Protein Alignment CG12983 and CG33286

DIOPT Version :10

• Sequence 1: NP_001137992.1
• Gene: CG12983 / 40319
• FlyBaseID: FBgn0037040
• Length: 1104
• Species: Drosophila melanogaster
• Sequence 2: NP_001097653.1
• Gene: CG33286 / 2768984
• FlyBaseID: FBgn0053286
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1149
• Identity: 418/1149 - (36%)
• Similarity: 639/1149 - (55%)
• Gaps: 132/1149 - (11%)

  Fly     1 MVKRKNQDAVSIKPAVE------LLSEEEWMARRNIYMQRLADLKTSVAFIDDAVEEYKELQKQK 59
            |||||:..|.  ||..|      |:||.|.|.|...||.||.|...|...:..|..::...:..:
  Fly     1 MVKRKSTAAA--KPVAEPILRYPLISENEVMDREARYMSRLNDFTVSAELVKGAQRDFYNQEVDR 63

  Fly    60 LRNDKWNSYLACDGLPNPSRPAEIRKFIFQLNFMEQESCANEISWVLSVDECSVLSQAPDRCDRT 124
            :..:.|..:|.|||||.|..|.|:|.|:.::.|.::....|.:.|.|||||.|:|:|...|.|:|
  Fly    64 MFREHWEHHLRCDGLPRPYLPVEVRTFMSKIRFYDEIETNNSMDWTLSVDERSILTQNIFRVDKT 128

  Fly   125 RKIMEKSRPNVGQLYDETVQRILATIERVQRVLRNDDELVHLPTFQVRELDKIPNELYGEIESFF 189
            |::|..::.|.|:.||..||..|..::::..:|.|:.|:|.:...:.:::.::..|:..||...|
  Fly   129 RRMMMVNKDNPGEHYDHNVQMCLNALKQMDAMLDNEAEMVRMSDKRQKDVIEVYTEVEAEIGDLF 193

  Fly   190 DKLTYRVVSSPDALMMNKDSILSCYCYKCSNFDLEIWGLQDVPIRFNYLKLPVMCSDLNCVGVTI 254
            |:|||||:|..||.|.:||..::.:.|.|:.:.|::|||::|||.|:.|:||||.::.:...|.:
  Fly   194 DRLTYRVLSMQDAYMESKDGRVAVWSYTCNPWRLDLWGLRNVPIIFDQLELPVMLAEFSATSVEV 258

  Fly   255 QLPLSVLCDNLTLRCVRTFFDPLSHLAKSFELVIDSSV-IPNCGLVDIADSVMSEWMTQMDIQED 318
            |:|.|||.|.:|:|.:...||.:|..|||||:.:.:|: .||.|:|||.:||::||..|::|||:
  Fly   259 QIPKSVLKDCVTIRSLHMDFDNISQNAKSFEIAVKASLNYPNAGIVDIENSVVNEWHMQLEIQEE 323

  Fly   319 LVVKMETEMRAYNEAIAFIAQ------AEAKEKRKSQKKKIAIPKPPKMPQELPAGMFPDPRKIF 377
            .:..|.|..|.|.:.:..||:      ..||:....:..||.|||.||.|..:|.|||||..:.|
  Fly   324 TLNLMLTRRREYEDMMELIAEKTEQAAKAAKQTDPDKMVKITIPKAPKEPPYVPTGMFPDIYEDF 388

  Fly   378 LEHEKRDCTDFFNRYFHPGNINLLPSEVNLRRFIILGGIVSLVFVGKAKHASYEKFNITLHEDGR 442
            |..|:...:.:.:...||.::::.|.|:|||.:|:||||.|::|:.:.....:|:|||.||||||
  Fly   389 LRIEESQYSGYLDEVCHPRHLDMQPFEINLRDYIMLGGIYSIMFIRRPDQTQFEQFNIVLHEDGR 453

  Fly   443 VLRKSLNILDESSTEECSMQPSKLDIGTDIMRDTEVGEASK-----IPLHLEPDELPYYFLTFKV 502
            |    ::||.|          .|.||..:.:|.:.:|..::     ..:.||.|||||:.:|.:|
  Fly   454 V----VHILTE----------MKADIPVEAVRKSNIGRKTRETYRGTKIKLEDDELPYFIVTLQV 504

  Fly   503 PNHLCLWGEPIVCQFFESEIEETPSKAKAEELDKKLDKKKKPVRKSSRKENESVLRVPTTSGSVS 567
            ...||.|.||:||.|. :|.:..|:       |.|.:....|..:|..:.:|...|.....||..
  Fly   505 AADLCKWSEPVVCHFI-TEKDFIPT-------DYKRESYWVPTMQSVIRHSEYAGRSMLNLGSQI 561

  Fly   568 MSEEKPPQSNRPTYHQPARENSVNIYRPSALTIVRQS--------GMETEQIQYKKTFKNSNLVK 624
            ..:                  |.||:|||..:.:|||        |:..|..:.:|
  Fly   562 SGD------------------SANIFRPSLRSFLRQSKVGAAPKPGVPIEDFKLEK--------- 599

  Fly   625 EPISKRNLSLLQDQCLPRIISSLRFPRDFQDDKMEAQAMKKIPVTQLYKRQLTESVGSTQIEKFS 689
             .:|...:..|:..||||||||.:||.||:|:|.|  .:::.| ..|.||...|.| .||::...
  Fly   600 -KLSHLEIRTLEKYCLPRIISSFKFPVDFRDEKRE--FIRQGP-RALVKRPDAEEV-VTQVKTLD 659

  Fly   690 FNYEDQ-SNPERLYPKFPVTEDLRVETDRTDSSKEEG-----TMLGLLRTLEGIKDKYLDAPKRI 748
            |||..| ..|||:||.||..:.::......|  .|.|     :.|.||:|.:.||.||.:....:
  Fly   660 FNYNSQVLGPERMYPYFPQMDPIKYPIPFDD--LEPGPVNPTSALELLKTFDNIKSKYQEKHIDL 722

  Fly   749 VEQTTHAVRMSRK-----AYSDPIPTTRSRRQSYFGRRSVRQLDSSIMSIARPVDIEYELSETSD 808
            :.|.....:.|::     ...|.:|..:..::.:                             |.
  Fly   723 ISQPDEQDKKSKQKKLGVKEEDDVPEAQIAKRKF-----------------------------SK 758

  Fly   809 TGEQMIKSRKDSRL--------PSTILSQSAEPRNAAHWTTEFILESSFNKESKVVIVKTDRLGH 865
            .|:::..|.|..|:        .|::.:.........||||:::.:...::|:..:..||||||.
  Fly   759 LGDKVRSSVKTDRMDRVTVGSDKSSVKTNPMSEEQVTHWTTKYVKDVVIDRETNSITFKTDRLGL 823

  Fly   866 FGFAYRRYAHFPFRHWELEKNEQNHDEIILTLDTYHVRVVFFISKDGIRCHAIDIPKEYVHRPFK 930
            .|.|::||.|||||:|.|:.||:|.|||||.:||:|||:.|:|:..|:|.:..|:.|.|..:|.|
  Fly   824 LGLAFKRYEHFPFRNWSLQPNEENPDEIILCVDTFHVRIFFYITCKGVRGYVTDLSKGYTAKPIK 888

  Fly   931 YIDIDKPISDFVELRKRLQDMNLNVFAELDACFYIDQGYFSQKHLAAELHIYDAIAVHGKLMKFS 995
            |::|.:|||||.::|:.....|:|:|||.||.|||:.||||.||:|.|:|.|:.:|:|.|||||.
  Fly   889 YLEIVEPISDFRQMRQIFISKNINIFAENDASFYIENGYFSMKHVALEMHTYNIMALHCKLMKFY 953

  Fly   996 RSQWNRLAKDRDLVLCLQNTRDIHDGSEVTVRVTPEVSTFVDVSELCSDDTKVIKLNYKSTWRNM 1060
            ||.|||||..||:::.::..:|..|.||||:|:|||.:|||.:||.|||...||.|||.:||||:
  Fly   954 RSSWNRLADRRDIIMGMKIAKDNSDYSEVTMRITPEKTTFVQISENCSDKVNVIVLNYINTWRNI 1018

  Fly  1061 GTYSDLHQLINSMYPQATDMRNRDANQMYYIRQLLQEIRPLSFS 1104
            |.::||||.||||.|.||::||:|:..:||:.::|:|||.||||
  Fly  1019 GNFTDLHQAINSMVPNATEVRNKDSILLYYVTRMLKEIRLLSFS 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12983	NP_001137992.1	Casc1_N	17..152	CDD:464947	49/140 (35%)
		Casc1_C	838..1056	CDD:432508	111/217 (51%)
CG33286	NP_001097653.1	Casc1_C	793..1014	CDD:432508	111/220 (50%)