DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32432 and SORL1

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_003096.2	Gene:	SORL1 / 6653	HGNCID:	11185	Length:	2214	Species:	Homo sapiens

Alignment Length:	1259	Identity:	237/1259 - (18%)
Similarity:	385/1259 - (30%)	Gaps:	472/1259 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 FSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPFVCVLT 283
            |.|.||.|:|.||:|:.|.||.|||||......|  |::.|                  |||...
Human  1242 FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLC--THFMD------------------FVCKNR 1286

  Fly   284 FTAAGGQHGDVVQVTLDSFTIGRFTSYVHEG---CPDGYMQIAESARTPIGGMWCGSSWGPVLFY 345
                        |..|       |.|.|.:|   |.||..:.|..|         |.|..|
Human  1287 ------------QQCL-------FHSMVCDGIIQCRDGSDEDAAFA---------GCSQDP---- 1319

  Fly   346 SETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQ 410
                      ..:::. |:.|:
Human  1320 ----------EFHKVC-DEFGF------------------------------------------- 1330

  Fly   411 QQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQ--DFSLFSAYANNKTFMASLEKSLAKDEQN 473
                     |.|.|.       ..|.:.:.|....  |:|                     ||.|
Human  1331 ---------QCQNGV-------CISLIWKCDGMDDCGDYS---------------------DEAN 1358

  Fly   474 YTEP-------KYYL-----GDLIPGTY-CSRIFSDC----DKKPCRLQSPNFPGIYPRNLTC-- 519
            ...|       :|:.     |..||..: |.| .:||    |:|.|. .|...|...|...||
Human  1359 CENPTEAPNCSRYFQFRCENGHCIPNRWKCDR-ENDCGDWSDEKDCG-DSHILPFSTPGPSTCLP 1421

  Fly   520 -YYAVRQHDVPHGKHALILVKQPKGNLV---WI----------STQETA--AAN-KMAPPPSASD 567
             ||                 :...|..|   |:          |.:|..  .|| ..|..|:...
Human  1422 NYY-----------------RCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLG 1469

  Fly   568 KDKKFE-----PR--LKTWNYCDYIQENVKPKWKSTDYVTVYDG--------YTTRDPIILKF-C 616
            :..:||     |:  :..|..||..|:             ..||        ::|...:..:| |
Human  1470 RCDRFEFECHQPKTCIPNWKRCDGHQD-------------CQDGRDEANCPTHSTLTCMSREFQC 1521

  Fly   617 GGGQAVPAAVSSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQ-LEVEVQFVDIQSPTYSKNKKPC 680
            ..|:|. ..:|...:..::.|..   :.....|..|.:|..| |:....|....:.|:.:.||
Human  1522 EDGEAC-IVLSERCDGFLDCSDE---SDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKK-- 1580

  Fly   681 EFWIRGAGRGILESPKHSLAPNSTCLYHLQ----GLGVFKTFDHLSLSRRTSSQSGMHQPLSRFK 741
                               .|:::|:|::.    |..::||.:  :.|.:|::...:.:|.:.::
Human  1581 -------------------MPSASCVYNVYYRVVGESIWKTLE--THSNKTNTVLKVLKPDTTYQ 1624

  Fly   742 VWISV---LKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDAPVCKDLNCATETSS 803
            |.:.|   .|.:...:|           ..|:|.|.           |.|||....|:...|...
Human  1625 VKVQVQCLSKAHNTNDF-----------VTLRTPEG-----------LPDAPRNLQLSLPREAEG 1667

  Fly   804 YNTLGH-----YTHN-STSVIARFCR-GTIPRTCDRSNINETYARPCTISESYVSTSDAIT---- 857
            . .:||     :||. ....|..:.| |:......|:..|.|..:...::..|.....|:|
Human  1668 V-IVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGI 1731

  Fly   858 ------LELRNTESTVLRP------------LDFKLKYEFIDLHQDG----LPWGGGEHDCNRKF 900
                  ..:...:..|:.|            |.|.|..| .|:..:|    |.|....|...|:.
Human  1732 GNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTME-SDIKVNGYVVNLFWAFDTHKQERRT 1795

  Fly   901 LSSMMDRKDPAIFRSVRNIFLFGRGGTRNLKCIYKFEA-----------------QRGER---VR 945
            |             :.|...|..:.|.......|:..|                 .||.|   ..
Human  1796 L-------------NFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPS 1847

  Fly   946 IKMRKVTTTNRPCYSRVDEDINRSFCYGDTNVRIEIFERPYHDSILLHRGCMCNSSNQSHL---- 1006
            :|.:.:..|...|......::.....|..:  .::::..|...:..||...:..|.::.:|
Human  1848 LKAKAINQTAVECTWTGPRNVVYGIFYATS--FLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVR 1910

  Fly  1007 -PVEYTSTSRDVEV--------------HFIAQNMTTL--------DDPDTVNFEGMFEFVKAPT 1048
             .|.|...|.|..|              |.:....|::        |.||        :.:....
Human  1911 VVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPD--------QDLLYAV 1967

  Fly  1049 SCKDGRRKFGPS-------GTIDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTL 1106
            :.||..||...|       .|::.|...         :||  |.|: ::.::...:||.:..:..
Human  1968 AVKDLIRKTDRSYKVKSRNSTVEYTLNK---------LEP--GGKY-HIIVQLGNMSKDSSIKIT 2020

  Fly  1107 NATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGW-------NERPNFAL 1164
            ..:....|..:..|::..||...:.|.:.....: :|..|| :.:|.|..       |...||
Human  2021 TVSLSAPDALKIITENDHVLLFWKSLALKEKHFN-ESRGYE-IHMFDSAMNITAYLGNTTDNF-- 2081

  Fly  1165 VNRSRAISVEFLRPGNGEYSFNWM-------ELIPRPTLSMAEDCQFKCAELGACVNASVWCDGV 1222
                  ..:..|:.|: .|:|...       ::...|.:.:.:       |||
Human  2082 ------FKISNLKMGH-NYTFTVQARCLFGNQICGEPAILLYD-------ELG------------ 2120

  Fly  1223 VHCPSGDDETFLQCSALMKLPAEILATLCLIFVLSCCAFAAFAYKKIKRKLRGS------SVLQT 1281
                ||.|.:..|.:....:.|.::..|.|| :||.....|..|.| .|:|:.|      |...:
Human  2121 ----SGADASATQAARSTDVAAVVVPILFLI-LLSLGVGFAILYTK-HRRLQSSFTAFANSHYSS 2179

  Fly  1282 RLKS--LSSMDTAVLDEKEKKPVV 1303
            ||.|  .||.|....|: |..|::
Human  2180 RLGSAIFSSGDDLGEDD-EDAPMI 2202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	15/25 (60%)
		CUB	503..646	CDD:238001	32/177 (18%)
		LDLa	1203..1231	CDD:197566	5/27 (19%)
SORL1	NP_003096.2	Cell attachment site. /evidence=ECO:0000255	63..65
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531
		LDL-receptor class B 3	888..932
		Ldl_recept_b	890..929	CDD:278487
		LY	913..953	CDD:214531
		LDL-receptor class B 4	933..970
		LDL-receptor class B 5	971..1013
		LDLa	1078..1112	CDD:238060
		LDLa	1120..1153	CDD:238060
		Ldl_recept_a	1157..1192	CDD:278486
		LDLa	1198..1230	CDD:197566
		LDLa	1240..1271	CDD:238060	17/28 (61%)
		LDLa	1281..1308	CDD:197566	12/45 (27%)
		LDLa	1325..1359	CDD:238060	11/114 (10%)
		LDLa	1373..1403	CDD:238060	9/30 (30%)
		LDLa	1419..1453	CDD:238060	8/50 (16%)
		LDLa	1471..1506	CDD:238060	9/47 (19%)
		LDLa	1513..1546	CDD:197566	6/36 (17%)
		FN3	1557..>1628	CDD:238020	16/93 (17%)
		FN3	1651..1742	CDD:238020	18/91 (20%)
		FN3	1749..1829	CDD:214495	17/93 (18%)
		FN3	1934..2021	CDD:238020	18/106 (17%)
		FN3	2025..2112	CDD:238020	17/97 (18%)
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305\|PubMed:16531402	2161..2164		1/3 (33%)
		Endocytosis signal. /evidence=ECO:0000255	2172..2177		1/4 (25%)
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269\|PubMed:17646382	2190..2214		4/14 (29%)
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269\|PubMed:11821067	2201..2214		0/2 (0%)
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269\|PubMed:20015111	2208..2212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900