DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sems and Hgf

DIOPT Version :9

Sequence 1:	NP_649270.1	Gene:	Sems / 40315	FlyBaseID:	FBgn0037036	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_001276387.1	Gene:	Hgf / 15234	MGIID:	96079	Length:	728	Species:	Mus musculus

Alignment Length:	243	Identity:	76/243 - (31%)
Similarity:	121/243 - (49%)	Gaps:	28/243 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QTRVIGGRVTTNAKLGGYLVAMRYFNNFICGGTLIHELIVLTAAHCF----EDRAEKEAWSVDGG 101
            |.||:.| :.|...: |::|:::|.|..||||:||.|..||||..||    :|..:.|||.   |
Mouse   493 QLRVVNG-IPTQTTV-GWMVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWL---G 552

  Fly   102 ISRLSEKGIRRQVKRFIKSAQFKMVTMNMDVAVVLLNRPMVGKN-IGTLSLCSTALTPGQ--TMD 163
            |..:.|:|..:: |:.:..:|........|:.::.|.||.:..| :.|:.|.|...|..:  |..
Mouse   553 IHDVHERGEEKR-KQILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCS 616

  Fly   164 VSGWGMT---NPDDEGPGHMLRTVSVPVIEKRICREAYRESVSISDSMFCASV--LGKKDACTYD 223
            :.|||.|   |.|.     :||...:.::....|.:.::..|::::|..||..  :| ...|..|
Mouse   617 IYGWGYTGLINADG-----LLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIG-SGPCEGD 675

  Fly   224 SGGPLVYE----KQVCGIVSFGIGCASRRYPGVYTDVHYVKPFIVKGI 267
            .||||:.|    :.|.|::..|.|||....||::..|.|...:|.|.|
Mouse   676 YGGPLICEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVI 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sems	NP_649270.1	Tryp_SPc	43..263	CDD:214473	72/235 (31%)
Sems	NP_649270.1	Tryp_SPc	44..265	CDD:238113	72/236 (31%)
Hgf	NP_001276387.1	PAN_APPLE	41..123	CDD:238074
		KR	127..209	CDD:214527
		KR	211..289	CDD:214527
		KR	305..385	CDD:214527
		KR	389..471	CDD:238056
		Tryp_SPc	495..719	CDD:214473	72/235 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7084
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.950