DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10588 and C02G6.2

DIOPT Version :9

Sequence 1:	NP_001287135.1	Gene:	CG10588 / 40316	FlyBaseID:	FBgn0037037	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_504531.2	Gene:	C02G6.2 / 182128	WormBaseID:	WBGene00015360	Length:	816	Species:	Caenorhabditis elegans

Alignment Length:	887	Identity:	221/887 - (24%)
Similarity:	394/887 - (44%)	Gaps:	154/887 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SVVVQYHEEPDKSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTENFNGKLAA 95
            ::|::.:....|...|.:..|.|.|:||||.:|:||...|:                      :|
Worm     7 NIVLKRYNSIVKGPQDERECRGLELTNGLRVLLVSDPTTDK----------------------SA 49

  Fly    96 CAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFE 160
            .::.|..|...:|.:..|||||.|||:|:|:.|:|:||||..|::.:.|..||.||.:.|.::|:
Worm    50 VSLAVKAGHLMDPWELPGLAHFCEHMLFLGTSKYPLENEFTKFLSDNAGSYNACTEPDHTYYHFD 114

  Fly   161 LDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGT 225
            :....|...:|.|:.....|.....|..||..||.||.......|..|..|:..||:..|:.:..
Worm   115 VKPDQLYGALDRFVQFFLCPQFTKSATEREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRK 179

  Fly   226 FSWGNYKTL-----KEGVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELEELLVRHCADIP 285
            |..||.|||     |:|::.   ...|.:||:..|.||.|...:..:.|||.||..|
Worm   180 FCTGNKKTLLEDARKKGIEP---RDALLEFYKKWYSSNIMTCCIIGKESLDVLESYL-------- 233

  Fly   286 TSQQNSIDVSQLNYQKA-------FR---DQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKP 340
                .:::...:..:||       |:   ||..|.:.:| |::|...:.:.:..|.:.|.|.|:|
Worm   234 ----RTLEFDAIQNKKAESKVWAEFQYGPDQLAKKIDVV-PIKDKKLVSIIFPFPDLNNEYLSQP 293

  Fly   341 DMFISQLIGYEGVGSLCAYLRHHLWCIS-------VVAGVAESSFDSNSIYSLFNICIYLSDDGF 398
            ..:|:.|||::|.||:.:.|:...|..|       :.||           :..||:.:.||.:|.
Worm   294 GHYIAHLIGHKGPGSISSELKRLGWASSLKPESKTIAAG-----------FGYFNVTMDLSTEGL 347

  Fly   399 DHIDEVLEATFAWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIVESFNYLPSKDV 463
            :|:||:::..|.::.::.::...|..::|..::....|||:...|...:...:..:..|:|.:.:
Worm   348 EHVDEIIQLMFNYIGMLQSAGPQQWIHEELAELSAIEFRFKDREPLTKNAIKVARNLQYIPFEHI 412

  Fly   464 LTGPQLYFQYEESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTM 528
            |:...|..:|....|:.|...:...|..:.:.|. .:::.|.:..||.:||:.|...:.|:....
Worm   413 LSSRYLLTKYNPERIKELLSTLTPSNMLVRVVSK-KFKEQEGNTNEPVYGTEMKVTDISPEKMKK 476

  Fly   529 WEQSATIKE--LHYPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRNDLCELWFRQDNIFKLPDG 591
            :|.:.....  ||.|:.|.::.|.|.....||.|   :..|:.:..:....:||:||:.:.:|..
Worm   477 YENALKTSHHALHLPEKNEYIVTKFDQKPRESVK---NEHPRLISDDGWSRVWFKQDDEYNMPKQ 538

  Fly   592 YINLYFITPLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKG----------- 645
            ...|.|.||:|.::....::..|:.:.:...:.|:.|.|..|||.:.|..|..|
Worm   539 ETKLAFTTPIVAQNPIMSLISSLWLWCLNDTLTEETYNAAIAGLKFQLESGHNGVHEQAGNWLDP 603

  Fly   646 -----LVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVN-AFKDLKKRQIYNALINGKSLNLDLR 704
                 :.:.|.||:||.||.|:.:...|...::|..:.: .|:.||:.
Worm   604 ERHASITLHVYGYDEKQPLFVKHLTKCMTNFKIDRTRFDVVFESLKRS----------------- 651

  Fly   705 LSILENKRFS---MISKY-------ESV----------DDITMDDIKSFKENFHKKMYVKGLIQG 749
               |.|..||   |:|||       |.|          |..|::|::.|.:...:..:::..:.|
Worm   652 ---LTNHAFSQPYMLSKYFNELLVVEKVWSKEQLLAVCDSATLEDVQGFSKELFQAFHLELFVHG 713

  Fly   750 NFTEDQATDLMQKVLDTYKSEKLDNLSALDNHLL-----------QIPLGSYYLRAKTLNEDDSN 803
            |.||.:|..|..:::|..||      :|.::.||           |:..|..|:........|:.
Worm   714 NSTEKKAIQLSNELMDILKS------AAPNSRLLYRNEHNPRREFQLNNGDEYIYRHLQKTHDAG 772

  Fly   804 TI-ITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQL 844
            .: :|  ::.|..:.....:..|:..::.:|.|:.|||:|.|
Worm   773 CVEVT--FKFGVQNTYDNALAGLISQLIRQPAFSTLRTKESL 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	221/887 (25%)
		Peptidase_M16	85..214	CDD:279066	42/128 (33%)
		Peptidase_M16_C	244..419	CDD:282978	48/191 (25%)
		Peptidase_M16_M	436..720	CDD:292805	72/312 (23%)
		Peptidase_M16_C	724..907	CDD:282978	29/133 (22%)
C02G6.2	NP_504531.2	PqqL	31..451	CDD:223685	125/469 (27%)
		Peptidase_M16	36..174	CDD:279066	49/159 (31%)
		Peptidase_M16_C	200..377	CDD:282978	49/200 (25%)
		Peptidase_M16_M	385..685	CDD:292805	74/323 (23%)
		Peptidase_M16_C	688..>812	CDD:282978	28/131 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S927
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.680