DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and Cubn

DIOPT Version :10

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_445784.3 Gene:Cubn / 80848 RGDID:68355 Length:3623 Species:Rattus norvegicus


Alignment Length:1212 Identity:229/1212 - (18%)
Similarity:341/1212 - (28%) Gaps:481/1212 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 TQCRAIKATE-TPATSKMTSSCSGHCQSQQQQ------------QQQQHQLQQQHQQSQHQQRRH 138
            |....|..|| ....|...|.||.|.|....|            |...::.|..::...:.....
  Rat   250 TPPNGISCTEDKDECSLQPSPCSEHAQCFNTQGSFYCGACPKGWQGNGYECQDINECEINNGGCS 314

  Fly   139 PLPATLTLLLCLGISLGMAATAAAAGGGGGGGGGAAPV---SGSGAAGFPSSSSSISSSLG---- 196
            ..|    |:.||. :.|..:......|..|.|....||   |.......|.::.|.|..||    
  Rat   315 QAP----LVPCLN-TPGSFSCGNCPAGFSGDGRVCTPVDICSIHNGGCHPEATCSSSPVLGSFLP 374

  Fly   197 -----PGKPVNLQLAPGSSSTGC-----SLAEFSCSNGRCVPL--SKYC------------NNLN 237
                 ||...|     |..|.||     ..:...|.||:|:..  |.:|            .|:|
  Rat   375 VCTCPPGYTGN-----GYGSNGCVRLSNICSRHPCVNGQCIETVSSYFCKCDSGWSGQNCTENIN 434

  Fly   238 DCGDGSDEPRF---------------CTRCNRTYY--------GDI--GQTYALELHRPKQDRVP 277
            ||   |..|..               ||.....||        |.|  |.......|.|....:.
  Rat   435 DC---SSNPCLNGGTCIDGINGFTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYHSPNDTYIH 496

  Fly   278 FV-CVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAE---SARTPIGGMWCGSS 338
            .| |   |.........|:.||...|.:...::     ||..|:||.:   ||..|: |.:|||.
  Rat   497 NVNC---FWIVRTDEEKVLHVTFTFFDLESASN-----CPREYLQIHDGDSSADFPL-GRYCGSR 552

  Fly   339 WGPVLFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSS 403
             .|...:|...:|.|.:....:   :||..|                         .|:|     
  Rat   553 -PPQGIHSSANALYFHLYSEYI---RSGRGF-------------------------TARW----- 583

  Fly   404 FLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMASLEKSLA 468
                           :.:.....|||          :|.||.                       
  Rat   584 ---------------EAKLPECGGIL----------TDNYGS----------------------- 600

  Fly   469 KDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSPNFPGIYPRNLTCYYAVRQHDVPHGKH 533
                                               :.||.:||.||....|.:.|..:  |:.  
  Rat   601 -----------------------------------ITSPGYPGNYPPGRDCVWQVLVN--PNS-- 626

  Fly   534 ALILVKQPKGNLVWISTQETAAANKMAPPPSASDKDKKFEPRLKTWNYCDYIQENVKPKWKSTDY 598
               |:....|.|                             .|::.|.|            |.||
  Rat   627 ---LITFTFGTL-----------------------------SLESHNDC------------SKDY 647

  Fly   599 VTVYDGYTTRDPIILKFCGGGQAVPAAVSSGPELLVEF------STSPF--------------GT 643
            :.:.||...:||::.||| ...:.|...::||...:.|      |...|              |.
  Rat   648 LEIRDGPFHQDPVLGKFC-TSLSTPPLKTTGPAARIHFHSDSETSDKGFHITYLTTQSDLDCGGN 711

  Fly   644 FTGTSSQVL--PLYGFQLEVEVQFVDIQSPTYSKNKKPCEFWIRGA-GRGILESPKH-SLAPNST 704
            :|.|..::|  ||.|               .:|.::: |.:.|..| |..|:.:..| .|.....
  Rat   712 YTDTDGELLLPPLSG---------------PFSHSRQ-CVYLITQAQGEQIVINFTHVELESQMG 760

  Fly   705 CLYHLQGLGVFKTFDHLSLSRRTSSQSGMHQPLSRF--KVWISVLKFNLDPEFGQIDETSVGAIG 767
            |.:....:|     ||.||.|:......:. |:...  ||||.:          :||.....|..
  Rat   761 CSHTYIEVG-----DHDSLLRKICGNETLF-PIRSVSNKVWIRL----------RIDALVQKASF 809

  Fly   768 VLQTQEDCSGMLRIWDGTLR-------------------------------DAPVCKDLNCATET 801
            ....|..|.|||| .:|..|                               |..:....:|.|: 
  Rat   810 RADYQVACGGMLR-GEGFFRSPFYPNAYPGRRTCRWTISQPQRQVVLLNFTDFQIGSSASCDTD- 872

  Fly   802 SSYNTLGHYTHNSTSVIA-----RFCRGTIPRTCDRSNINETYARPCTISESYVSTSDAITLELR 861
              |..:|     .:||:.     :||...||     |.|...|      :..||:...:.::|.|
  Rat   873 --YIEIG-----PSSVLGSPGNEKFCSSNIP-----SFITSVY------NILYVTFVKSSSMENR 919

  Fly   862 NTESTVLRPLDFKLKYEFIDLHQDGLPWGGGEHDCNRKFLSSMMDRKDPAIFRSVRNIFLFGRGG 926
            .          |..|:.     .|.|       :|.....:|      ..|..|..:..::.|| 
  Rat   920 G----------FTAKFS-----SDKL-------ECGEVLTAS------TGIIESPGHPNVYPRG- 955

  Fly   927 TRNLKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRVDEDINRSFCYGDTNVRIEIFERPYHDSIL 991
               :.|.:....|||:.:|::.               ......|.|..||..:||::......: 
  Rat   956 ---VNCTWHVVVQRGQLIRLEF---------------SSFYLEFHYNCTNDYLEIYDTAAQTFL- 1001

  Fly   992 LHRGCMCNSSNQSHLPVEYTSTSRDVEVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSC-KDGRR 1055
               |..|..|    :|...||.|..:::.|::.:....:     .|...:|.:.|.:.| .|...
  Rat  1002 ---GRYCGKS----IPPSLTSNSNSIKLIFVSDSALAHE-----GFSINYEAIDASSVCLYDYTD 1054

  Fly  1056 KFGPSGTIDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCET 1120
            .||                  .|..|:..|.:                         ...|.|..
  Rat  1055 NFG------------------MLSSPNFPNNY-------------------------PSNWECIY 1076

  Fly  1121 KSRAVLTTSEGLTIVACPLSP--DSNAYEFVEIFSSGWNERP 1160
            :....|.....|......|..  .|...:||||...|:...|
  Rat  1077 RITVGLNQQIALHFTDFILEDYFGSQCVDFVEIRDGGYETSP 1118

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 12/49 (24%)
CUB 503..646 CDD:238001 32/162 (20%)
LDLa 1203..1231 CDD:197566
CubnNP_445784.3 cubilin_NTD 38..132 CDD:412063
Interaction with AMN. /evidence=ECO:0000250|UniProtKB:O60494 39..46
EGF_CA 133..164 CDD:238011
EGF_CA 167..207 CDD:238011
EGF_CA 260..301 CDD:214542 8/40 (20%)
EGF_3 306..344 CDD:463759 8/42 (19%)
EGF_3 350..387 CDD:463759 9/41 (22%)
EGF_CA 400..430 CDD:238011 6/29 (21%)
EGF_CA 432..468 CDD:238011 10/38 (26%)
CUB 474..585 CDD:238001 33/168 (20%)
CUB 590..699 CDD:238001 37/225 (16%)
CUB 708..815 CDD:238001 30/138 (22%)
CUB 817..927 CDD:238001 27/144 (19%)
CUB 932..1041 CDD:238001 26/146 (18%)
CUB 1048..1157 CDD:395345 19/114 (17%)
CUB 1165..1275 CDD:238001
CUB 1278..1388 CDD:238001
CUB 1391..1505 CDD:238001
CUB 1510..1617 CDD:238001
CUB 1620..1733 CDD:238001
CUB 1738..1847 CDD:238001
CUB 1852..1962 CDD:238001
CUB 1978..2088 CDD:238001
CUB 2092..2212 CDD:238001
CUB 2217..2333 CDD:238001
CUB 2336..2447 CDD:238001
CUB 2452..2564 CDD:238001
CUB 2570..2686 CDD:238001
CUB 2689..2800 CDD:238001
CUB 2805..2918 CDD:238001
CUB 2920..3034 CDD:238001
CUB 3037..3148 CDD:238001
CUB 3157..3273 CDD:238001
CUB 3278..3392 CDD:238001
CUB 3395..3506 CDD:238001
CUB 3511..3623 CDD:238001
Blue background indicates that the domain is not in the aligned region.

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