Protein Alignment Sems and AZU1

DIOPT Version :10

• Sequence 1: NP_649270.1
• Gene: Sems / 40315
• FlyBaseID: FBgn0037036
• Length: 275
• Species: Drosophila melanogaster
• Sequence 2: NP_001691.1
• Gene: AZU1 / 566
• HGNCID: 913
• Length: 251
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 75/292 - (25%)
• Similarity: 113/292 - (38%)
• Gaps: 82/292 - (28%)

  Fly     1 MKRLLFLFLLAGILINNHALQHNETIDLKKLAKIVLPPAYQTRVIGGRVTTNAKLGGYLVAMRYF 65
            |.||..|.||||:|.::.| ..:..:|                ::||| ....:...:|.:::..
Human     1 MTRLTVLALLAGLLASSRA-GSSPLLD----------------IVGGR-KARPRQFPFLASIQNQ 47

  Fly    66 NNFICGGTLIHELIVLTAAHCFE-------------------DRAEKEAWSVDGGISRLSEKGIR 111
            ....|||.|||...|:|||.||:                   :|..::.:|    ||.:||.|..
Human    48 GRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFS----ISSMSENGYD 108

  Fly   112 RQVKRFIKSAQFKMVTMNM-DVAVVLLNRP---MVGKNIGTLSLCSTALTPGQTMDVSGWGMTNP 172
            .|              .|: |:.::.|:|.   .....|..|.|.:..:..|....|:|||
Human   109 PQ--------------QNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWG---- 155

  Fly   173 DDEGPGHML----RTVSVPVIEKRICREAYRESVSISDSMFCASVLGKKDA-CTYDSGGPLVYEK 232
             .:..|..|    |.|:|.|..:..||          .:..|..||.::.. |..|.|.|||.|.
Human   156 -SQRSGGRLSRFPRFVNVTVTPEDQCR----------PNNVCTGVLTRRGGICNGDGGTPLVCEG 209

  Fly   233 QVCGIVSFGIG-CASRRYPGVYTDVHYVKPFI 263
            ...|:.||.:| |.  |.|..:|.|...:.:|
Human   210 LAHGVASFSLGPCG--RGPDFFTRVALFRDWI 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sems	NP_649270.1	Tryp_SPc	43..263	CDD:214473	63/248 (25%)
AZU1	NP_001691.1	Tryp_SPc	27..240	CDD:238113	64/249 (26%)
		Possesses antibiotic activity. /evidence=ECO:0000269|PubMed:8506327	46..70		11/23 (48%)