DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10588 and nrd1b

DIOPT Version :9

Sequence 1:	NP_001287135.1	Gene:	CG10588 / 40316	FlyBaseID:	FBgn0037037	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001038180.2	Gene:	nrd1b / 557565	ZFINID:	ZDB-GENE-050208-422	Length:	1061	Species:	Danio rerio

Alignment Length:	1048	Identity:	364/1048 - (34%)
Similarity:	559/1048 - (53%)	Gaps:	81/1048 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTEN------------------ 88
            ||..|.|.||.:.|||||:|:|||    |..|...:.|||::...|.
Zfish    46 KSPNDYKTYRYIELSNGLKALLIS----DVSSQSESCRESVDKEVEEEGDRGSASDISKHSERGK 106

  Fly    89 ---FNGKLAACAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHT 150
               .:.|.:|.|:.:.|||||:|....|||||:|||:||||||:||||.||:|:.|.||..||.|
Zfish   107 QSCRSEKQSAAALCISVGSFSDPADLPGLAHFLEHMVFMGSEKYPVENGFDAFLKKHGGSDNAST 171

  Fly   151 ENEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILAS 215
            :.|.|.|.|::.:.:|...:|.:......|||:|||:.||..||.||::.....|..|::.:..|
Zfish   172 DCERTIFQFDVQRKYLREALDRWAQFFICPLMIPDAVDREVEAVDSEYQMAQPLDSNRKEMLFGS 236

  Fly   216 LASEGYPHGTFSWGNYKTLKEGVDDSSL--HKELHKFYRDHYGSNRMVVALQAQLSLDELEELLV 278
            ||..|:|...|.|||.:|||:...:..:  ::.|..|:|.:|.:..|.:|:|::.:||.|||.:.
Zfish   237 LAKAGHPMSKFFWGNAQTLKQEPREKKINTYERLRDFWRRYYSAQYMTLAVQSKETLDTLEEWVR 301

  Fly   279 RHCADIPTSQQNSIDVSQLNYQKAFRDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMF 343
            .....||.:.....|.|.|  |..|....:..::.|.||:.|..|.::|.|||....||.||..:
Zfish   302 EIFVQIPNNGLPKADFSDL--QDPFDTPDFCKLYRVVPVQKVHALTISWALPPQAKHYRVKPLHY 364

  Fly   344 ISQLIGYEGVGSLCAYLRHHLWCISVVAGVAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLEAT 408
            ||.|||:|||||:.:.||...|.:|:..|.:||.||.||.||:|:|.|.|||:|..:..:|:...
Zfish   365 ISWLIGHEGVGSVLSLLRKRCWALSLFGGNSESGFDQNSTYSIFSISITLSDEGLQNFLQVIHII 429

  Fly   409 FAWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQY 473
            |.::|::.:....|..|:|.|:||.|.|.:|.:..||:.|.::.|:....|.:..|.|.||.|.:
Zfish   430 FQYLKMLQSVGPQQRIYEEIQKIEANEFHYQEQTEPIEFVANMSENMQLFPKEHFLCGDQLMFDF 494

  Fly   474 EESA----IELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSAT 534
            ...|    |......:.....||::.|  |........:|.|||||:....:|.:::.:|.....
Zfish   495 NPEASHCVISAALSLLTPGKANILLLS--PQHDGLCPLKEKWFGTQYSVEDIPQEFRDLWAGDFP 557

  Fly   535 I-KELHYPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRNDLCELWFRQDNIFKLPDGYINLYFI 598
            : .||..|..|.|:.|||.:.  .|..|... .|..:|.|:...||||:||.||:|..|.....:
Zfish   558 LHPELQLPAENKFIATDFTLR--TSDCPDTD-FPVKIIDNERGRLWFRKDNKFKIPKAYARFQLL 619

  Fly   599 TPLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEI 663
            ||.::||.|..:|..||..:|...:||..|.|..|.|.|.|..||.||.:|:.|:|.|||||:::
Zfish   620 TPFIQESPKNLVLFDLFVNIVAHNLAELAYDAEVAQLQYNLLPGDHGLFIRLKGFNHKLPLLLKL 684

  Fly   664 ILNMMQTIELDIGQVNAFKDLKKRQIYNALINGKSLNLDLRLSILENKRFSMISKYESV-DDITM 727
            |::.:..........|.|.:..|:..|..||..:.|..|:||.|||:.|:|::.|||:: .|.::
Zfish   685 IVDHLADFSATPDVFNMFIEQLKKTYYIILIRPERLGKDVRLQILEHHRWSVMQKYEAIMADPSV 749

  Fly   728 DDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHLLQIPLGSYYL 792
            .|:.:|...|..:::|:||:|||||..::.:.:|..::..|.........:...::::|...:..
Zfish   750 ADLMTFANRFKAELFVEGLVQGNFTSAESKEFLQCFIEKLKYAPHPIEPPVLFRVVELPQTHHLC 814

  Fly   793 RAKTLNEDDSNTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYG 857
            :.::||:.|:|:.:|.|||.|..:|:...:|:|:.:.:|||.|:.|||:|.|||.:....|...|
Zfish   815 KVQSLNKADANSEVTVYYQTGLKNLREHTLMELLVMHMEEPCFDFLRTKETLGYQVYPICRNTSG 879

  Fly   858 VLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEV 922
            :|.|.:|:.||.||...|:||.:||||.....|.:.|:||..|......||..|:..||.|.:||
Zfish   880 ILGFSVTVETQATKFSTDFVEGKIEAFLVSFGEKLVQLSDEAFGAQVTALIKLKECEDTQLGDEV 944

  Fly   923 LRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLNDNDKNNLRKLSVQVVG------------ 975
            .|||.|:||::|.|:|:..:|::|..:||:::::|..::.|.|.||||:.|||
Zfish   945 DRNWFEVVTQQYVFDRLNKEIEILKDVTKDELVSFYMEHRKENSRKLSIHVVGFGEEEKEIHGED 1009

  Fly   976 --NHNQTSNSTAQASRSGSLSDLLDDVQDNMANETDSAKPMTDKIRLEFLGESDDPSSIKDIYAF 1038
              :.|..::|.|..|:...|                ||..|.:|           .:.|.||.||
Zfish  1010 QCSSNPETSSYANISKLTFL----------------SAAAMKEK-----------STMITDIRAF 1047

  Fly  1039 KKDLYVFP 1046
            ...|::.|
Zfish  1048 TSSLHLHP 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	349/980 (36%)
		Peptidase_M16	85..214	CDD:279066	57/149 (38%)
		Peptidase_M16_C	244..419	CDD:282978	65/174 (37%)
		Peptidase_M16_M	436..720	CDD:292805	95/288 (33%)
		Peptidase_M16_C	724..907	CDD:282978	59/182 (32%)
nrd1b	NP_001038180.2	Ptr	42..1006	CDD:223956	348/970 (36%)
		Peptidase_M16	111..241	CDD:279066	59/129 (46%)
		Peptidase_M16_C	266..452	CDD:282978	69/187 (37%)
		Peptidase_M16_M	457..742	CDD:292805	96/289 (33%)
		Peptidase_M16_C	748..929	CDD:282978	58/180 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595971
Domainoid	1	1.000	173	1.000	Domainoid score	I3639
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134694
Inparanoid	1	1.050	645	1.000	Inparanoid score	I789
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	1	1.000	-	-		mtm6341
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	1	1.100	-	-	O	PTHR43690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4190
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770