DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tlr8b and Fili

DIOPT Version :9

Sequence 1:	NP_001373638.1	Gene:	tlr8b / 403136	ZFINID:	ZDB-GENE-040219-12	Length:	1015	Species:	Danio rerio
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	135/590 - (22%)
Similarity:	217/590 - (36%)	Gaps:	141/590 - (23%)

- Green bases have known domain annotations that are detailed below.

Zfish   449 PPFTKAECLATGPVLDLSRNNIYHVNPPLFTGAENITCLNLSSNFIVSYFNGTEFAHFPKLKYLD 513
            |.:.|.|      :||||:|.|..:....|.....:..||||.| :||..:...|.....|..||
  Fly    93 PFYMKLE------ILDLSQNIIETLGSKNFEYQSELRTLNLSRN-LVSSLHKHAFKGLTNLLLLD 150

Zfish   514 LSHNRIYMHSDSALSELKALEVLDLSHN------QHYFEVAGVRNCLTFLEN------------L 560
            ||.|||.....:|||:|.:|..|||::|      .:.|:.......|.|..|            |
  Fly   151 LSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHL 215

Zfish   561 QFLKVLNLSWNEINMLTNKTLQS-DSLNELQFQGN---RLDIMWKKQRGYQSLFKSLSNLTYLDI 621
            ..||.|::|.|.:..:.|.:.:. ..|..|..|||   .||:         |.|:.|.:|.:||:
  Fly   216 HALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDL---------SAFEGLISLKHLDL 271

Zfish   622 SYNKLSEIPDDIFDYFPKTLRYISMSRNTLTDFAWEQLQSLPQLETLDLSKNKL--RVVPRKLSK 684
            |.|.|:.:|....... ..|.|:::..|..:........:|..|..|.||:...  |:..|....
  Fly   272 SDNNLTMVPTQQLSKL-SNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335

Zfish   685 HTRSLKVLDLSHN-QISKLRYSFLENVKSLQILNFANNKLKHLGASSFTTGSNHQLQILDLQRNP 748
            :|. |:.|.|::| |:|.:.....:...::..:...:|.|:.|.::.|..   .|||.|.|..||
  Fly   336 NTH-LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPV---DQLQKLYLGDNP 396

Zfish   749 IHCTCNLLDFILWL--------EKSDTILPRLATDVLCDLPESKRGHPMVSLDFKNACINNSIAE 805
            :.|.|:|    |||        |..|..:...|...:..|.:......:.......|..::.:|.
  Fly   397 LQCNCSL----LWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAA 457

Zfish   806 ILYILTSSVITLVMCTTIGIHVFYWDISYAYNFCMARFKSYYLKTNDCIYDAFVMYDTKDPMVAE 870
            :...:....|...:.||                   ...:|.|.|:....::.:
  Fly   458 LAAYIAEQHIVNALHTT-------------------EPSAYELATSSSNRNSGI----------- 492

Zfish   871 WVLNHLRLELEDRGRHVRPLCLEERDWTPGIPIMDNLNLSVHRSRKTIFVLTEGFV----HSGIF 931
                 ||::.:..|..:         |...:           |:|:.:..::||.:    |....
  Fly   493 -----LRMDRQQIGCDI---------WRDKV-----------RTRRKLLTMSEGEITCPAHIVTV 532

Zfish   932 KMAAFLAQQRLLEEGVDVMVLVLLEPVLRQSRILNLR--------------RCLCGHSVLEWPRN 982
            ..|....   ||...:.:.||..|..|.|:.::|:.|              |.|.||       |
  Fly   533 VCAVITC---LLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGH-------N 587

Zfish   983 PAAEG 987
            |...|
  Fly   588 PGGLG 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tlr8b	NP_001373638.1	leucine-rich repeat	36..57	CDD:275380
		leucine-rich repeat	58..78	CDD:275380
		LRR_8	64..116	CDD:404697
		leucine-rich repeat	79..105	CDD:275380
		leucine-rich repeat	106..121	CDD:275380
		LRR_8	126..190	CDD:404697
		leucine-rich repeat	127..150	CDD:275380
		leucine-rich repeat	151..179	CDD:275380
		PLN00113	180..>735	CDD:215061	84/310 (27%)
		leucine-rich repeat	180..224	CDD:275380
		leucine-rich repeat	225..266	CDD:275380
		leucine-rich repeat	267..290	CDD:275380
		leucine-rich repeat	347..373	CDD:275380
		leucine-rich repeat	374..397	CDD:275380
		leucine-rich repeat	462..483	CDD:275380	7/20 (35%)
		leucine-rich repeat	484..508	CDD:275380	8/23 (35%)
		leucine-rich repeat	509..532	CDD:275380	12/22 (55%)
		leucine-rich repeat	563..615	CDD:275380	16/55 (29%)
		leucine-rich repeat	586..607	CDD:275380	7/23 (30%)
		leucine-rich repeat	616..640	CDD:275380	7/23 (30%)
		leucine-rich repeat	641..664	CDD:275380	4/22 (18%)
		leucine-rich repeat	665..688	CDD:275380	7/24 (29%)
		leucine-rich repeat	689..712	CDD:275380	6/23 (26%)
		leucine-rich repeat	713..732	CDD:275380	3/18 (17%)
		LRRCT	747..795	CDD:214507	12/55 (22%)
		TIR	855..997	CDD:214587	26/151 (17%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	1/3 (33%)
		leucine-rich repeat	98..121	CDD:275380	8/28 (29%)
		LRR_8	120..180	CDD:404697	25/60 (42%)
		leucine-rich repeat	122..145	CDD:275380	8/23 (35%)
		leucine-rich repeat	146..169	CDD:275380	12/22 (55%)
		LRR	<161..>354	CDD:227223	54/203 (27%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	16/55 (29%)
		leucine-rich repeat	266..289	CDD:275380	7/23 (30%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	17/63 (27%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100