Protein Alignment CG12983 and LOC1269736

DIOPT Version :10

• Sequence 1: NP_001137992.1
• Gene: CG12983 / 40319
• FlyBaseID: FBgn0037040
• Length: 1104
• Species: Drosophila melanogaster
• Sequence 2: XP_061498854.1
• Gene: LOC1269736 / 1269736
• VectorBaseID: AGAMI1_006499
• Length: 1039
• Species: Anopheles gambiae
• Alignment Length: 1184
• Identity: 233/1184 - (19%)
• Similarity: 460/1184 - (38%)
• Gaps: 260/1184 - (21%)

  Fly     2 VKRKNQDAVSIKPAVELLSEEEWMARRNIYMQRLADLKTSVAFIDDAVEEYKELQKQKLRNDKWN 66
            |:.:....|..|...|....:|.:|.:    .|...|:.|..::....||.:::.....:..:|.
Mosquito    35 VEEEKMRKVREKEEAERKQVQEIVANK----LRKVQLEESYTYLASIREEVRKVLADAKKEREWE 95

  Fly    67 SYLACDGLPNPSRPAEIRKFIFQLNFMEQESCAN-------EISWVLSVDECSVLSQAPDRCDRT 124
            .|:.|:||||...||::||::       ...|.|       |.:|:|..:|.|:|:|..:..:.:
Mosquito    96 QYMRCNGLPNAFDPADLRKYL-------HIWCENIRDTNEAERNWLLQTNEQSILTQNVNVANLS 153

  Fly   125 RKIMEKSRPNVGQLYDETVQRILATIERVQRVLRNDDELVHLPTFQVRELDKIPNELYGEIESFF 189
            .:.::..:|.:|..|......:|..:|.:...|.:.|    :....|.:|:::..|....:..:.
Mosquito   154 MESLKLQQPQIGNTYAAKAVEVLGILEEIDEALHDSD----VRPSMVEDLNELKMEFRNVLADYI 214

  Fly   190 DKLTYRVVSSPDALMMNKDSILS-----CYCYKCSNFDLEIWGLQDVPIRFNYLKLPVM------ 243
            |:..|:::|:     :|:|..|:     .:.::...|...::||:|:|       .|.:
Mosquito   215 DEFAYKILSN-----INRDMELNGLLEVSHKFESPVFKTHLFGLRDMP-------TPQLNPKERA 267

  Fly   244 -------CSDLNCVGVTIQLPLSVLCDNLTLRCVRTFFDPLSHLAKSFELVIDSSVIPNCGLVDI 301
                   ..|...:|..:.||.:|.|....:|.:...:|..|....|:::.....     .|.|:
Mosquito   268 KEDSKHTSIDFPSLGFHLTLPAAVKCHKAAIRGLWISYDHCSDYCPSYDMPYKQE-----NLADL 327

  Fly   302 ADSVMSEWMTQMDIQEDLVVKMETEMRAYNEAIAFIAQAEAKEKRKSQKKKIAIPKPPKMPQELP 366
            ......||..:.:|           ::|..|        |.|||:...      .:..:.||::
Mosquito   328 RIISRIEWKKRKEI-----------LKAVYE--------EPKEKKTDS------DEDDQTPQDI- 366

  Fly   367 AGMFPDPRKIFLEHE----KRDCTDFFNRYFHPGNINLLPSEVNLRRFIILGGIVSLVFVGK-AK 426
                 |..||:.||.    |::.|....:     .:||...:||:|...|:.|:.::.::.: .:
Mosquito   367 -----DVDKIYTEHADELMKKERTKKGAK-----TLNLSEYDVNMRSHRIVAGVYAIDYLEQPMQ 421

  Fly   427 HASYEKFNI--TLHEDGRVLRKSLNILDESSTEECSMQPSKLDIGTDIMRDTEVGEASKIPLHLE 489
            .....|..:  |:.:.|::.||...   :......:.||.       :.|..|..||....:...
Mosquito   422 DVKIAKKTLLRTVPQPGKLKRKKFY---QPYRPPPTPQPG-------VRRLPEEIEAEIKQMEEN 476

  Fly   490 PDELPYYFLTFKVPNHLCLWGEPIVC--QFFESEIEETPSKA-------KAEELDKKLDKKKKPV 545
            .|:|.  .::..:|.::..:..||||  :..|..:|..|:.|       ||::..::.:::....
Mosquito   477 LDKLA--LVSVLLPENVFWFEPPIVCRWELKEETLESDPNFAKYLDRLEKAQQAARERNERSNLD 539

  Fly   546 RKSSRKENESVLRVP-------------------TTSGSVSMSEEKPPQSNRPTYHQPARENSVN 591
            |::...|:.::|.||                   :.|..:|::|:|
Mosquito   540 RRTKYVEDFNILDVPQHIPLRAIVTDFVIPKLPDSCSIKISVAEDK------------------- 585

  Fly   592 IYRPSALTIVRQSGMETEQIQYKKTFKNSNLVKEPISKRNLSLLQDQCLPRIISSLRFPRDFQDD 656
             .|.:..|.|..||......:.|:     .|.|.|.:....|::.:..:|..:.:.|.|
Mosquito   586 -RRAAQPTAVAGSGGGKRSSKQKR-----RLHKMPSNVSLGSIVYETKIPDFLYATRNP------ 638

  Fly   657 KMEAQAMKKIPVTQLYKRQLTESVGSTQIEKFSFNYEDQSNPERLYPKFPVTEDLRVETDRTDSS 721
                  ::.:.|.....||.....|::..:... :|::..|                :..:..|:
Mosquito   639 ------LRILKVLDRRNRQCYPYAGTSDSDDLD-DYDESDN----------------DVVQNRST 680

  Fly   722 KEEGTML-GLLRTLEGIKDKYLDAPKRIVEQTTHAVRMSRKAYSDPIPTTRSRRQSYFGRRSVRQ 785
            |.:..|. ..::.|:.:.:......:..:||...|..          ||....:||
Mosquito   681 KRKVYMFSSFMKDLDELLESKSPKLQAKLEQELGAGG----------PTGGPGKQS--------- 726

  Fly   786 LDSSIMSIARPVDIEYELSETSDTGEQMIKSRKDSRLPSTILSQSAE----------PRNAAHWT 840
                 :.:||..:......|..:.|::..||:.||...........|          .|....|:
Mosquito   727 -----LQVARSDETRTVRGEKGEKGKKPAKSKFDSDDEDVDYGNILEVGNYSMVENDKRYIGKWS 786

  Fly   841 TEFILESSFNKESKVVIVKTDRLGHFGFAYRRYAHFPFRHWELEKNEQNHDEIILTLDTYHVRVV 905
            |..:.:..||::...:..:..|||.|.||..||::.|::.|||:.:.:|...:..:|....|...
Mosquito   787 TRDVHDVKFNEDKLTIQFRVGRLGSFAFAANRYSNVPYQSWELKPDIKNPGTVTFSLTASVVSTE 851

  Fly   906 FFISKDGIRCHAID-IPKEYVHRPFKYIDIDKPISDFVELRKRLQDMNL---NVFAELDACFYID 966
            ..|::.|.|.:::. .|.:         .:.:.:...:.|||.::.:.|   ::|.|.||..|.:
Mosquito   852 MTITEAGFRVNSLQGGPTQ---------ALQEILGLTMSLRKLIKTLRLAAVDLFPEDDAFNYTE 907

  Fly   967 QGYFSQKHLAAELHIYDAIAVHGKLMKFSRSQWNRLAKDRDLVLCLQNTRDIHDGSEV----TVR 1027
            .  ..:|:...|.|:||.|.:......||.|:||.|:..|   :|:...|:|.:...:    |:.
Mosquito   908 G--TCEKNPIMESHLYDCIGLLALTHNFSWSRWNLLSGCR---MCVLLMREIVEHRRLPNHSTLL 967

  Fly  1028 VTPEVSTFVDVSELCSDDTKVIKLNYKSTWRNMGTYSDLHQLINSMYPQATDMRNRDANQMY--Y 1090
            |||..::.:|..|:    :.|...|   ....|..|:||:.|.......::.::....:.:.  .
Mosquito   968 VTPLKASVIDTVEV----SPVFNPN---PVEGMNHYADLYHLGRDQSQPSSRIKQEKMSPILREN 1025

  Fly  1091 IRQLLQEIRPLSFS 1104
            :.|||:.:||||||
Mosquito  1026 VTQLLKSVRPLSFS 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12983	NP_001137992.1	Casc1_N	17..152	CDD:464947	32/141 (23%)
		Casc1_C	838..1056	CDD:432508	56/225 (25%)
LOC1269736	XP_061498854.1	None