DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sems and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_649270.1	Gene:	Sems / 40315	FlyBaseID:	FBgn0037036	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	232	Identity:	71/232 - (30%)
Similarity:	110/232 - (47%)	Gaps:	23/232 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TRVIGGRVTTNAKLGGYL-VAMRYFNNFICGGTLIHELIVLTAAHCFED--RAEKEAWSVDGGIS 103
            :|::||:.....:..... ||:.:  ...|||:::....|:|||||...  .|...:|.|..|:
Human   216 SRIVGGQSVAPGRWPWQASVALGF--RHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGL- 277

  Fly   104 RLSEKGIRRQ----VKRFIKSAQFKMVTMNMDVAVVLLNRPM-VGKNIGTLSLCSTA----LTPG 159
             :|...:|..    |:|.|....:.....:.|||::.|...: ....:|  ::|..|    ...|
Human   278 -VSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG--AVCLPAKEQHFPKG 339

  Fly   160 QTMDVSGWGMTNPDDEGPGHMLRTVSVPVIEKRICREAYRESVSISDSMFCASVL-GKKDACTYD 223
            ....|||||.|:|.......||:...||:...::|..:...|.:::..|.||..| |:.|||..|
Human   340 SRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGD 404

  Fly   224 SGGPLVYEK----QVCGIVSFGIGCASRRYPGVYTDV 256
            ||||||...    ::.|:||:|.|||...:||||..|
Human   405 SGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sems	NP_649270.1	Tryp_SPc	43..263	CDD:214473	71/231 (31%)
Sems	NP_649270.1	Tryp_SPc	44..265	CDD:238113	70/230 (30%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133
		Tryp_SPc	217..448	CDD:214473	71/231 (31%)
		Tryp_SPc	218..451	CDD:238113	70/230 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910