DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fng and LFNG

DIOPT Version :9

Sequence 1:	NP_524191.1	Gene:	fng / 40314	FlyBaseID:	FBgn0011591	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001035257.1	Gene:	LFNG / 3955	HGNCID:	6560	Length:	379	Species:	Homo sapiens

Alignment Length:	408	Identity:	158/408 - (38%)
Similarity:	227/408 - (55%)	Gaps:	47/408 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KRILQAMMLAVAVVYMTLLLYQSAYGYPGIQVPHSQ----VDALASEAVTTHRDQLLQDYVQSST 74
            ||..:.::||:|...:..||..:| ..|...:|..:    :.:||..|              .:.
Human     3 KRCGRRLLLALAGALLACLLVLTA-DPPPPPLPAERGRRALRSLAGPA--------------GAA 52

  Fly    75 PTQPGAGAPAASPTTVIIRKDIRSFN--FSDIEVSERPTATLLTELARRSRNGELLRDLSQRAVT 137
            |. ||.||.||:|..::  :|:.|.:  ||           |||   |..|:.......:.|...
Human    53 PA-PGLGAAAAAPGALV--RDVHSLSEYFS-----------LLT---RARRDAGPPPGAAPRPAD 100

  Fly   138 ATPQPPVTEL--DDIFISVKTTKNYHDTRLALIIKTWFQLARDQTWFFTDTDDHYYQEKTKGHLI 200
            ..|:|....|  .|:||:|||||.:|..||.|:::||....::.|:.|||.:|......| |:::
Human   101 GHPRPLAEPLAPRDVFIAVKTTKKFHRARLDLLLETWISRHKEMTFIFTDGEDEALARHT-GNVV 164

  Fly   201 NTKCSQGHFRKALCCKMSAELDVFLESGKKWFCHFDDDNYVNVPRLVKLLDEYSPSVDWYLGKPS 265
            .|.||..|.|:||.|||:.|.|.|:|||:|||||.|||||||:..|::||..|..:.|.|:||||
Human   165 ITNCSAAHSRQALSCKMAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPS 229

  Fly   266 ISSPLEIHLDSKNTTTNK--KITFWFATGGAGFCLSRALTLKMLPIAGGGKFISIGDKIRFPDDV 328
            :..|::.   .:..:.||  .:.|||||||||||:||.|.|||.|.|.||.|::..::||.|||.
Human   230 LDRPIQA---MERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMNTAERIRLPDDC 291

  Fly   329 TMGFIIEHLLKVPLTVVDNFHSHLEPMEFIRQDTFQDQVSFSYAHMKNQWNVIKVDG-FDMKTDP 392
            |:|:|:|.||.|||.....||||||.::.:......:||:.||...:|:.|.:.|.| |.::.||
Human   292 TIGYIVEALLGVPLIRSGLFHSHLENLQQVPTSELHEQVTLSYGMFENKRNAVHVKGPFSVEADP 356

  Fly   393 KRFYSLHCQLFPYFSFCP 410
            .||.|:||.|:|...:||
Human   357 SRFRSIHCHLYPDTPWCP 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fng	NP_524191.1	Fringe	145..394	CDD:190308	116/253 (46%)
LFNG	NP_001035257.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..107		4/20 (20%)
LFNG	NP_001035257.1	Fringe	110..358	CDD:190308	116/251 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155107
Domainoid	1	1.000	245	1.000	Domainoid score	I2181
eggNOG	1	0.900	-	-		E1_2C9I6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3011
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47481
OrthoDB	1	1.010	-	-		D356445at33208
OrthoFinder	1	1.000	-	-		FOG0002392
OrthoInspector	1	1.000	-	-		otm41898
orthoMCL	1	0.900	-	-		OOG6_104952
Panther	1	1.100	-	-	O	PTHR10811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4573
SonicParanoid	1	1.000	-	-		X1586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800