DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and CUBN

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_001072.2 Gene:CUBN / 8029 HGNCID:2548 Length:3623 Species:Homo sapiens


Alignment Length:1310 Identity:236/1310 - (18%)
Similarity:375/1310 - (28%) Gaps:532/1310 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 GAAPVSGSGAAGFPSSSSSISSSLGPGKPVNLQLAPG-------SSSTGCSLAEFSCSN----GR 225
            |:.|..|. .|.:.||..::.....|..|.....:||       |.:..|   |::.||    ..
Human  2551 GSRPYGGF-TASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNC---EWTLSNPNQGNS 2611

  Fly   226 CVPL---SKYCNNLNDC---------GDGSDEP---RFCTRCNRTY-----YGDIGQTYALELHR 270
            .:.:   ..|..:..||         || :|.|   |.|.....|.     |..:.      :|.
Human  2612 SISIHFEDFYLESHQDCQFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVW------IHF 2669

  Fly   271 PKQDRVP---FVCVLTFTAAGG-QHGDVVQVTLDSFTIGRFTSYVHEGC------PDGY------ 319
            ...:||.   |....:||..|| |.||...:|..::. ..:.|..|  |      |.|:      
Human  2670 VTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYP-NAYDSLTH--CSSLLEAPQGHTITLTF 2731

  Fly   320 -----------------MQIAESARTPIGGMWCGSSWGPVLFYSETRSLIFTIRLNRLARDQSGY 367
                             ::...|..:||.|.:||:| .|....|.:..|:.|            :
Human  2732 SDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNS-NPRTIQSGSNQLVVT------------F 2783

  Fly   368 NFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDF 432
            |.|..::             ||   ...|.|:.                    |..|..||..  
Human  2784 NSDHSLQ-------------GG---GFYATWNT--------------------QTLGCGGIFH-- 2810

  Fly   433 TNSSVARSDRYGQDF----------------SLFSAYANNKTFM-----ASLEKSLAKDEQNYTE 476
            :::...||..:.|:|                .|..::.||  |:     ...:.|..|......|
Human  2811 SDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNN--FLIPSGDGQCQNSFVKVWAGTEE 2873

  Fly   477 PKYYL-----GDLIPG-------------------------TYCSRIFSDCDKKPCRLQSPNFPG 511
            ....|     |::.||                         ::.||..|:.......:.|||:|.
Human  2874 VDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPK 2938

  Fly   512 IYPRNLTCYYAVRQHD-----------------------VPHGKHALILVKQPKGNLVWISTQET 553
            .|..|:.|.|.:..:.                       |..|.|.:      :|..|..:...|
Human  2939 QYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHII------RGYSVMSTPFAT 2997

  Fly   554 AAANKMAPP--------------PSASDKDKKFEPRL----------------KTWNYCDYIQE- 587
            ...::|..|              ...:|...||..|:                ..::|.||..: 
Human  2998 VCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPNDM 3062

  Fly   588 ---------------------NVKPKWK-STDYVTVYDGYTTRDPIILKFCGGGQAVPAAVSSGP 630
                                 :|.|... |.||:.:|||..|.||::.||| |.:..|...||..
Human  3063 HCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFC-GSKRPPNVKSSNN 3126

  Fly   631 ELLVEFSTSPFGTFTGTSSQVLPLYGFQLEVEVQFVDIQSPTYSKNKKPCEFWIRGAGRGILESP 695
            .:|:.|.|..|.|                                            .:|...|.
Human  3127 SMLLVFKTDSFQT--------------------------------------------AKGWKMSF 3147

  Fly   696 KHSLAPNSTCLYHLQGLGVFKTFDHLSLSRRTSSQSGMHQPLSRFKVWISV--------LKFNLD 752
            :.:|.|.       ||.|.:.|..:.:.:...|..:||:.. :...|||.:        |.||  
Human  3148 RQTLGPQ-------QGCGGYLTGSNNTFASPDSDSNGMYDK-NLNCVWIIIAPVNKVIHLTFN-- 3202

  Fly   753 PEFGQIDETSVGAIGVLQTQEDC-SGMLRIWDGTLRDAPVCKDLNCATETSSYNTLGHYTHNSTS 816
                      ..|:....|::.| ...::::||...:|                          :
Human  3203 ----------TFALEAASTRQRCLYDYVKLYDGDSENA--------------------------N 3231

  Fly   817 VIARFCRGTIPRTCDRSNINETYARPCTISESYVSTSDAITLELRNTESTVLRPLDFKLKYEFID 881
            :...||..|:|                   ..::|:.:.:|::.  .....|....|...|..:|
Human  3232 LAGTFCGSTVP-------------------APFISSGNFLTVQF--ISDLTLEREGFNATYTIMD 3275

  Fly   882 LHQDGLPWGGGEHDCNRKFLSSMMDRKDPAIFRSVRNIFLFGRGGTRNLKCIYKFEAQRGERVRI 946
                 :|.||..:........|..:..||.:..|:               |.:..::...::|:|
Human  3276 -----MPCGGTYNATWTPQNISSPNSSDPDVPFSI---------------CTWVIDSPPHQQVKI 3320

  Fly   947 KMRKVTTTNRPC---YSRVDEDINRSFCYGDTNVRIEIFERPYHDSILLHRGCMCNSSNQSHLPV 1008
            .:..:..|::.|   |.::.:...     |..|.|.:...|                 |.|.:||
Human  3321 TVWALQLTSQDCTQNYLQLQDSPQ-----GHGNSRFQFCGR-----------------NASAVPV 3363

  Fly  1009 EYTSTSRDVEVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSC-KDGRRKFG-------------- 1058
            .|:|.|..:.:.          ....||......|......| :|..:.||              
Human  3364 FYSSMSTAMVIF----------KSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDND 3418

  Fly  1059 ----------PSGTIDMTF------GDVECRSRPWLIEPSNGNKFLYVR----LKAIFLSKHNPT 1103
                      .:.||.:.|      ..||||           |.||.||    ..:..|.|:..|
Human  3419 KDCTVTLTAPQNHTISLFFHSLGIENSVECR-----------NDFLEVRNGSNSNSPLLGKYCGT 3472

  Fly  1104 QTLNATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERPN--FALVN 1166
            ...|..:.|.:......||.:| |:..|              ||.:      |...|:  ...:.
Human  3473 LLPNPVFSQNNELYLRFKSDSV-TSDRG--------------YEII------WTSSPSGCGGTLY 3516

  Fly  1167 RSRAISVEFLRPG-NGEYSFN----WMELIPRPTLSMAEDCQFKCAELGACV----------NAS 1216
            ..|.   .|..|| .|.|..|    |:.:.|...|...........:.|.||          |||
Human  3517 GDRG---SFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNAS 3578

  Fly  1217 -----VWCDG 1221
                 .:|.|
Human  3579 SPSSGPYCGG 3588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 9/46 (20%)
CUB 503..646 CDD:238001 46/218 (21%)
LDLa 1203..1231 CDD:197566 8/34 (24%)
CUBNNP_001072.2 Interaction with AMN. /evidence=ECO:0000269|PubMed:30523278 42..49
EGF_CA 136..167 CDD:238011
EGF_CA 170..210 CDD:238011
EGF_CA 263..304 CDD:214542
EGF_3 309..347 CDD:289699
EGF_3 353..387 CDD:289699
EGF_CA 399..430 CDD:238011
EGF_CA 432..468 CDD:238011
CUB 474..585 CDD:238001
CUB 590..699 CDD:238001
CUB 708..815 CDD:238001
CUB 817..927 CDD:238001
CUB 932..1041 CDD:238001
CUB 1048..1157 CDD:294042
CUB 1165..1275 CDD:238001
CUB 1282..1388 CDD:238001
CUB 1391..1505 CDD:238001
CUB 1510..1617 CDD:238001
CUB 1620..1733 CDD:238001
CUB 1738..1847 CDD:238001
CUB 1859..1962 CDD:238001
CUB 1978..2088 CDD:278839
CUB 2092..2212 CDD:238001
CUB 2217..2333 CDD:238001
CUB 2336..2447 CDD:238001
CUB 2452..2564 CDD:238001 4/13 (31%)
CUB 2570..2686 CDD:238001 24/125 (19%)
CUB 2689..2800 CDD:238001 28/142 (20%)
CUB 2805..2918 CDD:238001 17/116 (15%)
CUB 2920..3034 CDD:238001 20/119 (17%)
CUB 3037..3148 CDD:238001 28/155 (18%)
CUB 3157..3273 CDD:238001 26/175 (15%)
CUB 3278..3392 CDD:238001 26/160 (16%)
CUB 3395..3506 CDD:238001 29/142 (20%)
CUB 3511..3621 CDD:238001 18/81 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR47537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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