DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and Cubn

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_445784.3	Gene:	Cubn / 80848	RGDID:	68355	Length:	3623	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	229/1212 - (18%)
Similarity:	341/1212 - (28%)	Gaps:	481/1212 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 TQCRAIKATE-TPATSKMTSSCSGHCQSQQQQ------------QQQQHQLQQQHQQSQHQQRRH 138
            |....|..|| ....|...|.||.|.|....|            |...::.|..::...:.....
  Rat   250 TPPNGISCTEDKDECSLQPSPCSEHAQCFNTQGSFYCGACPKGWQGNGYECQDINECEINNGGCS 314

  Fly   139 PLPATLTLLLCLGISLGMAATAAAAGGGGGGGGGAAPV---SGSGAAGFPSSSSSISSSLG---- 196
            ..|    |:.||. :.|..:......|..|.|....||   |.......|.::.|.|..||
  Rat   315 QAP----LVPCLN-TPGSFSCGNCPAGFSGDGRVCTPVDICSIHNGGCHPEATCSSSPVLGSFLP 374

  Fly   197 -----PGKPVNLQLAPGSSSTGC-----SLAEFSCSNGRCVPL--SKYC------------NNLN 237
                 ||...|     |..|.||     ..:...|.||:|:..  |.:|            .|:|
  Rat   375 VCTCPPGYTGN-----GYGSNGCVRLSNICSRHPCVNGQCIETVSSYFCKCDSGWSGQNCTENIN 434

  Fly   238 DCGDGSDEPRF---------------CTRCNRTYY--------GDI--GQTYALELHRPKQDRVP 277
            ||   |..|..               ||.....||        |.|  |.......|.|....:.
  Rat   435 DC---SSNPCLNGGTCIDGINGFTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYHSPNDTYIH 496

  Fly   278 FV-CVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAE---SARTPIGGMWCGSS 338
            .| |   |.........|:.||...|.:...::     ||..|:||.:   ||..|: |.:|||.
  Rat   497 NVNC---FWIVRTDEEKVLHVTFTFFDLESASN-----CPREYLQIHDGDSSADFPL-GRYCGSR 552

  Fly   339 WGPVLFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSS 403
             .|...:|...:|.|.:....:   :||..|                         .|:|
  Rat   553 -PPQGIHSSANALYFHLYSEYI---RSGRGF-------------------------TARW----- 583

  Fly   404 FLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMASLEKSLA 468
                           :.:.....|||          :|.||.
  Rat   584 ---------------EAKLPECGGIL----------TDNYGS----------------------- 600

  Fly   469 KDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSPNFPGIYPRNLTCYYAVRQHDVPHGKH 533
                                               :.||.:||.||....|.:.|..:  |:.
  Rat   601 -----------------------------------ITSPGYPGNYPPGRDCVWQVLVN--PNS-- 626

  Fly   534 ALILVKQPKGNLVWISTQETAAANKMAPPPSASDKDKKFEPRLKTWNYCDYIQENVKPKWKSTDY 598
               |:....|.|                             .|::.|.|            |.||
  Rat   627 ---LITFTFGTL-----------------------------SLESHNDC------------SKDY 647

  Fly   599 VTVYDGYTTRDPIILKFCGGGQAVPAAVSSGPELLVEF------STSPF--------------GT 643
            :.:.||...:||::.||| ...:.|...::||...:.|      |...|              |.
  Rat   648 LEIRDGPFHQDPVLGKFC-TSLSTPPLKTTGPAARIHFHSDSETSDKGFHITYLTTQSDLDCGGN 711

  Fly   644 FTGTSSQVL--PLYGFQLEVEVQFVDIQSPTYSKNKKPCEFWIRGA-GRGILESPKH-SLAPNST 704
            :|.|..::|  ||.|               .:|.::: |.:.|..| |..|:.:..| .|.....
  Rat   712 YTDTDGELLLPPLSG---------------PFSHSRQ-CVYLITQAQGEQIVINFTHVELESQMG 760

  Fly   705 CLYHLQGLGVFKTFDHLSLSRRTSSQSGMHQPLSRF--KVWISVLKFNLDPEFGQIDETSVGAIG 767
            |.:....:|     ||.||.|:......:. |:...  ||||.:          :||.....|..
  Rat   761 CSHTYIEVG-----DHDSLLRKICGNETLF-PIRSVSNKVWIRL----------RIDALVQKASF 809

  Fly   768 VLQTQEDCSGMLRIWDGTLR-------------------------------DAPVCKDLNCATET 801
            ....|..|.|||| .:|..|                               |..:....:|.|:
  Rat   810 RADYQVACGGMLR-GEGFFRSPFYPNAYPGRRTCRWTISQPQRQVVLLNFTDFQIGSSASCDTD- 872

  Fly   802 SSYNTLGHYTHNSTSVIA-----RFCRGTIPRTCDRSNINETYARPCTISESYVSTSDAITLELR 861
              |..:|     .:||:.     :||...||     |.|...|      :..||:...:.::|.|
  Rat   873 --YIEIG-----PSSVLGSPGNEKFCSSNIP-----SFITSVY------NILYVTFVKSSSMENR 919

  Fly   862 NTESTVLRPLDFKLKYEFIDLHQDGLPWGGGEHDCNRKFLSSMMDRKDPAIFRSVRNIFLFGRGG 926
            .          |..|:.     .|.|       :|.....:|      ..|..|..:..::.||
  Rat   920 G----------FTAKFS-----SDKL-------ECGEVLTAS------TGIIESPGHPNVYPRG- 955

  Fly   927 TRNLKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRVDEDINRSFCYGDTNVRIEIFERPYHDSIL 991
               :.|.:....|||:.:|::.               ......|.|..||..:||::......:
  Rat   956 ---VNCTWHVVVQRGQLIRLEF---------------SSFYLEFHYNCTNDYLEIYDTAAQTFL- 1001

  Fly   992 LHRGCMCNSSNQSHLPVEYTSTSRDVEVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSC-KDGRR 1055
               |..|..|    :|...||.|..:::.|::.:....:     .|...:|.:.|.:.| .|...
  Rat  1002 ---GRYCGKS----IPPSLTSNSNSIKLIFVSDSALAHE-----GFSINYEAIDASSVCLYDYTD 1054

  Fly  1056 KFGPSGTIDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCET 1120
            .||                  .|..|:..|.:                         ...|.|..
  Rat  1055 NFG------------------MLSSPNFPNNY-------------------------PSNWECIY 1076

  Fly  1121 KSRAVLTTSEGLTIVACPLSP--DSNAYEFVEIFSSGWNERP 1160
            :....|.....|......|..  .|...:||||...|:...|
  Rat  1077 RITVGLNQQIALHFTDFILEDYFGSQCVDFVEIRDGGYETSP 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	12/49 (24%)
		CUB	503..646	CDD:238001	32/162 (20%)
		LDLa	1203..1231	CDD:197566
Cubn	NP_445784.3	cubilin_NTD	38..132	CDD:412063
		Interaction with AMN. /evidence=ECO:0000250\|UniProtKB:O60494	39..46
		EGF_CA	133..164	CDD:238011
		EGF_CA	167..207	CDD:238011
		EGF_CA	260..301	CDD:214542	8/40 (20%)
		EGF_CA	302..345	CDD:214542	8/47 (17%)
		EGF_3	350..387	CDD:403986	9/41 (22%)
		EGF_CA	400..430	CDD:238011	6/29 (21%)
		EGF_CA	432..468	CDD:238011	10/38 (26%)
		CUB	474..585	CDD:238001	33/168 (20%)
		CUB	590..699	CDD:238001	37/225 (16%)
		CUB	708..815	CDD:238001	30/138 (22%)
		CUB	817..927	CDD:238001	27/144 (19%)
		CUB	932..1041	CDD:238001	26/146 (18%)
		CUB	1048..1157	CDD:395345	19/114 (17%)
		CUB	1165..1275	CDD:238001
		CUB	1278..1388	CDD:238001
		CUB	1391..1505	CDD:238001
		CUB	1510..1617	CDD:238001
		CUB	1620..1733	CDD:238001
		CUB	1738..1847	CDD:238001
		CUB	1852..1962	CDD:238001
		CUB	1978..2088	CDD:238001
		CUB	2092..2212	CDD:238001
		CUB	2217..2333	CDD:238001
		CUB	2336..2447	CDD:238001
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3623	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47537
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010