DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10588 and Ide

DIOPT Version :9

Sequence 1:	NP_001287135.1	Gene:	CG10588 / 40316	FlyBaseID:	FBgn0037037	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_036017339.1	Gene:	Ide / 15925	MGIID:	96412	Length:	1044	Species:	Mus musculus

Alignment Length:	1053	Identity:	279/1053 - (26%)
Similarity:	499/1053 - (47%)	Gaps:	96/1053 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RQQYPMSTASVVVQYHEEPDKSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSST 86
            :|.|...:...:.:..::..||..|.:.||.|.|:||::.:||||...|:.|
Mouse    61 KQTYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSS------------- 112

  Fly    87 ENFNGKLAACAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTE 151
                     .|:.|.:||.|:|....||:||.|||:|:|::|:|.|||:..|:::..|.|||.|.
Mouse   113 ---------AALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTS 168

  Fly   152 NEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASL 216
            .|.|.:||::...||:..:|.|......||.......||.:||.||.|:..|.|..|..|:..:.
Mouse   169 GEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKAT 233

  Fly   217 ASEGYPHGTFSWGNYKTL-----KEGVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELEEL 276
            .:..:|...|..||..||     :||:|   :.:||.||:..:|.||.|.:.:..:.|||:|..|
Mouse   234 GNPKHPFSKFGTGNKYTLETRPNQEGID---VREELLKFHSTYYSSNLMAICVLGRESLDDLTNL 295

  Fly   277 LVRHCADIPTSQQNSIDVSQLNYQKAFRDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPD 341
            :|:..:::   :..::.:.:.. :..|:::..:.::.:.|::|:..|.:|:.:|.::.:|:|.|.
Mouse   296 VVKLFSEV---ENKNVPLPEFP-EHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPG 356

  Fly   342 MFISQLIGYEGVGSLCAYLRHHLWCISVVAGVAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLE 406
            .::..|||:||.|||.:.|:...|..::|.|..|.:..    :..|.|.:.|:::|..|:::::.
Mouse   357 HYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARG----FMFFIINVDLTEEGLLHVEDIIL 417

  Fly   407 ATFAWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYF 471
            ..|.:::.:......:..::|.:.:....|||:.:..|..:...|....:|.|...|||...|..
Mouse   418 HMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLE 482

  Fly   472 QYEESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIK 536
            ::....|:::...:...|..:.|.|. .:| .:.|:.|.|:|||:|..::|......|:.:....
Mouse   483 EFRPDLIDMVLDKLRPENVRVAIVSK-SFE-GKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNG 545

  Fly   537 ELHYPQPNPFVTTDFKIHWVE-SGKPHVSRSPKALIRND-LCELWFRQDNIFKLPDGYINLYFIT 599
            :...|..|.|:.|:|:|..:| ...|:     .|||::. :.:|||:||:.|.||...:|..|.:
Mouse   546 KFKLPTKNEFIPTNFEILSLEKDATPY-----PALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 605

  Fly   600 PLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEII 664
            ..:........:..||..|::..:.|..|.|..:||:|.:..|...:::.|.|||:|.|:|::.|
Mouse   606 RYLYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYAIASGMNAILLSVKGYNDKQPILLKKI 670

  Fly   665 LNMMQTIELDIGQVNAFKDLKKRQIYNALINGKSLNLDLRLSILENK-RFSMISKYESVDDITMD 728
            ...|.|.|:|..:....|:...|.:.|........:....|.:|..: .::.....|::||:|:.
Mouse   671 TEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLP 735

  Fly   729 DIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHL-----LQIPLG 788
            .:|:|......:::::.|:.||.|:..|..:||.|.||. .|.......|.:.|     :|:|..
Mouse   736 RLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTL-IEHAHTKPLLPSQLVRYREVQLPDR 799

  Fly   789 SYYLRAKTLNEDDSNTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQR 853
            .:::..:. ||..:|..|..|||...........::|...|:.||.||.|||:|||||.:....|
Mouse   800 GWFVYQQR-NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPR 863

  Fly   854 IGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSL 918
            ...|:......|.:::..|   |:|.|:|||...|.:.:..|::..|:...:.|...:......|
Mouse   864 RANGIQGLRFIIQSEKPPH---YLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 925

  Fly   919 DEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLNDN---DKNNLRKLSVQVVGNHNQT 980
            ..|..:.|.||::::|.::|...::..|..|||:|::.|..:.   |.....|:||.|
Mouse   926 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHV------- 983

  Fly   981 SNSTAQASRSGSLSDLLDDVQDNMANETDSAK-----PMTDKIRLEFLGESDDPSSIKDIYAFKK 1040
                                   :|.|.||..     |..:.|.|........|..|.::..||:
Mouse   984 -----------------------LAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKR 1025

  Fly  1041 DLYVFPLFNTNPN 1053
            .|.:|||...:.|
Mouse  1026 GLPLFPLVKPHIN 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	261/968 (27%)
		Peptidase_M16	85..214	CDD:279066	47/128 (37%)
		Peptidase_M16_C	244..419	CDD:282978	42/174 (24%)
		Peptidase_M16_M	436..720	CDD:292805	73/286 (26%)
		Peptidase_M16_C	724..907	CDD:282978	53/187 (28%)
Ide	XP_036017339.1	Ptr	70..983	CDD:223956	260/957 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S927
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.680