DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sems and PRSS53

DIOPT Version :9

Sequence 1:	NP_649270.1	Gene:	Sems / 40315	FlyBaseID:	FBgn0037036	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	161	Identity:	52/161 - (32%)
Similarity:	74/161 - (45%)	Gaps:	22/161 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 CGGTLIHELIVLTAAHCFEDRAEKEAWSVDGGISRLSEKGIRRQVKRFIKSAQFKMVTMNMDVAV 134
            |||.|:.|..||||||||..|...|.|||..| :|..|.|:    |:.|....:.......|:|:
Human   373 CGGALVSEEAVLTAAHCFIGRQAPEEWSVGLG-TRPEEWGL----KQLILHGAYTHPEGGYDMAL 432

  Fly   135 VLLNRPM-VGKNIGTLSL--CSTALTPGQTMDVSGW--GMTNPDDEGPG-HMLRTVSVPVIEKRI 193
            :||.:|: :|.::..|.|  ....|..|:    .||  |...|   |.| ..|:||.|.::..|.
Human   433 LLLAQPVTLGASLRPLCLPYPDHHLPDGE----RGWVLGRARP---GAGISSLQTVPVTLLGPRA 490

  Fly   194 CREAYR----ESVSISDSMFCASVLGKKDAC 220
            |...:.    :...|...|.|.|.:|:..:|
Human   491 CSRLHAAPGGDGSPILPGMVCTSAVGELPSC 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sems	NP_649270.1	Tryp_SPc	43..263	CDD:214473	52/161 (32%)
Sems	NP_649270.1	Tryp_SPc	44..265	CDD:238113	52/161 (32%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113
		Tryp_SPc	43..314	CDD:214473
		Tryp_SPc	359..>512	CDD:304450	48/150 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010