DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10588 and F44E7.4

DIOPT Version :9

Sequence 1:	NP_001287135.1	Gene:	CG10588 / 40316	FlyBaseID:	FBgn0037037	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_741543.1	Gene:	F44E7.4 / 178966	WormBaseID:	WBGene00018426	Length:	1067	Species:	Caenorhabditis elegans

Alignment Length:	1028	Identity:	265/1028 - (25%)
Similarity:	480/1028 - (46%)	Gaps:	99/1028 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RPRLGLRRITKQVQKWLNRQQYPMST---ASVVVQYHEEPDKSDGDSKLYRALTLSNGLRAMLIS 65
            ||:....|: :.|:...|....|..|   .::|::.|:...|...|::.||.|.|:||:|.:|:|
Worm    37 RPQNSSLRL-RLVRNISNSNPLPKMTEAGKNIVLKRHDLIVKGAQDAREYRGLELTNGIRVLLVS 100

  Fly    66 DSYIDEPSIHRASRESLNSSTENFNGKLAACAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFP 130
            |...|:                      :|.|:.|.||...:|.:..|||||.|||:|:|:.|:|
Worm   101 DPTTDK----------------------SAAALDVKVGHLMDPWELPGLAHFCEHMLFLGTAKYP 143

  Fly   131 VENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQ 195
            .|||:..|:....|.|||:|.::.|.::|::....|...:|.|:....:|.....|..||..||.
Worm   144 SENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREVCAVD 208

  Fly   196 SEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTL-----KEGVDDSSLHKELHKFYRDHY 255
            ||.......|..|..|:..|.:..|:.:|.|..||.:||     |:|::.   ...|.:|::..|
Worm   209 SEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEP---RDALLQFHKKWY 270

  Fly   256 GSNRMVVALQAQLSLDELEELLVRHCADIPTSQQNSIDVSQLNYQKAFR----------DQFYKD 310
            .|:.|...:..:..|:.||..|            .:::...:..:|..|          ||..|.
Worm   271 SSDIMTCCIVGKEPLNVLESYL------------GTLEFDAIENKKVERKVWEEFPYGPDQLAKR 323

  Fly   311 VFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMFISQLIGYEGVGSLCAYLRHHLWCISVVAGVAE 375
            :.:| |::|...:.:::..|.:...:.|:|..:||.|||:||.|||.:.|:...|    |:.:..
Worm   324 IDVV-PIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKRLGW----VSSLQS 383

  Fly   376 SSFDSNSIYSLFNICIYLSDDGFDHIDEVLEATFAWVKLIINSDQLQDSYKESQQIENNNFRFQI 440
            .|....:.:.::|:.:.||.:|.:|:||:::..|.::.::.::...|..:.|..::....|||:.
Worm   384 DSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHDELAELSAVKFRFKD 448

  Fly   441 EPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYEESAIELLRQHMNKFNFNIMISSYIPYEKNEY 505
            :..|:....::..|..|:|.:.:|:...|..:||...|:.|...::..|..:.:.|. .::..|.
Worm   449 KEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQ-KFKGQEG 512

  Fly   506 DQREPWFGTQFKTISMPPKWQTMWEQSATIKE--LHYPQPNPFVTTDFKIHWVESGKPHVSRSPK 568
            :..||.:||:.|...:.|:....:|.:.....  ||.|:.|.::.|:|.....||.|   :..|:
Worm   513 NTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVK---NEHPR 574

  Fly   569 ALIRNDLCELWFRQDNIFKLPDGYINLYFITPLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEA 633
            .:..:....:||:||:.:.:|.....|...||:|.::.:..:|..|:.:.:...:||:.|.|..|
Worm   575 LISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLA 639

  Fly   634 GLTYGLYIGDKGLVMRVS----------------GYNEKLPLLVEIILNMMQTIELDIGQVNA-F 681
            ||...|.....|:.||||                ||:||..|..:.:.|.|...::|..:.:. |
Worm   640 GLKCQLESSPFGVQMRVSNRREAERHASLTLHVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLF 704

  Fly   682 KDLKKRQIYNALINGKSLNLDLRLSILENKRFSMISKYESVDDITMDDIKSFKENFHKKMYVKGL 746
            :.||:....:|......|.......::.:|.:|........|.:|::|::.|.:...:..:::..
Worm   705 ESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELF 769

  Fly   747 IQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDN-----HLLQIPLGSYYLRAKTLNEDDSNTI- 805
            :.||.||.:|..|.::::|..||...::.....|     ..||:..|..|:........|...:
Worm   770 VHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVE 834

  Fly   806 ITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQET 870
            :|  ||||..:.....::.|::.::.||.||.|||.|.|||.:....|:..|.:|..:.:...::
Worm   835 VT--YQIGVQNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKS 897

  Fly   871 KHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYF 935
               .|:|.:|||.|...:.:.:::|...||.|....:|...:....:|.....|.|:||..::|.
Worm   898 ---VDHVLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYN 959

  Fly   936 FNRIETQIQMLSHLTKEDVLNFLND---NDKNNLRKLSVQVVG-NHNQTSNST 984
            |.|.|.::.:|..:.|:|||...:.   .|....|||:|.|.| |.:|.:.:|
Worm   960 FARREEEVALLKTIKKDDVLELFDKKIRKDAAERRKLAVFVHGKNEDQEAVNT 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	257/999 (26%)
		Peptidase_M16	85..214	CDD:279066	43/128 (34%)
		Peptidase_M16_C	244..419	CDD:282978	42/184 (23%)
		Peptidase_M16_M	436..720	CDD:292805	72/302 (24%)
		Peptidase_M16_C	724..907	CDD:282978	48/188 (26%)
F44E7.4	NP_741543.1	Ptr	75..1039	CDD:223956	256/989 (26%)
		Peptidase_M16	95..233	CDD:279066	49/159 (31%)
		Peptidase_M16_C	259..436	CDD:282978	43/193 (22%)
		Peptidase_M16_M	444..744	CDD:292805	72/303 (24%)
		Peptidase_M16_C	747..925	CDD:282978	46/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830