DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10588 and IDE

DIOPT Version :9

Sequence 1:NP_001287135.1 Gene:CG10588 / 40316 FlyBaseID:FBgn0037037 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001309722.1 Gene:IDE / 3416 HGNCID:5381 Length:1019 Species:Homo sapiens


Alignment Length:1072 Identity:290/1072 - (27%)
Similarity:509/1072 - (47%) Gaps:96/1072 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 FRPRLGLRRITKQVQKWLNRQQYPMSTASVVVQYHEEPDKSDGDSKLYRALTLSNGLRAMLISDS 67
            ||..||.|....:......::.|.......:.:......||..|.:.||.|.|:||::.:||||.
Human    17 FRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDP 81

  Fly    68 YIDEPSIHRASRESLNSSTENFNGKLAACAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFPVE 132
            ..|:.|                      .|:.|.:||.|:|....||:||.|||:|:|::|:|.|
Human    82 TTDKSS----------------------AALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKE 124

  Fly   133 NEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSE 197
            ||:..|:::..|.|||.|..|.|.:||::...||:..:|.|......||.......||.:||.||
Human   125 NEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSE 189

  Fly   198 FEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTL-----KEGVDDSSLHKELHKFYRDHYGS 257
            .|:..|.|..|..|:..:..:..:|...|..||..||     :||:|   :.:||.||:..:|.|
Human   190 HEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGID---VRQELLKFHSAYYSS 251

  Fly   258 NRMVVALQAQLSLDELEELLVRHCADIPTSQQNSIDVSQLNYQKAFRDQFYKDVFLVQPVEDVCK 322
            |.|.|.:..:.|||:|..|:|:..:::   :..::.:.:.. :..|:::..|.::.:.|::|:..
Human   252 NLMAVCVLGRESLDDLTNLVVKLFSEV---ENKNVPLPEFP-EHPFQEEHLKQLYKIVPIKDIRN 312

  Fly   323 LELTWVLPPMKNFYRSKPDMFISQLIGYEGVGSLCAYLRHHLWCISVVAGVAESSFDSNSIYSLF 387
            |.:|:.:|.::.:|:|.|..::..|||:||.|||.:.|:...|..::|.|..|.:..    :..|
Human   313 LYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARG----FMFF 373

  Fly   388 NICIYLSDDGFDHIDEVLEATFAWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIV 452
            .|.:.|:::|..|:::::...|.:::.:......:..::|.:.:....|||:.:..|..:...|.
Human   374 IINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIA 438

  Fly   453 ESFNYLPSKDVLTGPQLYFQYEESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFK 517
            ...:|.|.::|||...|..::....||::...:...|..:.|.|. .:| .:.|:.|.|:|||:|
Human   439 GILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK-SFE-GKTDRTEEWYGTQYK 501

  Fly   518 TISMPPKWQTMWEQSATIKELHYPQPNPFVTTDFKIHWVE-SGKPHVSRSPKALIRND-LCELWF 580
            ..::|.:....|:.:....:...|..|.|:.|:|:|..:| ...|:     .|||::. :.:|||
Human   502 QEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPY-----PALIKDTAMSKLWF 561

  Fly   581 RQDNIFKLPDGYINLYFITPLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKG 645
            :||:.|.||...:|..|.:..:........:..||..|::..:.|..|.|..:||:||:..|...
Human   562 KQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYGIASGMNA 626

  Fly   646 LVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDLKKRQIYNALINGKSLNLDLRLSILEN 710
            :::.|.|||:|.|:|::.|:..|.|.|:|..:....|:...|.:.|........:....|.:|..
Human   627 ILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMT 691

  Fly   711 K-RFSMISKYESVDDITMDDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDN 774
            : .::.....|::||:|:..:|:|......:::::.|:.||.|:..|..:||.|.||. .|....
Human   692 EVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEHAHT 755

  Fly   775 LSALDNHL-----LQIPLGSYYLRAKTLNEDDSNTIITNYYQIGPSDLKMECIMDLVELIVEEPF 834
            ...|.:.|     :|:|...:::..:. ||..:|..|..|||...........::|...|:.||.
Human   756 KPLLPSQLVRYREVQLPDRGWFVYQQR-NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPC 819

  Fly   835 FNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTE 899
            ||.|||:|||||.:....|...|:......|.:::..|   |:|.|:|||...|.:.:..|::..
Human   820 FNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPH---YLESRVEAFLITMEKSIEDMTEEA 881

  Fly   900 FKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLNDN--- 961
            |:...:.|...:......|..|..:.|.||::::|.|:|..|::..|..|||||::.|..:.   
Human   882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAV 946

  Fly   962 DKNNLRKLSVQVVGNHNQTSNSTAQASRSGSLSDLLDDVQDNMANETDSAK-----PMTDKIRLE 1021
            |.....|:||.|                              :|.|.||..     |..:.|.|.
Human   947 DAPRRHKVSVHV------------------------------LAREMDSCPVVGEFPCQNDINLS 981

  Fly  1022 FLGESDDPSSIKDIYAFKKDLYVFPLFNTNPN 1053
            .......|..|:::..||:.|.:|||...:.|
Human   982 QAPALPQPEVIQNMTEFKRGLPLFPLVKPHIN 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10588NP_001287135.1 Ptr 27..980 CDD:223956 268/968 (28%)
Peptidase_M16 85..214 CDD:279066 47/128 (37%)
Peptidase_M16_C 244..419 CDD:282978 44/174 (25%)
Peptidase_M16_M 436..720 CDD:292805 75/286 (26%)
Peptidase_M16_C 724..907 CDD:282978 53/187 (28%)
IDENP_001309722.1 Ptr 52..958 CDD:223956 267/950 (28%)
Peptidase_M16 74..212 CDD:279066 53/159 (33%)
Peptidase_M16_C 238..416 CDD:282978 45/185 (24%)
Peptidase_M16_M 422..703 CDD:292805 75/287 (26%)
Peptidase_M16_C 706..889 CDD:282978 53/187 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S927
OMA 1 1.010 - - QHG63000
OrthoDB 1 1.010 - - D1008844at2759
OrthoFinder 1 1.000 - - FOG0000548
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100422
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.680

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