYELSETSDTGEQMIKSRKDSRLPSTILS 828
                         :|.|..|.:.|:
Mouse   462 -------------FFERPRVVRWDN---------------------------------------- 473

  Fly   829 QSAEPRNAAHWTTEFILESSFNKESKVVIVKTDRLGHFGFAYRRYAHFPFRHWELEKNEQNHDEI 893
                  ....|.::.|....:|:|.:::....|.||........:.:.|::.||:.....|  ::
Mouse   474 ------EGKFWRSDGISSVYYNREDRLLTFSMDTLGPVTLIQDAHVNMPYQSWEMSPCGMN--KV 530

  Fly   894 ILTLDTYHVRVVFFISKD------------GIRCHAIDIPKEYVHRPFKYIDIDKPISDFVELRK 946
            :|.:.|..:.:..:|.::            |:..|.    |.....|..:|             .
Mouse   531 LLIVKTVFMELQIYIKENLCMLASVKLRGKGLEFHL----KGKWMAPIPFI-------------L 578

  Fly   947 RLQDMNLNVFAELDACFYIDQGYFSQKHLAAELHIYDAIAVHGKLMKFSRSQWNRLAKDRDLVLC 1011
            .|::..||:|..:.:.||:   ..:.|....||..|..:|:......|..|:||        ::|
Mouse   579 ALKEAGLNIFPAVYSHFYV---VINNKVPQVELKAYRQMALLSSAFSFGWSKWN--------MVC 632

  Fly  1012 LQNTRDIHDGSEVTVRVTPEVSTFVD-----VSELCSDDTKVIKL-----NYKSTWRNMGT--YS 1064
                    :.:.|.:||..::|...:     :.....|..:::|:     .:....|. ||  :|
Mouse   633 --------NSTRVVIRVREQLSEETEHHTWSLLMFSGDRAQMLKMQEENDKFSEALRE-GTEFHS 688

  Fly  1065 DLHQLINSMYPQATDMRNRDANQMYY--IRQLLQEIRPLSFS 1104
            .|:.::..........|.|.:|..:.  :..:|..||.||:|
Mouse   689 TLYHMMKDFASPVAMERVRHSNCQFIDSVCYMLLSIRVLSYS 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12983	NP_001137992.1	Casc1	253..515	CDD:289161	44/261 (17%)
		Casc1	839..1054	CDD:289161	41/236 (17%)
Casc1	NP_796196.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Casc1_N	39..229	CDD:292549	47/242 (19%)
		Casc1	244..469	CDD:289161	70/529 (13%)
		Casc1	483..651	CDD:289161	38/205 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833364
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D526857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR20929
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3892
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	5.000