DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fng and MFNG

DIOPT Version :9

Sequence 1:	NP_524191.1	Gene:	fng / 40314	FlyBaseID:	FBgn0011591	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_002396.2	Gene:	MFNG / 4242	HGNCID:	7038	Length:	321	Species:	Homo sapiens

Alignment Length:	289	Identity:	131/289 - (45%)
Similarity:	176/289 - (60%)	Gaps:	9/289 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 DLSQRAVTATPQ-------PPVTELDDIFISVKTTKNYHDTRLALIIKTWFQLARDQTWFFTDTD 187
            :||.:.|..||:       ||..:|.|:||:||||:.:|..||.|::.||....|:||:.|||:.
Human    29 NLSPQRVQGTPELSQPNPGPPKLQLHDVFIAVKTTRAFHRLRLELLLDTWVSRTREQTFVFTDSP 93

  Fly   188 DHYYQEKTKGHLINTKCSQGHFRKALCCKMSAELDVFLESGKKWFCHFDDDNYVNVPRLVKLLDE 252
            |...||:...||:.|.||..|...||.|||:||.|.||.||.:||||.|||||||...|::||..
Human    94 DKGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDTFLASGLRWFCHVDDDNYVNPRALLQLLRA 158

  Fly   253 YSPSVDWYLGKPSISSPLEIHLDSKNTTTNKKITFWFATGGAGFCLSRALTLKMLPIAGGGKFIS 317
            :..:.|.|:|:||::.|:.......:..| :.:.|||||||||||::|.|.|||.|.|.|.:|:.
Human   159 FPLARDVYVGRPSLNRPIHASEPQPHNRT-RLVQFWFATGGAGFCINRKLALKMAPWASGSRFMD 222

  Fly   318 IGDKIRFPDDVTMGFIIEHLLKVPLTVVDNFHSHLEPMEFIRQDTFQDQVSFSYAHMKNQWNVIK 382
            ....||.|||.|||:|||..|...|.....||||||.::.:|.....:||:.||...:.:.||||
Human   223 TSALIRLPDDCTMGYIIECKLGGRLQPSPLFHSHLETLQLLRTAQLPEQVTLSYGVFEGKLNVIK 287

  Fly   383 VDG-FDMKTDPKRFYSLHCQLFPYFSFCP 410
            :.| |..:.||.||.||||.|:|...:||
Human   288 LQGPFSPEEDPSRFRSLHCLLYPDTPWCP 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fng	NP_524191.1	Fringe	145..394	CDD:190308	114/249 (46%)
MFNG	NP_002396.2	Fringe	51..300	CDD:190308	114/249 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155106
Domainoid	1	1.000	245	1.000	Domainoid score	I2181
eggNOG	1	0.900	-	-		E1_2C9I6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3011
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47481
OrthoDB	1	1.010	-	-		D356445at33208
OrthoFinder	1	1.000	-	-		FOG0002392
OrthoInspector	1	1.000	-	-		otm41898
orthoMCL	1	0.900	-	-		OOG6_104952
Panther	1	1.100	-	-	O	PTHR10811
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770