DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and Lrp4

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_112612.2 Gene:Lrp4 / 83469 RGDID:619731 Length:1905 Species:Rattus norvegicus


Alignment Length:1260 Identity:228/1260 - (18%)
Similarity:379/1260 - (30%) Gaps:436/1260 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 SSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDE-------PRFC-TRCNRTYYGDIGQTYA 265
            :.|..|:..:|.|.||||:...|.||.:|||||.|||       ||.. ..||....|...:...
  Rat   307 TGSPQCASDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQM 371

  Fly   266 LELHRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAESARTPI 330
            :      :..|...|...:           ::|.|    ||....|:|...:||  .::......
  Rat   372 I------RGAVQCTCHTGY-----------RLTED----GRTCQDVNECAEEGY--CSQGCTNSE 413

  Fly   331 GGM--WCGSSW--------------GPVLFYS---ETRSLI-----FTIRLNRLARDQSGYNFDF 371
            |..  ||.:.:              .|||.::   :.|.::     :|:.||.|   ::....||
  Rat   414 GAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNL---ENAIALDF 475

  Fly   372 RIRYKVLSRDSSVTRYGGIKLAELAQWHN--RSSFLNQQQQQQQQQQQQQQQQQGAPGILED--- 431
            ..|                  .||..|.:  ....|.........::......:...|:..|   
  Rat   476 HHR------------------RELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVH 522

  Fly   432 ----FTNSSVARSDRYGQDFSLFSAYANNKTFM-ASLEKSLAKDEQNYTEPKYYLGDLIPGTYCS 491
                :|:|..:|.:....|      .|:.|..: .||||           |:......:.||.  
  Rat   523 DKLYWTDSGTSRIEVANLD------GAHRKVLLWQSLEK-----------PRAIALHPMEGTI-- 568

  Fly   492 RIFSDCDKKPCRLQSPNFPG-----------IYPRNLTCYYAVRQH---DVPH---------GKH 533
             .::|....| |:::.:..|           .:|..||..||.|:.   |..|         |.|
  Rat   569 -YWTDWGNTP-RIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSH 631

  Fly   534 ALILVKQP----------KGNLVWIS--TQETAAANKMAPPPSASDKDKKFEPRLKTWNYCDYIQ 586
            ...::.|.          :.:|.|..  |:...:|||.........::|...|            
  Rat   632 RKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFP------------ 684

  Fly   587 ENVKPKWKSTDYVTVYDGYTTRDPIILKFCG------------GGQAVPAAVSSGPELL------ 633
                        :.::..:..|.|.....||            .||....|..:|...:      
  Rat   685 ------------MDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKINSHACA 737

  Fly   634 -----------------VEFSTSPFGTFTGTSSQVLPLYGFQLEV---------EVQFVDIQSPT 672
                             :.|.|...      |..|:||...:..|         .|.:.|:.:.|
  Rat   738 QSLDKFLLFARRMDIRRISFDTEDL------SDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDT 796

  Fly   673 YSKNKKPCEFWIRGAGRGI-----LESPKHSLAPNSTCLYHLQGLGVFKTFDHLSLSRRTSSQSG 732
            .|:.|     | .|.|:.:     ||||........|...:....|.    |.:.::....|   
  Rat   797 ISRAK-----W-DGTGQKVVVDTSLESPAGLAIDWVTNKLYWTDAGT----DRIEVANTDGS--- 848

  Fly   733 MHQPLSRFKVWISVLKFNLD--------PEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDA 789
                :....:|     .|||        |..|.:..|..||...::.    :||    |.:.|..
  Rat   849 ----MRTVLIW-----ENLDRPRDIVVEPMGGYMYWTDWGASPKIER----AGM----DASNRQV 896

  Fly   790 PVCKDLNCATETS-SYNTLGHYTHNSTSVIARFC--RGTIPRTCDRSNINETYARPCTISESYVS 851
            .:..:|......: .|.:...|..::......|.  .|:..:....|.:...:.  .|:....:.
  Rat   897 IISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFG--LTLYGQRIY 959

  Fly   852 TSDAITLELRNTESTVLRPLDFKLKYE----FIDLH-----------QDGLPWGGGEHDCNRKFL 901
            .:|..|..:::.:.  |..||.:...|    .:|:|           ...:..||..|.|.|.  
  Rat   960 WTDWQTKSIQSADR--LTGLDRETLQENLENLMDIHVFHRQRPPVTTPCAVENGGCSHLCLRS-- 1020

  Fly   902 SSMMDRKDPAIFRSV----RNIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRV 962
                  ..|:.|...    .|:.|.|:..:..:.....|    ..|:.::|   .:.:.|.::.|
  Rat  1021 ------PSPSGFSCTCPTGINLLLDGKTCSPGMNSFLIF----ARRIDVRM---VSLDIPYFADV 1072

  Fly   963 DEDINRSFCYGDTNVRIEIFE-RPYHDSILLHRGCMCNSSNQSH-------------LPVEY--- 1010
            ...||.:. .....:.::..| :.|.....|||....:.....|             |.|:.   
  Rat  1073 VVPINMTM-KNTIAIGVDPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGR 1136

  Fly  1011 ------TSTSRDVEVHFIAQNM------TTLDDPDTVNFEGMFEFV---------KAPTSCKDG- 1053
                  |.|:| :||..:..:|      ..||.|..:.......|:         |...|..|| 
  Rat  1137 KVYWTDTGTNR-IEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS 1200

  Fly  1054 ------RRKFG-PSG-TIDMT---------------FGDVECRSRPWLIEPSNGNKFLYVRLKAI 1095
                  ....| |:| |:|.|               ..|:...:|..|:.|              
  Rat  1201 DRTVLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSP-------------- 1251

  Fly  1096 FLSKHNPTQTLNATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERP 1160
              .:|....||..:|:....|:..:..||..:|...:.:|.      ||....::|         
  Rat  1252 --VQHPYGLTLLDSYIYWTDWQTRSIHRADKSTGSNVILVR------SNLPGLMDI--------- 1299

  Fly  1161 NFALVNRSRAISVEFLRPGNGEYSFNWMELIPRPTLSMAEDCQFKCAELGACVNASVWCDGVVHC 1225
              ..|:|::.:........||..|.   ..:|||:       .|.||                 |
  Rat  1300 --QAVDRAQPLGFNKCGSRNGGCSH---LCLPRPS-------GFSCA-----------------C 1335

  Fly  1226 PSG------------DDETFLQCSA 1238
            |:|            ..||:|..|:
  Rat  1336 PTGIQLKGDGKTCDPSPETYLLFSS 1360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 16/30 (53%)
CUB 503..646 CDD:238001 31/212 (15%)
LDLa 1203..1231 CDD:197566 6/39 (15%)
Lrp4NP_112612.2 LDLa 27..66 CDD:238060
Ldl_recept_a 70..105 CDD:278486
LDLa 110..142 CDD:238060
LDLa 148..182 CDD:238060
LDLa 231..265 CDD:238060
LDLa 270..304 CDD:238060
LDLa 311..343 CDD:197566 16/31 (52%)
FXa_inhibition 358..393 CDD:291342 9/55 (16%)
EGF_CA 395..434 CDD:214542 7/40 (18%)
NHL <471..622 CDD:302697 34/189 (18%)
NHL repeat 471..507 CDD:271320 7/53 (13%)
LDL-receptor class B 1 480..522 6/41 (15%)
LY 505..545 CDD:214531 7/45 (16%)
NHL repeat 510..550 CDD:271320 8/45 (18%)
LDL-receptor class B 2 523..565 11/58 (19%)
NHL repeat 555..589 CDD:271320 8/48 (17%)
LDL-receptor class B 3 566..609 10/46 (22%)
LY 590..632 CDD:214531 9/41 (22%)
NHL repeat 598..622 CDD:271320 8/23 (35%)
LDL-receptor class B 4 610..652 6/41 (15%)
LY 633..673 CDD:214531 7/39 (18%)
LDL-receptor class B 5 653..693 8/63 (13%)
FXa_inhibition 702..>729 CDD:291342 6/26 (23%)
LY 766..806 CDD:214531 11/45 (24%)
LDL-receptor class B 6 785..827 12/47 (26%)
LY 808..850 CDD:214531 8/52 (15%)
LDL-receptor class B 7 828..870 8/57 (14%)
LDL-receptor class B 8 871..914 10/50 (20%)
Ldl_recept_b 871..911 CDD:278487 9/47 (19%)
LY 895..937 CDD:214531 5/41 (12%)
LDL-receptor class B 9 915..956 5/42 (12%)
LY 938..979 CDD:214531 6/44 (14%)
LDL-receptor class B 10 957..998 8/42 (19%)
FXa_inhibition 1006..1043 CDD:291342 10/44 (23%)
NHL <1085..1277 CDD:302697 37/208 (18%)
NHL repeat 1085..1123 CDD:271320 6/37 (16%)
LDL-receptor class B 11 1093..1135 7/41 (17%)
NHL repeat 1128..1161 CDD:271320 8/33 (24%)
LDL-receptor class B 12 1136..1178 9/42 (21%)
NHL repeat 1166..1203 CDD:271320 8/36 (22%)
LDL-receptor class B 13 1179..1222 10/42 (24%)
NHL repeat 1212..1244 CDD:271320 6/31 (19%)
LDL-receptor class B 14 1223..1263 7/55 (13%)
NHL repeat 1253..1277 CDD:271320 5/23 (22%)
LDL-receptor class B 15 1264..1306 11/58 (19%)
FXa_inhibition 1313..1348 CDD:291342 12/61 (20%)
LY 1379..1418 CDD:214531
LDL-receptor class B 16 1397..1439
LY 1420..1460 CDD:214531
LDL-receptor class B 17 1440..1482
LDL-receptor class B 18 1483..1526
Ldl_recept_b 1483..1523 CDD:278487
LY 1507..1547 CDD:214531
LDL-receptor class B 19 1527..1568
LY 1549..1589 CDD:214531
LDL-receptor class B 20 1569..1610
FXa_inhibition 1617..>1641 CDD:291342
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1853..1905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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