DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and LRP8

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:XP_005271230.1 Gene:LRP8 / 7804 HGNCID:6700 Length:976 Species:Homo sapiens


Alignment Length:649 Identity:125/649 - (19%)
Similarity:198/649 - (30%) Gaps:229/649 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 GGGGGGGAAPV-----------------------SGSGAAGFPSSSSSISS-SLGPGKPVNL--- 203
            ||.|||...|.                       .|.||...|::.::.|. :...|:.|:|   
Human   214 GGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278

  Fly   204 -----QLAPGSSSTGCSLA-----EFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYG 258
                 .....|....|.|.     ||.|.:|.||...|:||...||.|||||.. |.:...|:.|
Human   279 CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG-CLQVPPTFLG 342

  Fly   259 DIGQTYALE--LHRP-------KQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIG--------- 305
            :..:...|.  ||..       ...::.|.|.   ..||.|       .||..|.|         
Human   343 NRRRPRGLNECLHNNGGCSHICTDLKIGFECT---CPAGFQ-------LLDQKTCGDIDECKDPD 397

  Fly   306 -------RFTSYVHEGCPDGYMQ--IAESARTPIGGMWCGSSWGPVLFYSETRSLIFTIR--LNR 359
                   .:..|....|..||..  :.::.:...|               ::.|||||.|  :.|
Human   398 ACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAG---------------KSPSLIFTNRHEVRR 447

  Fly   360 LARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQG 424
            :...:..|:....:...|::.|..|.. ..|...:|:.....|:::::....::|:....:|...
Human   448 IDLVKRNYSRLIPMLKNVVALDVEVAT-NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHS 511

  Fly   425 APGILEDFTNS------------SVARSDRYGQDFSLFSAYANN---------KTFM-------- 460
            ..|:..|:.:.            |||..|. |:..:|||...:.         :.||        
Human   512 PEGLAVDWVHKHIYWTDSGNKTISVATVDG-GRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQ 575

  Fly   461 ASLEKS---------LAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSPNFPG----- 511
            |.:|||         |..|  |...|.....||:    ..|::. .|.|..:|.|.:|.|     
Human   576 AKIEKSGLNGVDRQTLVSD--NIEWPNGITLDLL----SQRLYW-VDSKLHQLSSIDFSGGNRKT 633

  Fly   512 ------------------------------IY-------------------PRNLTCYYAVRQHD 527
                                          |:                   |.::..::.::|  
Human   634 LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQ-- 696

  Fly   528 VPHGKHALILVKQPKGNLVWISTQETAAANKMAPPPSASDKDKKFE----------PRLK----- 577
             |....|..|..||.|...::          ..|.|..|....|:.          |.:|     
Human   697 -PRAPDACELSVQPNGGCEYL----------CLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRA 750

  Fly   578 -----TWNYCDYIQENVKPKWK---STDYVTVYDGYTTRDPIILKFCGGGQAVPAAVSSGPELL 633
                 |......:...|....:   :|.:.:.|..::|..|.:........:||.|.|..|..|
Human   751 PQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 16/35 (46%)
CUB 503..646 CDD:238001 31/208 (15%)
LDLa 1203..1231 CDD:197566
LRP8XP_005271230.1 LDLa 47..81 CDD:238060
LDLa 85..117 CDD:197566
LDLa 127..163 CDD:238060
LDLa 206..240 CDD:197566 6/25 (24%)
Ldl_recept_a 262..294 CDD:278486 5/31 (16%)
Ldl_recept_a 298..333 CDD:278486 16/35 (46%)
FXa_inhibition 353..387 CDD:291342 9/43 (21%)
EGF_CA 389..419 CDD:214542 3/29 (10%)
LY 458..493 CDD:214531 6/35 (17%)
LY 502..544 CDD:214531 8/42 (19%)
Ldl_recept_b 565..605 CDD:278487 10/41 (24%)
LY 589..631 CDD:214531 13/48 (27%)
Ldl_recept_b 652..691 CDD:278487 2/38 (5%)
FXa_inhibition 710..747 CDD:291342 7/46 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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