Protein Alignment CG10588 and Nrd1

DIOPT Version :10

• Sequence 1: NP_649271.1
• Gene: CG10588 / 40316
• FlyBaseID: FBgn0037037
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: NP_572757.2
• Gene: Nrd1 / 32143
• FlyBaseID: FBgn0030344
• Length: 1147
• Species: Drosophila melanogaster
• Alignment Length: 1085
• Identity: 492/1085 - (45%)
• Similarity: 713/1085 - (65%)
• Gaps: 68/1085 - (6%)

  Fly    34 VQYHEEPDKSDGDSKLYRALTLSNGLRAMLISD------------------SYIDEPS--IHRA- 77
            |:|.:.||||:.|.|||:.|.|.|||.|:::||                  |.:...|  |.|:
  Fly    47 VKYLDIPDKSETDKKLYKTLLLGNGLHALIVSDPSPMPHDGFTTSESSSSKSTVSTSSSIISRSE 111

  Fly    78 --------SRESLNSSTENFNGKLAACAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFPVENE 134
                    |..|..||:|..:.||||||:|:..|||:||.:|||||||:||||||||||:|.||.
  Fly   112 STSSTSTDSESSEESSSEEGDEKLAACALLIDYGSFAEPTKYQGLAHFLEHMIFMGSEKYPKENI 176

  Fly   135 FDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFE 199
            ||:.:.|.|||:||:|:.|:|.||||:.:.|||..:|.|..|||||||..:||.||||||.|||:
  Fly   177 FDAHIKKCGGFANANTDCEDTLFYFEVAEKHLDSSLDYFTALMKAPLMKQEAMQRERSAVDSEFQ 241

  Fly   200 QTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTLKEGVDDSSLHKELHKFYRDHYGSNRMVVAL 264
            |....||.||||:|||||::|:|||||:|||.|:|||.|||:.|||.||:..::|||:|||.|.|
  Fly   242 QILQDDETRRDQLLASLATKGFPHGTFAWGNMKSLKENVDDAELHKILHEIRKEHYGANRMYVCL 306

  Fly   265 QAQLSLDELEELLVRHCADIPTSQQNSIDVSQLNYQKAFRDQFYKDVFLVQPVEDVCKLELTWVL 329
            ||:|.:||||.|:|||.:.||.::..:.|:|..||:.||:.:|::.||.|:|||:..||||||||
  Fly   307 QARLPIDELESLVVRHFSGIPHNEVKAPDLSSFNYKDAFKAEFHEQVFFVKPVENETKLELTWVL 371

  Fly   330 PPMKNFYRSKPDMFISQLIGYEGVGSLCAYLRHHLWCISVVAGVAESSFDSNSIYSLFNICIYLS 394
            |.::.:||||||.|:|.|:||||.||||||||..||.:.::||:.|:.||.||:||||||||||:
  Fly   372 PNVRQYYRSKPDQFLSYLLGYEGRGSLCAYLRRRLWALQLIAGIDENGFDMNSMYSLFNICIYLT 436

  Fly   395 DDGFDHIDEVLEATFAWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIVESFNYLP 459
            |:||.::||||.||||:|||..|...::|.|:|.|:.|...|||..:.|..|:||.:|.:..|.|
  Fly   437 DEGFKNLDEVLAATFAYVKLFANCGSMKDVYEEQQRNEETGFRFHAQRPAFDNVQELVLNLKYFP 501

  Fly   460 SKDVLTGPQLYFQYEESAIELLRQHMNKFNFNIMISSYIPYEK-NEYDQREPWFGTQFKTISMPP 523
            .||:|||.:||::|.|..::.|..|:|:..||:|::|...|:. :.||:.|.||||::.||.||.
  Fly   502 PKDILTGKELYYEYNEEHLKELISHLNEMKFNLMVTSRRKYDDISAYDKTEEWFGTEYATIPMPE 566

  Fly   524 KWQTMWEQSATIKELHYPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRNDLCELWFRQDNIFKL 588
            ||:.:||.|..:.||..|:.|.:||.||.:||...|:|.|..|||.||:.|.||||||||:.|.|
  Fly   567 KWRKLWEDSVPLPELFLPESNKYVTDDFTLHWHSMGRPEVPDSPKLLIKTDTCELWFRQDDKFDL 631

  Fly   589 PDGYINLYFITPLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGY 653
            |:.::..|||:|:.|::.|...:..|:..:|.|.:.|:||||:.|||:|.|...:|||:::|.||
  Fly   632 PEAHMAFYFISPMQRQNAKNDAMCSLYEEMVRFHVCEELYPAISAGLSYSLSTIEKGLLLKVCGY 696

  Fly   654 NEKLPLLVEII----LNMMQTIELDIGQVNAFKDLKKRQIYNALINGKSLNLDLRLSILENKRFS 714
            ||||.|:||.|    ||:.:|  ||...::||...:::..:||||..|:||.|:||.:||..|:.
  Fly   697 NEKLHLIVEAIAEGMLNVAET--LDENMLSAFVKNQRKAFFNALIKPKALNRDIRLCVLERIRWL 759

  Fly   715 MISKYESVDDITMDDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKL-DNLSAL 778
            ||:||:.:..:.::|::.|...|.|::|::.|||||:||:.|.::|..:|.....::: :....|
  Fly   760 MINKYKCLSSVILEDMREFAHQFPKELYIQSLIQGNYTEESAHNVMNSLLSRLNCKQIRERGRFL 824

  Fly   779 DNHLLQIPLGSYYLRAKTLNEDDSNTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQ 843
            ::..:::|:|:..:|...||..|:||:|||:|||||:.:::|.|:||:.:.|:||.|:||||:||
  Fly   825 EDITVKLPVGTSIIRCHALNVQDTNTVITNFYQIGPNTVRVESILDLLMMFVDEPLFDQLRTKEQ 889

  Fly   844 LGYSLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLI 908
            |||.:|...|:.||:..:.|.:|:||||..|||||.|||.||::|.:::..:...|:::.|::||
  Fly   890 LGYHVGATVRLNYGIAGYSIMVNSQETKTTADYVEGRIEVFRAKMLQILRHLPQDEYEHTRDSLI 954

  Fly   909 NGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLNDNDKNNLRKLSVQV 973
            ..|.:.|.:|..|:.|||.||:.:.|.|:|...||::|..|.|::::||:...|.:|:|||||||
  Fly   955 KLKLVADLALSTEMSRNWDEIINESYLFDRRRRQIEVLRTLQKDEIINFVISIDGDNMRKLSVQV 1019

  Fly   974 VGNHNQ------TSNSTAQ-ASRSGSLSDLL---DDVQDNMANETDSAKPMTDKIRLEFLGESDD 1028
            :|:...      ....||: ||:|...|:..   ||.:|....|:...:...:|.:....||.:|
  Fly  1020 IGHRPAGMPEPLCGEDTAKCASKSDDESESENDDDDDEDEEEEESSEEEEEEEKEKEGLKGEDED 1084

  Fly  1029 ---------------PSS------IKDIYAFKKDLYVFPLFNTNP 1052
                           |:.      |.||..||.|.||:|...|.|
  Fly  1085 DLFYSLENKLNIVFLPAKFNNAFIITDIEKFKDDQYVYPQQKTQP 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_649271.1	Ptr	38..996	CDD:440648	470/999 (47%)
Nrd1	NP_572757.2	Ptr	55..1030	CDD:440648	462/976 (47%)