DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10588 and STE23

DIOPT Version :9

Sequence 1:	NP_001287135.1	Gene:	CG10588 / 40316	FlyBaseID:	FBgn0037037	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_013493.2	Gene:	STE23 / 851105	SGDID:	S000004381	Length:	1027	Species:	Saccharomyces cerevisiae

Alignment Length:	1076	Identity:	291/1076 - (27%)
Similarity:	493/1076 - (45%)	Gaps:	176/1076 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTENFNGKLAACAVLVGVGSFS 106
            |.|.|.:.||.:.|.|.|:|:||.|...|:                      ||.::.|.:|:|.
Yeast    66 KPDLDERSYRFIELPNKLKALLIQDPKADK----------------------AAASLDVNIGAFE 108

  Fly   107 EPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMD 171
            :|:...|||||.||::||||||||.|||:.|:::|.||.|||:|.::.|.::||::..||...:|
Yeast   109 DPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173

  Fly   172 LFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTL-- 234
            .|......||...|:..:|.:||.||.::....|..|..|:..||.:..:|:..||.||.:||
Yeast   174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGT 238

  Fly   235 --KEGVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELEELLVRHCADIPTSQQNSIDVSQL 297
              ||  :..::..||.||:::.|.:|.|.:.:..:..||.|.:.......|:   ..|..:| .|
Yeast   239 LPKE--NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDV---ANNGREV-PL 297

  Fly   298 NYQKAFRDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMFISQLIGYEGVGSLCAYLRH 362
            ..:...:.:..:.:..|:||:|:.|||:::.:|.|:..:.|||...:|.|||:||.|||.|:|:.
Yeast   298 YAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362

  Fly   363 HLWCISVVAG---VAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLEATFAWVKLIINSDQLQDS 424
            ..|...:.||   |::.:       :.|.:.|.|:|:|..|..:|:...|.:::::.||...:..
Yeast   363 LGWANELSAGGHTVSKGN-------AFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420

  Fly   425 YKESQQIENNNFRFQIEPPPIDHVQSIVESF--NYLPSKDVLT-------GPQLYFQY------E 474
            :.|.|.|.|..|:|:....|...|.|:.:..  :|:|...:|.       .|.|..||      |
Yeast   421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPE 485

  Fly   475 ESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIKELH 539
            .|.:.|:.:.:                  |.|..|.|:||.:|.:..|.......:.......|.
Yeast   486 NSRVTLISRSL------------------ETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALT 532

  Fly   540 YPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRNDLCELWFRQDNIFKLPDGYINLYFITPLVRE 604
            .|:||.||:|:||:..::..||  ...|..|:.:|:.:||:::|:.|..|.|||.|.|..|....
Yeast   533 LPRPNEFVSTNFKVDKIDGIKP--LDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHA 595

  Fly   605 SVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQ 669
            |:...||..|:|.|....:.:..|.|..|.|.......::||.:..||:||||.:|:...|..:.
Yeast   596 SIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660

  Fly   670 TIELDIGQVNAFKDLKKRQI---------------YNALINGKSLNLDLRLSILENKRFSMISKY 719
            :.|....:....||...|.:               |||:||.:|              :|...|.
Yeast   661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS--------------WSTAEKL 711

  Fly   720 ESVDDITMDDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHLLQ 784
            :..:.:|.:.:.:|....::.:|.:.||.||...::|.: :..::.:.....:.||...:|.|..
Yeast   712 QVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALE-VDSLIKSLIPNNIHNLQVSNNRLRS 775

  Fly   785 --IPLGSYYLRAKTLNEDDS--NTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLG 845
              :|.|..: |.:|..:|..  |:.|.:..|:......:..:..|...::.||.|:.|||:||||
Yeast   776 YLLPKGKTF-RYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLG 839

  Fly   846 Y-----SLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRE 905
            |     ||..|   |...:..||     :::|...|:|.||..|.....:::..|.:.:|:..:|
Yeast   840 YVVFSSSLNNH---GTANIRILI-----QSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKE 896

  Fly   906 TLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNF-----LNDNDKNN 965
            .|.|.......::.||..|..:.|...:|.|...:.:.::::::||:.:::|     :::|....
Yeast   897 ALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKL 961

  Fly   966 LRKLSVQVVGNHNQTSNSTAQASRSGSLSDLLDDVQDNMANETDSAKPMTDKIRLEFLGESDDPS 1030
            :..|..||   .|:..|.                      ||.|:||..|.::
Yeast   962 ILHLKSQV---ENKELNE----------------------NELDTAKYPTGQL------------ 989

  Fly  1031 SIKDIYAFKKDLYVFPL--------FNTNPNLANKS 1058
             |:|:.|||..|:|.|:        .:..|.|.|.|
Yeast   990 -IEDVGAFKSTLFVAPVRQPMKDFEISAPPKLNNSS 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	272/988 (28%)
		Peptidase_M16	85..214	CDD:279066	50/128 (39%)
		Peptidase_M16_C	244..419	CDD:282978	50/177 (28%)
		Peptidase_M16_M	436..720	CDD:292805	80/313 (26%)
		Peptidase_M16_C	724..907	CDD:282978	47/191 (25%)
STE23	NP_013493.2	Ptr	51..968	CDD:223956	269/980 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S927
OMA	1	1.010	-	-		QHG63000
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.670