DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and VLDLR

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens


Alignment Length:619 Identity:118/619 - (19%)
Similarity:198/619 - (31%) Gaps:202/619 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 VSGSGAAGFPSSSSSISSSLGPGKPVNLQLAPGSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCG 240
            |.||...    :..:::..|||||                   |.|.:|.|:.:||.||...||.
Human   304 VDGSDEV----NCKNVNQCLGPGK-------------------FKCRSGECIDISKVCNQEQDCR 345

  Fly   241 DGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIG 305
            |.||||......|.....:.|.:     |..|...:.:.|   ..|||.:       .:|..|.|
Human   346 DWSDEPLKECHINECLVNNGGCS-----HICKDLVIGYEC---DCAAGFE-------LIDRKTCG 395

  Fly   306 RFTSYVHEG----------------CPDGY-MQIAESARTPIGGMWCGSSWGPVLFYSETRSLIF 353
            ......:.|                |..|| |.:|......:|               :..||||
Human   396 DIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVG---------------KEPSLIF 445

  Fly   354 TIR--LNRLARDQSGY-NFDFRIRYKV-LSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQQQQQ 414
            |.|  :.::..::..| ....::|..| |..|.:..:   :..|:|:|   ::.|......:..:
Human   446 TNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQK---LFWADLSQ---KAIFSASIDDKVGR 504

  Fly   415 QQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMASLEKSLAKDEQNYTEPKY 479
            ..:..........|..|:...::..:|...:..|:.:.....:.|:.:         .:..||..
Human   505 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN---------SDLREPAS 560

  Fly   480 YLGDLIPG-TYCSRIFSDCDKKPCRLQSPNFPGI-----------YPRNLTC------------- 519
            ...|.:.| .|    :||.. :|.:::.....|.           :|..:|.             
Human   561 IAVDPLSGFVY----WSDWG-EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSK 620

  Fly   520 YYAVRQHDVPHGKHALILVK------QP------KGNLVWISTQETA--AANKMAPPPSAS---- 566
            .:.:...|: :|:...|::|      .|      :..:.||..:..|  .|||......|:    
Human   621 LHMLSSVDL-NGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNN 684

  Fly   567 ---DKD-----KKFEPRLKTW-------NYCDYI-----QEN-VKPKW----------------- 593
               .:|     :..:|..|.|       ..|:|:     |.| ..||:                 
Human   685 LNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749

  Fly   594 KSTDYVTVY----DGYTTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTFTGTSSQVLPL 654
            :||.....|    |..||..........||..|..|||       |.|..|.|  |..:..:|||
Human   750 QSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVS-------EVSVPPKG--TSAAWAILPL 805

  Fly   655 Y--------GFQL-----EVEVQFVDIQSPTYSK 675
            .        |:.:     ...::.::..:|.|.|
Human   806 LLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 12/30 (40%)
CUB 503..646 CDD:238001 41/226 (18%)
LDLa 1203..1231 CDD:197566
VLDLRNP_003374.3 LDLa 33..67 CDD:238060
LDLa 71..103 CDD:197566
Ldl_recept_a 111..149 CDD:278486
LDLa 154..188 CDD:238060
Ldl_recept_a 192..224 CDD:278486
Ldl_recept_a 237..273 CDD:278486
Ldl_recept_a 276..312 CDD:278486 3/11 (27%)
Ldl_recept_a 320..350 CDD:278486 16/48 (33%)
FXa_inhibition 360..394 CDD:291342 8/48 (17%)
EGF_CA 396..426 CDD:214542 3/29 (10%)
Ldl_recept_b 481..521 CDD:278487 5/45 (11%)
LY 505..547 CDD:214531 4/41 (10%)
Ldl_recept_b 568..608 CDD:278487 8/44 (18%)
LY 592..634 CDD:214531 4/42 (10%)
Ldl_recept_b 655..694 CDD:278487 8/38 (21%)
FXa_inhibition 706..749 CDD:291342 6/42 (14%)
Mucin <751..813 CDD:250634 20/70 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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