DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and DGCR2

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_005128.1	Gene:	DGCR2 / 9993	HGNCID:	2845	Length:	550	Species:	Homo sapiens

Alignment Length:	265	Identity:	59/265 - (22%)
Similarity:	90/265 - (33%)	Gaps:	93/265 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 CSLAEFSCSNG--RCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRV 276
            |:..:|:|.:|  :|:||...|:....|.|.|||.. |....    |::...:..|...|:|.|
Human    30 CNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEAN-CPEVT----GEVRPHHGKEAVDPRQGR- 88

  Fly   277 PFVCVLTFTAAGG--QHGDVVQVTLDSFTIGRFTSYVHEGCPDG---YMQIAESARTPIGG--MW 334
                     |.||  .|...|.|....    ||:|::.: ||.|   |...|...|..:.|  .|
Human    89 ---------ARGGDPSHFHAVNVAQPV----RFSSFLGK-CPTGWHHYEGTASCYRVYLSGENYW 139

  Fly   335 -----CGSSWGPVLFYSETRSLIFTIRLNRLA------------RDQ-----------SGYNFDF 371
                 |....|.:..:|..:.|.|.     ||            :||           :|.|...
Human   140 DAAQTCQRLNGSLATFSTDQELRFV-----LAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSL 199

  Fly   372 RIRYKVLSRDSSVT--------------------------RYGGIKLAELAQWH-----NRSSFL 405
            ..|::|..:.||..                          .:..::..:|..||     .:||||
Human   200 EGRWEVAFKGSSEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFL 264

  Fly   406 NQQQQ 410
            .::.|
Human   265 CKRSQ 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	11/32 (34%)
		CUB	503..646	CDD:238001
		LDLa	1203..1231	CDD:197566
DGCR2	NP_005128.1	LDLa	30..66	CDD:238060	13/36 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..92		6/36 (17%)
		CLECT_DGCR2_like	115..267	CDD:153069	30/156 (19%)
		VWC	271..329	CDD:214564
		Atrophin-1	<428..537	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900